1991
Long-term follow-up of ProMACE-CytaBOM in non-Hodgkin's lymphomas
Fisher R, Longo D, DeVita V, Hubbard S, Miller T, Young R. Long-term follow-up of ProMACE-CytaBOM in non-Hodgkin's lymphomas. Annals Of Oncology 1991, 2: 33-35. PMID: 1710487, DOI: 10.1093/annonc/2.suppl_1.33.Peer-Reviewed Original ResearchConceptsDisease-free survivalProMACE-MOPPCR rateComplete remissionProMACE-CytaBOMHodgkin's lymphomaLong-term disease-free survivalLong-term disease-free survivorsSurvival curvesStage IIDisease-free survival curvesFirst-generation regimensThird-generation regimensPhase II studyDisease-free survivorsOverall survival curvesSouthwest Oncology GroupCooperative group settingHigh-grade NHLNational Cancer InstituteSame time pointsVs 53Aggressive NHLII studyOncology Group
1986
Twenty years of MOPP therapy for Hodgkin's disease.
Longo D, Young R, Wesley M, Hubbard S, Duffey P, Jaffe E, DeVita V. Twenty years of MOPP therapy for Hodgkin's disease. Journal Of Clinical Oncology 1986, 4: 1295-306. PMID: 3528400, DOI: 10.1200/jco.1986.4.9.1295.Peer-Reviewed Original ResearchConceptsEnd of treatmentHodgkin's diseaseComplete responseDisease patientsLymphocyte-depleted typeHodgkin's disease patientsHigher CR rateResults of treatmentMOPP therapyB symptomsIntercurrent illnessComplete remissionLonger remissionsCR rateHodgkin's lymphomaLonger survivalBiopsy specimensPatientsHigh dosesDiseaseRemissionLymphomaMore cyclesTreatmentLarge cells
1985
Renal involvement in diffuse aggressive lymphomas: results of treatment with combination chemotherapy.
Geffen D, Fisher R, Longo D, Young R, DeVita V. Renal involvement in diffuse aggressive lymphomas: results of treatment with combination chemotherapy. Journal Of Clinical Oncology 1985, 3: 646-53. PMID: 3998781, DOI: 10.1200/jco.1985.3.5.646.Peer-Reviewed Original ResearchConceptsNormal renal functionSerum creatinine levelsRenal involvementDiffuse aggressive lymphomasRenal functionCombination chemotherapyCreatinine levelsAggressive lymphomaElevated serum creatinine levelInitial local controlRecurrent renal diseaseEvidence of diseaseSite of recurrenceResults of treatmentComplete remissionDisseminated diseaseRenal diseaseSystemic diseaseHodgkin's lymphomaComplete resolutionRadiographic criteriaPatientsLocal controlLymphomaChemotherapyProMACE-MOPP combination chemotherapy for diffuse lymphomas.
Fisher R, Young R, Longo D, DeVita V. ProMACE-MOPP combination chemotherapy for diffuse lymphomas. Seminars In Oncology 1985, 12: 29-32. PMID: 2579441.Peer-Reviewed Original ResearchConceptsComplete remissionCombination chemotherapyAdvanced stageComplete response rateLong-term survivalMOPP combination chemotherapyC-MOPPComplete respondersNew regimenHodgkin's lymphomaBurkitt's lymphomaDiffuse lymphomaResponse rateFatal diseaseLymphomaPatientsDeath rateNCI studyHigh gradeRemissionChemotherapyDiseaseLarge cellsMyelosuppressionRegimenTreatment of diffuse large cell non-Hodgkin’s lymphomas
Fisher R, Devita V, Longo D, Ihde D, Young R. Treatment of diffuse large cell non-Hodgkin’s lymphomas. Developments In Oncology 1985, 465-469. DOI: 10.1007/978-1-4613-2607-6_49.Peer-Reviewed Original ResearchLong-term disease-free survivalDisease-free survivalAdvanced stageAdvanced diffuse histiocytic lymphomaDiffuse mixed lymphomaDiffuse histiocytic lymphomaDiffuse large cellDiffuse aggressive lymphomasLarge cell lymphomaComplete remissionComplete respondersCombination chemotherapyMixed lymphomaAggressive lymphomaHodgkin's lymphomaHistiocytic lymphomaTherapeutic resultsCell lymphomaBurkitt's lymphomaLymphomaFatal diseaseTreatment programPatientsSurvivalLarge cells
1984
Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience.
