2022
Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer.
Kowalchuk R, Niranjan A, Hess J, Antonios J, Zhang M, Braunstein S, Ross R, Pikis S, Deibert C, Lee C, Yang H, Langlois A, Mathieu D, Peker S, Samanci Y, Rusthoven C, Chiang V, Wei Z, Lunsford L, Trifiletti D, Sheehan J. Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer. Journal Of Neurosurgery 2022, 138: 1608-1614. PMID: 36433878, DOI: 10.3171/2022.10.jns221900.Peer-Reviewed Original ResearchTriple-negative breast cancerLocal tumor progressionStereotactic radiosurgeryBreast cancerOverall survivalMetastatic lesionsPerformance statusLocal controlTriple-negative breast cancer metastasisMedian Karnofsky performance statusTumor progressionWhole-brain radiation therapyFavorable performance statusMedian margin dosePrior stereotactic radiosurgerySymptomatic radiation necrosisKarnofsky performance statusIntracranial metastatic diseaseRetrospective chart reviewLocal tumor controlBreast cancer metastasisIntracranial metastatic lesionsMargin doseMultiinstitutional cohortBrain metastases
2020
Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases
Robert S, Chiang V. Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases. 2020, 393-405. DOI: 10.1007/978-3-030-42958-4_28.ChaptersMetastatic brain lesionsRadiation necrosisBrain lesionsStereotactic radiosurgeryRadiation-induced side effectsImmune system involvementEffective treatment modalityMetastatic intracranial tumorsBrain metastasesSystemic cancerTreatment modalitiesUnderlying pathophysiologySystem involvementDisease entityIntracranial tumorsRadiosurgical treatmentSide effectsTumor progressionBrain tissueNecrosisConcurrent useLesionsRadiosurgeryImaging modalitiesLife expectancy
2016
Possible Interaction of Anti–PD-1 Therapy with the Effects of Radiosurgery on Brain Metastases
Alomari AK, Cohen J, Vortmeyer AO, Chiang A, Gettinger S, Goldberg S, Kluger HM, Chiang VL. Possible Interaction of Anti–PD-1 Therapy with the Effects of Radiosurgery on Brain Metastases. Cancer Immunology Research 2016, 4: 481-487. PMID: 26994250, DOI: 10.1158/2326-6066.cir-15-0238.Peer-Reviewed Original ResearchConceptsStereotactic radiosurgeryBrain metastasesInitiation of immunotherapyPD-1 mAbImmune-modulating therapyModalities of treatmentRadiologic progressionSurgical resectionSystemic therapyDeath-1Radiologic findingsMetastatic malignancyReactive astrocytosisPathologic examinationTreatment regimensHistopathologic examinationWall infiltrationT lymphocytesPatientsTumor progressionMonoclonal antibodiesBiologic interactionsRadiation-induced changesImmunotherapyMalignancy
2015
Gamma Knife radiosurgery for posterior fossa meningiomas: a multicenter study.
Sheehan JP, Starke RM, Kano H, Barnett GH, Mathieu D, Chiang V, Yu JB, Hess J, McBride HL, Honea N, Nakaji P, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD. Gamma Knife radiosurgery for posterior fossa meningiomas: a multicenter study. Journal Of Neurosurgery 2015, 122: 1479-89. PMID: 25859812, DOI: 10.3171/2014.10.jns14139.Peer-Reviewed Original ResearchConceptsPosterior fossa meningiomasTumor volumeStereotactic radiosurgeryTumor controlRadiation therapyNorth American Gamma Knife ConsortiumTumor progressionActuarial tumor controlMedian margin doseMedian patient agePrior radiation therapyMean tumor volumeGamma knife radiosurgerySmaller tumor volumeNeurological preservationMargin dosePrior resectionClinical stabilityNeurological declinePatient ageShunt placementRecurrent tumorsClinical entityMulticenter studyKnife radiosurgery
2014
Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study
Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study. Neurosurgery 2014, 75: 398-408. PMID: 24991710, DOI: 10.1227/neu.0000000000000480.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryCerebellopontine angle meningiomaNeurological deteriorationCPA meningiomasKnife radiosurgeryNorth American Gamma Knife ConsortiumSymptomatic adverse radiation effectsTumor progressionLower maximal dosePermanent neurological deteriorationCommon presenting symptomInitial surgical resectionMulticenter cohort studyOutcomes of patientsProgression-free survivalSignificant neurological morbidityMedian tumor volumeAdverse radiation effectsMultivariate regression analysisAdjuvant treatmentNeurological morbidityPresenting symptomCohort studyMost patientsSurgical resectionGamma Knife radiosurgery for sellar and parasellar meningiomas: a multicenter study.
Sheehan JP, Starke RM, Kano H, Kaufmann AM, Mathieu D, Zeiler FA, West M, Chao ST, Varma G, Chiang VL, Yu JB, McBride HL, Nakaji P, Youssef E, Honea N, Rush S, Kondziolka D, Lee JY, Bailey RL, Kunwar S, Petti P, Lunsford LD. Gamma Knife radiosurgery for sellar and parasellar meningiomas: a multicenter study. Journal Of Neurosurgery 2014, 120: 1268-77. PMID: 24678777, DOI: 10.3171/2014.2.jns13139.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryPrior radiation therapyParasellar meningiomasSellar meningiomasKnife radiosurgeryRadiation therapyPrior surgeryMulticenter studyTumor controlTumor volumeActuarial progression-free survival ratesNorth American Gamma Knife ConsortiumTumor progressionProgression-free survival ratesCox multivariate regression analysisTumor margin doseNew neurological deficitsCranial nerve deficitsPrimary treatment modalityKaplan-Meier analysisCranial nerves VLarger tumor volumeConventional radiation therapyMonths of imagingMultivariate regression analysis