2023
Mechanisms of liver fibrosis in metabolic syndrome
Mehal W. Mechanisms of liver fibrosis in metabolic syndrome. EGastroenterology 2023, 1: e100015. PMID: 37946713, PMCID: PMC10634657, DOI: 10.1136/egastro-2023-100015.Peer-Reviewed Original ResearchNon-alcoholic steatohepatitisLiver fibrosisMetabolic syndromeHepatic stellate cellsHepatocellular injuryImmune systemHSC transdifferentiationGrowth factorChronic hepatocellular injuryInnate immune cellsMetabolite changesInnate immune systemAdaptive immune systemNASH fibrosisHepatocellular damageAntifibrotic strategiesImmune cellsProfibrotic roleT cellsFree fatty acidsStellate cellsViral infectionFibrosisSyndromeEndothelial cells
2019
Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9
Vijay G, Hu C, Peng J, Garcia-Martinez I, Hoque R, Verghis RM, Ma Y, Mehal W, Shawcross DL, Wen L. Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9. Cellular And Molecular Gastroenterology And Hepatology 2019, 8: 609-623. PMID: 31401214, PMCID: PMC6889059, DOI: 10.1016/j.jcmgh.2019.08.002.Peer-Reviewed Original ResearchConceptsAcute liver failureT cell cytokine productionBrain edemaCell cytokine productionCytokine productionT cell expressionBrain waterIntracranial hypertensionTotal plasma DNAFl/AC injectionAcetaminophen-induced acute liver failureAmmonia-induced brain edemaCell expressionToll-like receptor 9Intracellular cytokine productionLymphocyte cytokine productionMacrophage cytokine productionSystemic inflammationImmune dysfunctionLiver failureTLR9 expressionWT miceReceptor 9T cells
2018
Role of sterile inflammation in fatty liver diseases
Chen Y, Yousaf M, Mehal W. Role of sterile inflammation in fatty liver diseases. Liver Research 2018, 2: 21-29. DOI: 10.1016/j.livres.2018.02.003.Peer-Reviewed Original ResearchNon-alcoholic steatohepatitisSterile inflammationInflammatory responseTissue damageRegulatory T cellsFatty liver diseaseAnti-inflammatory effectsHepatic inflammatory responseAcute phase reactantsHigh-fat dietPropagation of inflammationSinusoidal endothelial cellsPro-inflammatory damageTrans retinoic acidGrowth factor βLiver inflammationMetabolic syndromeLiver diseaseIL-1βInflammatory cytokinesFat dietAlcohol excessFemale micePhase reactantsT cells
2014
Food Reactivity on the ALCAT Leukocyte Activation Test Is Associated with Upregulation of CD11b on T Cells
Ghani A, Mehal W, Ali A. Food Reactivity on the ALCAT Leukocyte Activation Test Is Associated with Upregulation of CD11b on T Cells. Journal Of Alternative And Complementary Medicine 2014, 20: a35-a36. DOI: 10.1089/acm.2014.5089.abstract.Peer-Reviewed Original Research
2001
Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis
Mehal W, Azzaroli F, Crispe I. Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis. The Journal Of Immunology 2001, 167: 667-673. PMID: 11441069, DOI: 10.4049/jimmunol.167.2.667.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationApoptosisBone Marrow CellsBone Marrow TransplantationCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity, ImmunologicLiverLymphocyte ActivationLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMice, TransgenicRadiation ChimeraSpleenStem Cell TransplantationStem CellsConceptsMarrow-derived cellsNon-bone marrow-derived cellsT cellsT cell apoptosisAg presentationLiver injuryBone marrow-derived cellsCell apoptosisSuch liver injuryT cell trappingT cell accumulationBone marrow chimerasTCR transgenic miceT cell populationsT cell deletionAdoptive transferIntrahepatic accumulationLiver damageHepatocyte damageSystemic activationAntigen presentationBone marrowCell accumulationClonal expansionCell deletionInvolvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells
Dao T, Exley M, Mehal W, Tahir S, Snapper S, Taniguchi M, Balk S, Crispe I. Involvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells. The Journal Of Immunology 2001, 166: 3090-3097. PMID: 11207260, DOI: 10.4049/jimmunol.166.5.3090.Peer-Reviewed Original ResearchConceptsNK T cellsPeripheral T cell deletionT cell deletionT cellsCell deletionCD1-deficient miceBone marrow chimerasExpression of CD1T cell activationMHC-like moleculesNonlymphoid organsLymph nodesPeripheral deletionNormal miceT lymphocytesCell activationMutant mouse linesMouse linesAttenuated accumulationMiceLymphocytesNovel roleCD1Ab resultsLiver
2000
The liver as a site of T‐cell apoptosis: graveyard, or killing field?
