2021
Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis
Goetzl EJ, Srihari VH, Guloksuz S, Ferrara M, Tek C, Heninger GR. Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis. The FASEB Journal 2021, 35: e21339. PMID: 33454965, DOI: 10.1096/fj.202002519r.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesFunctional proteinsMitochondrial functional proteinsMitochondrial protein mitofusin 2Extracellular vesiclesMitochondrial ATP synthaseMitochondrial ATP synthase activityATP synthase activityTranscription factor AMitochondrial proteinsATP synthaseMyosin VICyclophilin DConversion of NADHMitofusin 2EV contentExosome markersPeptide humaninProteinMitochondrial impairmentSynthase activityProtein levelsFactor AMitochondriaVesicles
2020
Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis
Goetzl EJ, Srihari VH, Guloksuz S, Ferrara M, Tek C, Heninger GR. Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis. Translational Psychiatry 2020, 10: 361. PMID: 33106473, PMCID: PMC7588411, DOI: 10.1038/s41398-020-01046-3.Peer-Reviewed Original Research