Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition
Feketa V, Balasubramanian A, Flores C, Player M, Marrelli S. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. AJP Regulatory Integrative And Comparative Physiology 2013, 305: r1040-r1050. PMID: 24005250, PMCID: PMC3840321, DOI: 10.1152/ajpregu.00296.2013.Peer-Reviewed Original ResearchConceptsTachycardic responsesTRPV1 activationMuscle activityCore temperatureTRPM8 inhibitionConscious stroke patientsRole of TRPM8TRPM8 KO miceTreatment of strokeElectromyographic muscle activityInduction of hypothermiaCold-induced shiveringTherapeutic hypothermiaStroke patientsConscious miceTRPV1 agonistsKO miceAbdominal cavityTachycardiaBack musclesEffective hypothermiaMild decreaseProfound dropShiveringHypothermiaAttenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels
Feketa V, Marrelli S. Attenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels. The FASEB Journal 2013, 27: 1201.27-1201.27. DOI: 10.1096/fasebj.27.1_supplement.1201.27.Peer-Reviewed Original ResearchCold-induced shiveringTRPV1 activationAfferent neural pathwaysCold-sensitive neuronsTRPM8 inhibitionCore temperatureTachycardic responsesTherapeutic hypothermiaAfferent pathwaysTRPM8 antagonistsCapsaicin receptorTRPM8 ion channelHeart rateMouse modelPharmacological modulationTachycardiaSkin warmingNeural pathwaysCombined treatmentShiveringTRPV1TRPM8 channelsIon channelsInhibitionComplete inhibition