Tester W, Kinsella T, Waller B, Makuch R, Kelley P, Glatstein E, DeVita V. Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience. Journal Of Clinical Oncology 1984, 2: 762-9. PMID: 6547479, DOI: 10.1200/jco.1984.2.7.762.Peer-Reviewed Original ResearchConceptsSecond malignant neoplasmsHodgkin's diseaseMalignant neoplasmsSolid tumorsNational Cancer Institute ExperienceChronic myeloid leukemiaCases of sarcomaRisk of leukemiaUntreated patientsPatient ageHodgkin's lymphomaMedical recordsInstitute experienceMyeloid leukemiaSimilar riskAge 40Treatment groupsPatientsGreater riskLeukemiaTen yearsDiseaseTumorsLymphomaPositive association
1982
Undifferentiated non‐Hodgkin'S lymphomas (Burkitt's and non‐Burkitt's types). The relevance of making this histologic distinction
Miliauskas J, Berard C, Young R, Garvin A, Edwards B, Devita V. Undifferentiated non‐Hodgkin'S lymphomas (Burkitt's and non‐Burkitt's types). The relevance of making this histologic distinction. Cancer 1982, 50: 2115-2121. PMID: 7127252, DOI: 10.1002/1097-0142(19821115)50:10<2115::aid-cncr2820501024>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsBurkitt's lymphomaMedian ageStage IVPrimary siteHistologic distinctionIntra-abdominal involvementFive-year survivalNational Cancer InstituteMedian survivalBurkitt's typeRetrospective studyHodgkin's lymphomaPatient populationLonger survivalCancer InstituteLymphomaPatientsSurvivalDiseaseMonthsAgePresentationYearsCases
1980
Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations
Come S, Jaffe E, Andersen J, Mann R, Johnson B, DeVita V, Young R. Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations. The American Journal Of Medicine 1980, 69: 667-674. PMID: 7001897, DOI: 10.1016/0002-9343(80)90416-7.Peer-Reviewed Original ResearchConceptsPeripheral blood involvementBlood involvementHistologic subtypeLeukemic phaseAdult lymphoblastic lymphomaDiffuse large cell lymphomaNon-Hodgkin lymphomaLarge cell lymphomaHomogeneous clinical pictureTypes of NHLLymphoblastic lymphomaRappaport classificationClinical pictureClinicopathologic entityHodgkin's lymphomaNodular lymphomaUnresponsive diseaseClinicopathologic correlationLymphocytic lymphomaClinical subtypesLeukemic conversionCell lymphomaCytologic featuresHigh riskPredominant cells
1979
A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non‐Hodgkin's lymphoma
Brereton H, Young R, Longo D, Kirkland L, Berard C, Jaffe E, Devita V, Johnson R. A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non‐Hodgkin's lymphoma. Cancer 1979, 43: 2227-2231. PMID: 378350, DOI: 10.1002/1097-0142(197906)43:6<2227::aid-cncr2820430611>3.0.co;2-j.Peer-Reviewed Original ResearchCentral nervous system complications of non-Hodgkin's lymphoma The potential role for prophylactic therapy
Young R, Howser D, Anderson T, Fisher R, Jaffe E, DeVita V. Central nervous system complications of non-Hodgkin's lymphoma The potential role for prophylactic therapy. The American Journal Of Medicine 1979, 66: 435-443. PMID: 433950, DOI: 10.1016/0002-9343(79)91065-9.Peer-Reviewed Original ResearchConceptsCentral nervous systemCNS diseaseHodgkin's lymphomaCentral nervous system complicationsNervous system complicationsWhole-brain irradiationGood clinical responseBone marrow involvementTime of diagnosisGroup of patientsAdvanced diseaseBrain irradiationClinical remissionCNS prophylaxisIntrathecal chemotherapyLymphomatous meningitisProphylactic therapyClinical responseMarrow involvementPositive cytologyMalignant lymphomaSystem complicationsLumbar punctureNodular lymphomaRisk factorsCNS Infiltration: A Complication of Diffuse Lymphomas