Crispe I, Dao T, Klugewitz K, Mehal W, Metz D. The liver as a site of T‐cell apoptosis: graveyard, or killing field? Immunological Reviews 2000, 174: 47-62. PMID: 10807506, DOI: 10.1034/j.1600-0528.2002.017412.x.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntigensApoptosisCD8-Positive T-LymphocytesCell AdhesionEndothelium, VascularFas ReceptorHepatitis CHumansImmune ToleranceImmunophenotypingIntestinal AbsorptionKiller Cells, NaturalKupffer CellsLiverLiver CirculationLiver TransplantationLymphocyte ActivationLymphocyte SubsetsMiceMice, TransgenicModels, ImmunologicalPortal VeinConceptsT cellsNatural killerT cell trappingNK T cellsPeripheral immune responsePortal vein infusionApoptotic T cellsT cell apoptosisNormal mouse liverPhenomenon of toleranceApoptotic CD8Liver allograftsOral toleranceHepatitis C.Lymphocyte populationsAntigenic cellsImmune responseLiver pathogensVein infusionClearance phaseLiver resultsLiverDirect perfusionMouse liverCell populations
1999
Selective retention of activated CD8+ T cells by the normal liver.
Mehal W, Juedes A, Crispe I. Selective retention of activated CD8+ T cells by the normal liver. The Journal Of Immunology 1999, 163: 3202-10. PMID: 10477588, DOI: 10.4049/jimmunol.163.6.3202.Peer-Reviewed Original Research
1998
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells.
Dao T, Mehal W, Crispe I. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. The Journal Of Immunology 1998, 161: 2217-22. PMID: 9725214, DOI: 10.4049/jimmunol.161.5.2217.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsCytokinesCytotoxicity, ImmunologicHumansInterferon InducersInterferon-gammaInterleukin-18Jurkat CellsKiller Cells, NaturalLiverLymphoproliferative DisordersMembrane GlycoproteinsMiceMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutPerforinPore Forming Cytotoxic ProteinsT-Lymphocyte SubsetsT-Lymphocytes, CytotoxicTumor Necrosis Factor-alphaConceptsNK T cellsLiver NK T cellsIL-18NK cellsIntrahepatic lymphocyte subpopulationsNK cell activityPerforin-dependent cytotoxicityPerforin-dependent pathwayTNF-alpha productionSoluble TNF-alphaT cell linesLymphocyte subpopulationsCytotoxic cellsTNF-alphaT cellsCell activityExact mechanismNKCell populationsCell linesLiverCytotoxicityCellsCytokinesCTLTCR ligation on CD8+ T cells creates double-negative cells in vivo.
Mehal W, Crispe I. TCR ligation on CD8+ T cells creates double-negative cells in vivo. The Journal Of Immunology 1998, 161: 1686-93. PMID: 9712032, DOI: 10.4049/jimmunol.161.4.1686.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingCD8-Positive T-LymphocytesClonal DeletionFas ReceptorHistocompatibility Antigens Class IImmunophenotypingInjections, IntraperitonealLiverLymph NodesLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte Subsets
1996
Strange brew: T cells in the liver
Crispe I, Mehal W. Strange brew: T cells in the liver. Trends In Immunology 1996, 17: 522-525. PMID: 8961629, DOI: 10.1016/s0167-5699(96)80906-6.Peer-Reviewed Original Research