Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents
Picci G, Casagrande C, Ott L, Petro N, Christopher‐Hayes N, Johnson H, Willett M, Okelberry H, Wang Y, Stephen J, Calhoun V, Wilson T. Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents. Human Brain Mapping 2023, 44: 6388-6398. PMID: 37853842, PMCID: PMC10681633, DOI: 10.1002/hbm.26516.Peer-Reviewed Original ResearchConceptsTrauma-related symptomsAnxiety symptomsPituitary volumeAnterior pituitary volumeConsistent with adult findingsHigh-resolution T1-weighted MRI scansPG volumeEarly life stressLevels of dehydroepiandrosteroneT1-weighted MRI scansDehydroepiandrosterone levelsPituitary glandResponse to stressComorbid anxietyNeurobiological sequelaeSubclinical anxietyLife stressAnxiety/depression symptomsElevated anxietyAdult findingsAssociated with disruptionDevelopmental sampleHealthy youthTrained ratersPubertal windowDevelopmental alterations in the neural oscillatory dynamics underlying attentional reorienting
Picci G, Ott L, Petro N, Casagrande C, Killanin A, Rice D, Coutant A, Arif Y, Embury C, Okelberry H, Johnson H, Springer S, Pulliam H, Wang Y, Calhoun V, Stephen J, Heinrichs-Graham E, Taylor B, Wilson T. Developmental alterations in the neural oscillatory dynamics underlying attentional reorienting. Developmental Cognitive Neuroscience 2023, 63: 101288. PMID: 37567094, PMCID: PMC10432959, DOI: 10.1016/j.dcn.2023.101288.Peer-Reviewed Original ResearchConceptsAllocation of attentionBrain regionsFlexible allocation of attentionNetwork of brain regionsProtracted developmental coursePrefrontal brain regionsBrain-behavior associationsFronto-parietal networkHigher-order visual regionsNetwork of regionsAge-related improvementsTheta oscillatory activitySignificant oscillatory responsesNeural oscillatory dynamicsAttentional reorientingBehavioral performanceDevelopmental improvementCognitive processesDevelopmental courseHealthy youthTheta oscillationsVisual regionsMagnetoencephalography dataFunction of ageFlexible allocation