2018
SURG-20. LASER-INTERSTITIAL THERMAL THERAPY VERSUS CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY
Hong C, Deng J, Vera A, Chiang V. SURG-20. LASER-INTERSTITIAL THERMAL THERAPY VERSUS CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY. Neuro-Oncology 2018, 20: vi254-vi255. PMCID: PMC6216306, DOI: 10.1093/neuonc/noy148.1056.Peer-Reviewed Original ResearchLaser interstitial thermal therapyProgression-free survivalRe-growing tumorRadiation necrosisBrain metastasesMelanoma patientsSingle-surgeon retrospective studyImproved progression-free survivalLocal progression-free survivalPre-operative symptomsLog-rank testSteroid dosingSteroid taperNeurological outcomeOverall survivalRecurrent tumorsUnderwent craniotomyRetrospective studySingle institutionSubgroup analysisSurgery dateSurvival advantageCraniotomyPatientsLocal control
2016
Timing and type of immune checkpoint therapy affect the early radiographic response of melanoma brain metastases to stereotactic radiosurgery
Qian JM, Yu JB, Kluger HM, Chiang VL. Timing and type of immune checkpoint therapy affect the early radiographic response of melanoma brain metastases to stereotactic radiosurgery. Cancer 2016, 122: 3051-3058. PMID: 27285122, PMCID: PMC5030143, DOI: 10.1002/cncr.30138.Peer-Reviewed Original ResearchConceptsMedian percent reductionImmune checkpoint therapyLesional responseStereotactic radiosurgeryCheckpoint therapyLesion volumeAnti-cytotoxic T-lymphocyte-associated protein 4Anti-programmed cell death protein 1T-lymphocyte-associated protein 4Anti-PD-1 therapyGreater median percent reductionsCell death protein 1Administration of immunotherapyWeeks of immunotherapyMelanoma brain metastasesDeath protein 1Type of immunotherapyWilcoxon rank sum testRank sum testNonconcurrent therapyBrain metastasesMelanoma patientsTreatment of cancerSingle institutionPercent reduction
2000
Toward more rational prediction of outcome in patients with high-grade subarachnoid hemorrhage.
Chiang V, Claus E, Awad I. Toward more rational prediction of outcome in patients with high-grade subarachnoid hemorrhage. Neurosurgery 2000, 46: 28-35; discussion 35-6. PMID: 10626932, DOI: 10.1097/00006123-200001000-00006.Peer-Reviewed Original ResearchConceptsGlasgow Coma ScaleHigh-grade subarachnoid hemorrhageWorse clinical gradeSubarachnoid hemorrhageHess scaleOutcome predictionWFNS scaleMultivariate analysisPoor outcome groupGlasgow Outcome ScaleClinical grading scaleNeurological Surgeons (WFNS) scalePretreatment gradeComa ScaleConsecutive patientsKarnofsky scalePoor outcomeSingle institutionAccurate outcome predictionClinical examinationOutcome ScaleFavorable outcomeMental statusOutcome groupClinical grade