2024
Sexual dimorphism in cortical theta rhythms relates to elevated internalizing symptoms during adolescence
Petro N, Picci G, Ott L, Rempe M, Embury C, Penhale S, Wang Y, Stephen J, Calhoun V, Taylor B, Wilson T. Sexual dimorphism in cortical theta rhythms relates to elevated internalizing symptoms during adolescence. Imaging Neuroscience 2024, 2: 1-13. DOI: 10.1162/imag_a_00062.Peer-Reviewed Original ResearchSpontaneous neural activityInternalizing symptomsNeural activityPsychiatric disordersEmergence of psychiatric disordersTheta activityEmergence of psychiatric symptomsAbstract Psychiatric disordersElevated internalizing symptomsStructural brain differencesTypically-developing youthSpontaneous theta activityEyes-closed restTheta frequency bandNegative ruminationCingulate cortexTemporoparietal junctionBrain differencesExternalizing symptomsPsychiatric symptomsAssociation cortexCortical regionsSex differencesCortical activityAssociation regions
2023
Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics
Picci G, Ott L, Penhale S, Taylor B, Johnson H, Willett M, Okelberry H, Wang Y, Calhoun V, Stephen J, Wilson T. Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics. Human Brain Mapping 2023, 44: 6043-6054. PMID: 37811842, PMCID: PMC10619376, DOI: 10.1002/hbm.26496.Peer-Reviewed Original ResearchConceptsCortical activityRobust sex differencesFunctional brain developmentTypically-developing youthSpontaneous cortical activityLowest relative powerCortical dynamicsEndogenous testosteronePrefrontal cortexExecutive functionFrontal cortexPubertal hormonesNeural circuitryResting-stateStructural MRIEffects of testosteroneSex differencesEffects of endogenous testosteroneDevelopmental changesBrain developmentReverse patternBehavioral changesGamma activityDevelopmental windowDevelopmental patterns