Young R, Howser D, Anderson T, Jaffe E, DeVita V. CNS Infiltration: A Complication of Diffuse Lymphomas. 1979, 121-130. DOI: 10.1007/978-1-349-04285-2_11.Peer-Reviewed Original ResearchCentral nervous systemHistological patternVaried histological patternsHigh-risk populationDiffuse histological patternVaried natural historyCNS complicationsCNS recurrenceNeurological complicationsProphylactic therapySerious complicationsLymphomatous involvementRappaport classificationHodgkin's lymphomaSuccessful therapyHigh riskDistinct histologyNervous systemDiffuse lymphomaComplications
1978
Sequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma
Chabner B, Johnson R, Young R, Canellos G, Hubbard S, Johnson S, Devita V. Sequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma. Cancer 1978, 42: 922-925. PMID: 150938, DOI: 10.1002/1097-0142(197808)42:2+<922::aid-cncr2820420714>3.0.co;2-9.Peer-Reviewed Original Research
1977
Peritoneoscopy: a technique to evaluate therapeutic efficacy in non-Hodgkin's lymphoma patients.
Anderson T, Bender R, Rosenoff S, Brereton H, Chabner B, DeVita V, Hubbard S, Young R. Peritoneoscopy: a technique to evaluate therapeutic efficacy in non-Hodgkin's lymphoma patients. Journal Of The National Cancer Institute 1977, 61: 1017-22. PMID: 143345.Peer-Reviewed Original ResearchConceptsHodgkin's lymphoma patientsPercutaneous liver biopsyLymphoma patientsHepatic involvementLiver biopsyComplete clinical remissionLow morbidity rateActive diseaseClinical relapseClinical remissionIntensive chemotherapyPersistent diseaseLess morbidityMorbidity rateHodgkin's lymphomaPatientsTherapeutic efficacyBiopsyRelapseLymphomaDiseaseInvolvementLaparotomyRemissionMorbidity
1976
Pathological staging of 100 consecutive untreated patients with non‐Hodgkin's lymphomas. Extramedullary sites of disease
Lotz M, Chabner B, Devita V, Johnson R, Berard C. Pathological staging of 100 consecutive untreated patients with non‐Hodgkin's lymphomas. Extramedullary sites of disease. Cancer 1976, 37: 266-270. PMID: 1247961, DOI: 10.1002/1097-0142(197601)37:1<266::aid-cncr2820370136>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsPathological stagingHodgkin's lymphomaNodular lymphomaHepatic biopsyDiffuse lymphomaFirst positive biopsyPercutaneous hepatic biopsyConsecutive untreated patientsBone marrow needle biopsyNegative spleensAbdominal involvementExploratory laparotomyUntreated patientsHepatic involvementWedge biopsyHistologic typeOverall incidenceRappaport classificationAbdominal diseasePositive biopsiesExtramedullary sitesNeedle biopsyUntreated casesPatientsBiopsy
1975
Results of combination chemotherapy of non-Hodgkin's lymphoma.
Schein P, Chabner B, Canellos G, Young R, Berard C, DeVita V. Results of combination chemotherapy of non-Hodgkin's lymphoma. British Journal Of Cancer. Supplement 1975, 2: 465-73. PMID: 1101932, PMCID: PMC2149606.Peer-Reviewed Original ResearchConceptsComplete remissionHodgkin's lymphomaCombination chemotherapyHistological subgroupsLymphocytic lymphomaMonths of treatmentDiffuse histiocytic lymphomaMOPP chemotherapyMedian durationLate recurrenceLymph nodesNodular histologyHistiocytic lymphomaRemissionExtended survivalBone marrowClinical validityLymphomaAdvanced stageChemotherapyPatientsRelapseInitial siteMonthsSurvivalPercutaneous liver biopsy, peritoneoscopy and laparotomy: an assessment of relative merits in the lymphomata.
