2021
Use of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children
Mahajerin A, Petty JK, Hanson SJ, Shabanova V, Faustino EVS. Use of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children. Journal Of Pediatric Hematology/Oncology 2021, 44: e349-e357. PMID: 33885041, DOI: 10.1097/mph.0000000000002167.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnticoagulantsChildHeparinHumansRetrospective StudiesRisk FactorsVenous ThromboembolismConceptsReceipt of prophylaxisRisk of VTEVenous thromboembolismInjured childrenRisk prediction modelPharmacologic prophylaxisTrauma Quality Improvement ProgramLow molecular weight heparinHospitalized injured patientsPediatric-specific evidencePractice management guidelinesRandomized clinical trialsMolecular weight heparinQuality Improvement ProgramUnfractionated heparinWeight heparinRetrospective studyInjured patientsClinical trialsProphylaxisManagement guidelinesThromboembolismPatientsHigh rateChildren
2020
The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females
Simpson S, Seifer DB, Shabanova V, Lynn AY, Howe C, Rowe E, Caprio S, Vash-Margita A. The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reproductive Biology And Endocrinology 2020, 18: 118. PMID: 33218348, PMCID: PMC7679991, DOI: 10.1186/s12958-020-00676-y.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeRotterdam diagnostic criteriaNon-PCOS groupMedian AMHOvarian syndromePCOS groupDiagnostic criteriaAnti-Müllerian hormone levelsAdolescent femalesRetrospective chart reviewTraditional clinical markersAnti-Müllerian hormoneCross-sectional studyWilcoxon rank sum testSignificant unadjusted differencesRank sum testD deficiencyChart reviewClinical featuresEndocrinology clinicSerum levelsAdjusted analysisUnadjusted comparisonsInsurance typeSurrogate markerRisks of venous thrombosis and bleeding in critically ill adolescents after trauma or major surgery
Hanson SJ, Mahajerin A, Petty JK, Shabanova V, Faustino EVS. Risks of venous thrombosis and bleeding in critically ill adolescents after trauma or major surgery. Journal Of Pediatric Surgery 2020, 56: 302-308. PMID: 32713711, DOI: 10.1016/j.jpedsurg.2020.06.037.Peer-Reviewed Original ResearchConceptsCentral venous catheterizationVenous thromboembolismMajor surgeryMechanical ventilationAnatomic sitesHigh riskIll adolescentsVirtual Pediatric Systems databasePediatric intensive care unitRisk of VTERetrospective cohort studyIntensive care unitMixed-effects logistic regressionEffects logistic regressionPharmacologic prophylaxisAdjusted riskCohort studyVenous thrombosisCare unitVenous catheterizationLower riskSurgeryLevel IILogistic regressionTrauma
2019
Epidemiology of Clinically Relevant Bleeding in Critically Ill Adolescents.
