2022
Synchronous glioblastoma and brain metastases: illustrative case
Shahsavari N, Ahmad M, Sekar V, Meola A, Hancock SL, Chang SD, Chiang VL. Synchronous glioblastoma and brain metastases: illustrative case. Journal Of Neurosurgery Case Lessons 2022, 3: case21714. PMID: 36273867, PMCID: PMC9379681, DOI: 10.3171/case21714.Peer-Reviewed Original ResearchBrain metastasesMultiple brain metastasesRadiosurgical treatmentSignificant perilesional edemaSimilar radiological featuresMetastatic lung adenocarcinomaRight temporal lobeStereotactic radiosurgical treatmentMaintenance nivolumabRadiological featuresMidline shiftPerilesional edemaTreatment courseTissue confirmationLung adenocarcinomaStereotactic radiosurgeryTemporal lobeMetastasisIllustrative caseIncorrect diagnosisRadiological surveillanceSynchronous presenceIDH-wildtypeGlioblastomaLesions
2020
Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases
Robert S, Chiang V. Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases. 2020, 393-405. DOI: 10.1007/978-3-030-42958-4_28.ChaptersMetastatic brain lesionsRadiation necrosisBrain lesionsStereotactic radiosurgeryRadiation-induced side effectsImmune system involvementEffective treatment modalityMetastatic intracranial tumorsBrain metastasesSystemic cancerTreatment modalitiesUnderlying pathophysiologySystem involvementDisease entityIntracranial tumorsRadiosurgical treatmentSide effectsTumor progressionBrain tissueNecrosisConcurrent useLesionsRadiosurgeryImaging modalitiesLife expectancyLaser Interstitial Thermotherapy for Treatment of Symptomatic Peritumoral Edema After Radiosurgery for Meningioma
Hong CS, Beckta JM, Kundishora AJ, Elsamadicy AA, Chiang VL. Laser Interstitial Thermotherapy for Treatment of Symptomatic Peritumoral Edema After Radiosurgery for Meningioma. World Neurosurgery 2020, 136: 295-300. PMID: 32001396, DOI: 10.1016/j.wneu.2020.01.143.Peer-Reviewed Original ResearchConceptsSymptomatic peritumoral edemaPeritumoral edemaLaser interstitial thermotherapySurgical resectionGrade IOpen surgical resectionEffective therapeutic modalityViable alternative treatmentInterstitial thermotherapyExperienced resolutionCorticosteroid therapyIntraoperative biopsyRefractory casesConservative managementMost patientsLesion recurrenceMedical therapyRadiation necrosisUnderlying lesionSurgical interventionWound infectionTherapeutic modalitiesRadiosurgical treatmentAlternative treatmentFrontotemporal lesions
2015
Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases?
Colaco RJ, Martin P, Kluger HM, Yu JB, Chiang VL. Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases? Journal Of Neurosurgery 2015, 125: 17-23. PMID: 26544782, DOI: 10.3171/2015.6.jns142763.Peer-Reviewed Original ResearchConceptsTreatment-related imaging changesCytotoxic chemotherapyRadiation necrosisBrain metastasesSystemic therapyStereotactic Gamma Knife radiosurgeryMedian overall survivalGamma knife radiosurgeryHigh-dose radiationChemotherapy eraGK surgeryImmunotherapy increasesMedian followConclusions PatientsOverall survivalImaging changesGK treatmentKnife radiosurgeryInflammatory reactionStereotactic radiosurgeryLower riskRadiosurgical treatmentPatientsImmunotherapyTherapyPrognostic Factors for Seizures After First Radiosurgical Treatment in Patients With Brain Metastases
Jairam V, Chiang V, Yu J. Prognostic Factors for Seizures After First Radiosurgical Treatment in Patients With Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e100. DOI: 10.1016/j.ijrobp.2015.07.802.Peer-Reviewed Original ResearchEquivalent whole brain dose for patients undergoing gamma knife for multiple lesions.
Jairam V, Chiang VL, Bond J, Yu JB. Equivalent whole brain dose for patients undergoing gamma knife for multiple lesions. Journal Of Radiosurgery And SBRT 2015, 3: 187-191. PMID: 29296401, PMCID: PMC5746333.Peer-Reviewed Original ResearchWhole-brain doseTotal tumor volumeMultiple lesionsTumor volumeBrain doseMedian total tumor volumeCumulative tumor volumeWhole brain dosesWhole brain radiotherapyTreatment of patientsBrain metastasesBrain radiotherapyIndividualized treatment planningTumor numberBrain dosesInstitutional databaseTumor locationMedian numberRadiosurgical treatmentPatientsRepresentative patientsLesionsEntire brainVital structuresGamma Knife