Chabner B, Johnson R, Chretien P, Schein P, Young R, Canellos C, Hubbard S, Anderson T, Rosenoff S, DeVita V. Percutaneous liver biopsy, peritoneoscopy and laparotomy: an assessment of relative merits in the lymphomata. British Journal Of Cancer. Supplement 1975, 2: 242-7. PMID: 126693, PMCID: PMC2149568.Peer-Reviewed Original ResearchConceptsPercutaneous liver biopsyLiver biopsyLymphocytic lymphomaUntreated patientsHodgkin's lymphomaPercutaneous liver biopsy specimensStage IV diseaseConsecutive untreated patientsWedge liver biopsyLiver biopsy specimensLiver involvementPositive biopsiesBiopsy specimensPercutaneous biopsyLaparotomyPatientsBiopsyLymphomaPositive findingsTwo-thirdsFindingsDiseaseLiverNon‐Hodgkin's lymphoma: Patterns of relapse from complete remission after combination chemotherapy
Schein P, Chabner B, Canellos G, Young R, Devita V. Non‐Hodgkin's lymphoma: Patterns of relapse from complete remission after combination chemotherapy. Cancer 1975, 35: 354-357. PMID: 1089470, DOI: 10.1002/1097-0142(197502)35:2<354::aid-cncr2820350209>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsDiffuse histiocytic lymphomaComplete remissionLymphocytic lymphomaCombination chemotherapyHistiocytic lymphomaExtended disease-free survivalDisease-free survivalPatterns of relapseMonths of treatmentMaintenance chemotherapyRemission inductionLymph nodesLate recurrenceHistologic subgroupsHodgkin's lymphomaRemissionBone marrowLymphomaChemotherapyAggressive attemptsPatientsRelapseInitial siteTreatmentRecurrence
1974
Potential for Prolonged Disease-free Survival Following Combination Chemotherapy of Non-Hodgkin’s Lymphoma
Schein P, Chabner B, Canellos G, Young R, Berard C, DeVita V. Potential for Prolonged Disease-free Survival Following Combination Chemotherapy of Non-Hodgkin’s Lymphoma. Blood 1974, 43: 181-189. PMID: 4589318, DOI: 10.1182/blood.v43.2.181.181.Peer-Reviewed Original ResearchConceptsComplete remissionMedian survivalCombination chemotherapyHodgkin's lymphomaExtended disease-free survivalDisease-free survivalImproved median survivalNon-Hodgkin lymphomaMOPP chemotherapyMedian durationFurther therapyNodular histologyHistologic subgroupsDiffuse histologyHistologic categoriesNodular patternAggressive subgroupClinical validityLymphomaAdvanced stageRemissionChemotherapyEntire groupPatientsSignificant differences
1973
Diagnosis of liver involvement by lymphoma: Results in 96 consecutive peritoneoscopies
Bagley C, Thomas L, Johnson R, Chretien P, Devita V. Diagnosis of liver involvement by lymphoma: Results in 96 consecutive peritoneoscopies. Cancer 1973, 31: 840-847. PMID: 4267529, DOI: 10.1002/1097-0142(197304)31:4<840::aid-cncr2820310412>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseHepatic involvementLiver biopsyPositive biopsiesHodgkin's lymphomaLymphocytic lymphomaMultiple liver biopsiesMultiple needle biopsiesPresence of hepatomegalyLiver function testsPercutaneous liver biopsyUntreated Hodgkin's diseaseFrequent false-negative resultsPresence of symptomsFalse-negative resultsLiver involvementNodal diseaseWedge biopsyLymphomatous involvementFunction testsMinimal morbidityNeedle biopsyPercutaneous biopsySame patientBiopsy