Pinto MG, Shabanova V, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Tala JA, Faustino EVS. Epidemiology of Clinically Relevant Bleeding in Critically Ill Adolescents. Pediatric Critical Care Medicine 2019, 20: 907-913. PMID: 31261231, DOI: 10.1097/pcc.0000000000002018.Peer-Reviewed Original ResearchConceptsRelevant bleedingVenous thromboembolismIll adolescentsPharmacologic prophylaxisHigh riskClinically Relevant BleedingMulticenter observational studyRandomized clinical trialsRisk of mortalityBleeding eventsTherapeutic anticoagulationMechanical ventilationPulmonary supportClinical trialsObservational studyThromboembolismBleedingAdolescents 13EpidemiologyStatistical significanceAnticoagulationProphylaxisSurgeryAdmissionAdolescentsVariable management strategies for NEC totalis: a national survey
Pyle AK, Shabanova V, Cleary MA, Ozgediz D, Cummings CL, Kamin DS, Mercurio MR. Variable management strategies for NEC totalis: a national survey. Journal Of Perinatology 2019, 39: 1521-1527. PMID: 31371831, DOI: 10.1038/s41372-019-0448-0.Peer-Reviewed Original ResearchConceptsLife-sustaining interventionsNEC totalisSignificant practice variabilityChi-square testVariable management strategiesNeonatal-perinatal medicineSurgical managementAAP SectionTreatment optionsMethodsAn anonymous surveyPediatric surgeryPractice variabilityTotalisSpearman correlationAnonymous surveySerious diseaseNational surveyMost respondentsWide variationEnterocolitisPrematuritySurgeryOptionsCounseling practiceConclusionsManagement
2018
Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections
Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin S, Aronson PL, Collaborative F, Nigrovic L, Browning W, Mitchell C, Peaper D, Feldman E. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal Of Pediatrics 2018, 204: 177-182.e1. PMID: 30297292, PMCID: PMC6309646, DOI: 10.1016/j.jpeds.2018.08.066.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsFebrile young infantsAdverse outcomesBacterial meningitisYoung infantsIll appearanceFebrile infantsBacterial infectionsRetrospective cohort studyMedical record reviewLocal microbiology laboratoryMixed-effects logistic regressionElectronic medical record systemDays of ageIll appearingNeurologic sequelaeCohort studyMedical record systemClinical factorsMedication receiptMechanical ventilationRecord reviewClinical dataInclusion criteriaMeningitisEpidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents
Faustino EVS, Shabanova V, Pinto MG, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Napolitano M, Brudnicki AR, Tala JA, Silva CT, Investigators T, Miksa M, Taragin B, Blickman J, Taillie E, Trakas E, Balasco A, Herliczek T, Polikoff L, Dovi G, Napolitano M, Gertz S, Riordan M, Zasa J, Brudnicki A, Eldridge P, Li S, Pinto M, Faustino E, Silva C, Tala J. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents. The Journal Of Pediatrics 2018, 201: 176-183.e2. PMID: 29891258, DOI: 10.1016/j.jpeds.2018.05.006.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisExtremity deep venous thrombosisIll adolescentsVenous thrombosisFrequency of DVTLower extremity deep venous thrombosisCases of DVTBilateral deep venous thrombosisPediatric intensive care unitInvasive mechanical ventilationCentral venous catheterizationIntensive care unitPharmacologic prophylaxisTherapeutic anticoagulationCohort studyPulmonary embolismCardiopulmonary supportCare unitMechanical ventilationVenous catheterizationSevere illnessSerial sonogramsLower extremitiesEpidemiologyThrombosis
2017
Ventricular arrhythmias immediately following transcatheter pulmonary valve implantation: A cause for concern?
Simmons MA, Elder RW, Shabanova V, Hellenbrand W, Asnes J. Ventricular arrhythmias immediately following transcatheter pulmonary valve implantation: A cause for concern? Catheterization And Cardiovascular Interventions 2017, 91: 920-926. PMID: 29280541, DOI: 10.1002/ccd.27454.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve implantationRight ventricular outflow tractNative outflow tractsSignificant ventricular arrhythmiasPulmonary valve implantationVentricular arrhythmiasOutflow tractValve implantationAnti-arrhythmic medicationsBeta-blocker therapySingle-center studyVentricular outflow tractLong-term therapySudden cardiac deathCare of patientsChange of doseHemodynamic instabilityHemodynamic compromiseCardiac deathMedian ageMedical therapyPediatric patientsSignificant arrhythmiasCenter studyTerm therapyRisk factors for tracheostomy requirement in extremely low birth weight infants
