Attenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels
Feketa V, Marrelli S. Attenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels. The FASEB Journal 2013, 27: 1201.27-1201.27. DOI: 10.1096/fasebj.27.1_supplement.1201.27.Peer-Reviewed Original ResearchCold-induced shiveringTRPV1 activationAfferent neural pathwaysCold-sensitive neuronsTRPM8 inhibitionCore temperatureTachycardic responsesTherapeutic hypothermiaAfferent pathwaysTRPM8 antagonistsCapsaicin receptorTRPM8 ion channelHeart rateMouse modelPharmacological modulationTachycardiaSkin warmingNeural pathwaysCombined treatmentShiveringTRPV1TRPM8 channelsIon channelsInhibitionComplete inhibition