Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse
Feketa V, Zhang Y, Cao Z, Balasubramanian A, Flores C, Player M, Marrelli S. Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse. Critical Care Medicine 2014, 42: e355-e363. PMID: 24595220, PMCID: PMC4137592, DOI: 10.1097/ccm.0000000000000229.Peer-Reviewed Original ResearchConceptsTRP melastatin 8TRP vanilloid 1Transient receptor potential channelsConscious miceTRPM8 inhibitorTransient receptor potential vanilloid 1 (TRPV1) activationCore temperatureAged male miceProspective animal studyAcademic medical centerPotential channelsCerebral ischemiaLoading doseDose-dependent dropMechanical ventilationVanilloid 1TRPV1 agonistsCardiac arrestCold defense responsesContinuous infusionAged miceHypothermic effectTherapeutic rangeMale miceHypothermic response