2023
Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers
Hawken S, Ducharme R, Murphy M, Olibris B, Bota A, Wilson L, Cheng W, Little J, Potter B, Denize K, Lamoureux M, Henderson M, Rittenhouse K, Price J, Mwape H, Vwalika B, Musonda P, Pervin J, Chowdhury A, Rahman A, Chakraborty P, Stringer J, Wilson K. Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers. PLOS ONE 2023, 18: e0281074. PMID: 36877673, PMCID: PMC9987787, DOI: 10.1371/journal.pone.0281074.Peer-Reviewed Original ResearchConceptsGestational ageCord blood dataClinical dataBlood dataMetabolomic markersEarly pregnancy ultrasoundHeel-prick blood sampleProspective birth cohortMultivariable linear regressionBlood sample dataExternal validationGestational age estimationRetrospective cohortPregnancy ultrasoundHeel prickExternal cohortIndependent cohortBlood samplesBirth cohortNewbornsPostnatal gestational age estimationCohortUltrasound estimatesInternal model validationLow-income countries
2020
External validation of ELASTIC NET regression models including newborn metabolomic markers for postnatal gestational age estimation in East and South-East Asian infants
Hawken S, Murphy M, Ducharme R, Bota A, Wilson L, Cheng W, Tumulak M, Alcausin M, Reyes M, Qiu W, Potter B, Little J, Walker M, Zhang L, Padilla C, Chakraborty P, Wilson K. External validation of ELASTIC NET regression models including newborn metabolomic markers for postnatal gestational age estimation in East and South-East Asian infants. Gates Open Research 2020, 4: 164. DOI: 10.12688/gatesopenres.13131.1.Peer-Reviewed Original ResearchCohort of infantsBirth weightMetabolomic markersLow-resource settingsResource settingsGrowth-restricted infantsNewborn metabolic profilesHeel-prick blood sampleRetrospective database studyNewborn screening programsGestational age estimationAsian infantsScreening programChinese cohortClinical utilityDatabase studyBlood samplesInfantsPostnatal gestational age estimationCohortUltrasound valuesMetabolic profileInternal validationMetabolomics modelBirth estimates