2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsCatheterization, Central VenousChildChild, PreschoolCritical IllnessEnoxaparinFemaleHumansInfantMaleOutcome Assessment, Health CarePre-Exposure ProphylaxisThrombosisVenous ThrombosisConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potentialCurrent training in percutaneously inserted central catheter (PICC) placement and maintenance for neonatal–perinatal medicine fellows
Levit O, Shabanova V, Bizzarro MJ, Johnston L. Current training in percutaneously inserted central catheter (PICC) placement and maintenance for neonatal–perinatal medicine fellows. Journal Of Perinatology 2020, 40: 589-594. PMID: 31932714, DOI: 10.1038/s41372-019-0587-3.Peer-Reviewed Original ResearchMeSH KeywordsCatheterization, Central VenousCatheterization, PeripheralChi-Square DistributionClinical CompetenceCross-Sectional StudiesCurriculumEducation, Medical, GraduateEducational MeasurementFellowships and ScholarshipsHumansInfant, NewbornIntensive Care Units, NeonatalSurveys and QuestionnairesUnited StatesConceptsNeonatal-perinatal medicineNeonatal intensive care unitCentral catheter placementIntensive care unitNeonatal-perinatal medicine fellowsProgram directorsPICC insertionStudy designACare unitPICC placementPICC teamCatheter placementResponse rateMost program directorsConclusionsWide variationsEducational statusFormal trainingTraining program directorsCurrent educational status
2019
Impact of a dedicated nursing team on central line-related complications in neonatal intensive care unit
Levit O, Shabanova V, Bizzarro M. Impact of a dedicated nursing team on central line-related complications in neonatal intensive care unit. The Journal Of Maternal-Fetal & Neonatal Medicine 2019, 33: 2618-2622. PMID: 30612486, DOI: 10.1080/14767058.2018.1555814.Peer-Reviewed Original ResearchMeSH KeywordsCatheterization, Central VenousCatheter-Related InfectionsCentral Venous CathetersHumansInfantInfant, NewbornIntensive Care Units, NeonatalProspective StudiesConceptsLine-related complicationsCentral line-related complicationsDedicated nursing teamCentral line insertionNursing teamLine insertionProspective observational cohort studyNeonatal intensive care unitCatheter-related complicationsObservational cohort studyIntensive care unitNeonatal-perinatal medicine fellowsCentral line placementPost-intervention analysisCohort studyCentral cathetersCare unitCatheter maintenanceLine daysNeedle stickInsertion successComplicationsLine placementSignificant reductionPhlebitis
2016
Prediction of Catheter-Associated Thrombosis in Critically Ill Children
Marquez A, Shabanova V, Faustino EV. Prediction of Catheter-Associated Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2016, 17: e521-e528. PMID: 27662566, DOI: 10.1097/pcc.0000000000000958.Peer-Reviewed Original ResearchConceptsCatheter-associated thrombosisCentral venous cathetersVenous cathetersIll childrenRecent surgeryHigh riskCatheter-associated deep venous thrombosisMulticenter prospective cohort studyBlood product transfusionDeep venous thrombosisProspective cohort studyCritically Ill ChildrenSeverity of illnessRisk prediction modelProduct transfusionCohort studyVenous thrombosisGroup of childrenSubclavian veinActive surveillanceThrombosisCatheterSecondary analysisLogistic regressionCharacteristic curve
2011
“Change, before you have to.”–Jack Welch, Former CEO, General Electric*
Faustino EV, Lawson KA, Northrup V, Higgerson RA. “Change, before you have to.”–Jack Welch, Former CEO, General Electric*. Critical Care Medicine 2011, 40: 2227-2228. PMID: 21336130, PMCID: PMC3101274, DOI: 10.1097/ccm.0b013e31820eb8a1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCase-Control StudiesCatheterization, Central VenousCause of DeathChildChild, PreschoolCritical CareCritical IllnessFemaleHospital MortalityHumansInfantIntensive Care Units, PediatricMalePrognosisReference ValuesRespiration, ArtificialRetrospective StudiesRisk AssessmentSex FactorsSurvival AnalysisTime FactorsTreatment OutcomeVenous ThrombosisConceptsVentilator-free daysIntensive care unitCentral venous lineDeep venous thrombosisDeep vein thrombosisIndex patientsVenous thrombosisCare unitMechanical ventilationIll childrenControl patientsVein thrombosisVenous lineIntensive care unit-free daysIntensive care unit stayPrevious prospective observational studyPediatric intensive care unitCentral venous line insertionSymptomatic venous thromboembolismVenous thrombosis studyProspective observational studyAlternative outcome measuresUnit stayVenous thromboembolismCohort study
2010
A Quality Improvement Initiative to Reduce Central Line–Associated Bloodstream Infections in a Neonatal Intensive Care Unit
Bizzarro MJ, Sabo B, Noonan M, Bonfiglio MP, Northrup V, Diefenbach K. A Quality Improvement Initiative to Reduce Central Line–Associated Bloodstream Infections in a Neonatal Intensive Care Unit. Infection Control And Hospital Epidemiology 2010, 31: 241-248. PMID: 20102278, DOI: 10.1086/650448.Peer-Reviewed Original ResearchMeSH KeywordsCatheterization, Central VenousCatheters, IndwellingConnecticutCross InfectionHumansInfant, NewbornInfection ControlIntensive Care Units, NeonatalQuality Assurance, Health CareConceptsCentral line-associated bloodstream infectionsNeonatal intensive care unitLate-onset sepsisRate of CLABSINational Healthcare Safety NetworkCentral venous cathetersIntensive care unitCLABSI ratesBloodstream infectionsCare unitLevel III neonatal intensive care unitCentral Line–Associated Bloodstream InfectionsLine-associated bloodstream infectionsLine–Associated Bloodstream InfectionsEvidence-based guidelinesQuality improvement initiativesQuality improvement committeeCVC placementVenous cathetersNICU patientsInpatient careClinical practicePreintervention dataQuasi-experimental studySepsis