Levit OL, Shabanova V, Bazzy-Asaad A, Bizzarro MJ, Bhandari V. Risk factors for tracheostomy requirement in extremely low birth weight infants. The Journal Of Maternal-Fetal & Neonatal Medicine 2017, 31: 447-452. PMID: 28139937, DOI: 10.1080/14767058.2017.1287895.Peer-Reviewed Original ResearchMeSH KeywordsAirway ExtubationCase-Control StudiesFemaleGestational AgeHumansInfantInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornIntubation, IntratrachealMalePregnancyRespiration, ArtificialRetrospective StudiesRisk FactorsSeverity of Illness IndexTime FactorsTracheostomyConceptsLow birth weight infantsOdds of tracheostomyBirth weight infantsELBW infantsWeight infantsEndotracheal tubeRisk of tracheostomyPresence of comorbiditiesUse of steroidsCase-control studyConditional logistic regressionNumber of intubationsGreater cumulative exposureIntubation episodesTracheostomy requirementExtubation attemptGestational ageEpisodes/Risk factorsTracheostomyPrevious episodesCumulative exposurePoisson regressionCumulative daysInfants
2014
Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis
Levit O, Bhandari V, Li FY, Shabanova V, Gallagher PG, Bizzarro MJ. Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis. The Pediatric Infectious Disease Journal 2014, 33: 143-146. PMID: 24418836, PMCID: PMC3917323, DOI: 10.1097/inf.0000000000000024.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsIndependent risk factorLaboratory factorsWeight infantsVLBW infantsRisk factorsCases of LOSEpisodes of LOSRisk of LOSFungal LOSNeonatal intensive care unitMultivariate logistic regression analysisSepsis-related deathsIntensive care unitOnset of illnessSepsis-associated mortalityGram-positive infectionsLogistic regression analysisOnset of diseasePresentation of illnessComposite risk profileLaboratory signsNecrotizing enterocolitis
2013
Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
Lygizos M, Shenoi SV, Brooks RP, Bhushan A, Brust J, Zelterman D, Deng Y, Northrup V, Moll AP, Friedland GH. Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa. BMC Infectious Diseases 2013, 13: 300. PMID: 23815441, PMCID: PMC3716713, DOI: 10.1186/1471-2334-13-300.Peer-Reviewed Original ResearchConceptsTB transmission riskInfectious TB patientsTransmission riskTB patientsRural South AfricaDrug-resistant TBTB control effortsHealth care facilitiesPaucity of dataHousehold settingsRural KwaZulu-NatalPrevalent TBResistant TBTB transmissionCare facilitiesMultivariate analysisHIV areasVentilationAChSignificant decreaseWells-Riley equationPatientsRiskLow ventilationHour period
2011
Antibiotic Exposure in the Newborn Intensive Care Unit and the Risk of Necrotizing Enterocolitis
Alexander VN, Northrup V, Bizzarro MJ. Antibiotic Exposure in the Newborn Intensive Care Unit and the Risk of Necrotizing Enterocolitis. The Journal Of Pediatrics 2011, 159: 392-397. PMID: 21489560, PMCID: PMC3137655, DOI: 10.1016/j.jpeds.2011.02.035.Peer-Reviewed Original ResearchConceptsRisk of NECAntibiotic exposureControl subjectsRisk factorsNewborn intensive care unitCulture-proven sepsisFull enteral feedingCases of NECIndependent risk factorDiagnosis of NECRespiratory distress syndromeIntensive care unitRisk factor dataPrior sepsisEnteral feedingNecrotizing enterocolitisDistress syndromeCare unitGestational ageBirth weightAntibiotic useCase subjectsSepsisMultivariate analysisNeonates
2010
High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation
O’Malley G, Santoro N, Northrup V, D’Adamo E, Shaw M, Eldrich S, Caprio S. High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation. Diabetologia 2010, 53: 1199-1209. PMID: 20204321, DOI: 10.1007/s00125-010-1693-0.Peer-Reviewed Original ResearchConceptsBeta-cell functionPlasma glucosePlasma glucose levelsInsulin sensitivityObese youthGlucose levelsType 2 diabetes mellitusConclusions/interpretationThese dataAdverse cardiovascular profileAims/hypothesisAImpaired glucose toleranceCell functionBMI z-scoreCross-sectional analysisAUC 2Standard OGTTCardiovascular profileDiabetes mellitusGlucose toleranceH glucoseInsulin resistanceRisk factorsInterpretationThese dataCardiovascular diseaseCell dysregulation