2020
Lamellar cells in Pacinian and Meissner corpuscles are touch sensors
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6: eabe6393. PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.Peer-Reviewed Original ResearchLamellar cellsR-type voltage-gated calcium channelsMeissner corpusclesAction potentialsChannel-dependent action potentialsPacinian corpusclesVoltage-gated calcium channelsSensory afferent neuronsNon-neuronal cellsBill skinAfferent neuronsNeuronal afferentsCalcium channelsElectrophysiological recordingsTactile stimuliCorpusclesIon channelsCellsSkinFirst evidenceTactile organsAfferentsNeurons
2019
A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptors
2013
Attenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels
Feketa V, Marrelli S. Attenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels. The FASEB Journal 2013, 27: 1201.27-1201.27. DOI: 10.1096/fasebj.27.1_supplement.1201.27.Peer-Reviewed Original ResearchCold-induced shiveringTRPV1 activationAfferent neural pathwaysCold-sensitive neuronsTRPM8 inhibitionCore temperatureTachycardic responsesTherapeutic hypothermiaAfferent pathwaysTRPM8 antagonistsCapsaicin receptorTRPM8 ion channelHeart rateMouse modelPharmacological modulationTachycardiaSkin warmingNeural pathwaysCombined treatmentShiveringTRPV1TRPM8 channelsIon channelsInhibitionComplete inhibition