2021
Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF)
Cifarelli C, Vargo J, Fang W, Liscak R, Guseynova K, Warnick R, Lee C, Yang H, Borghei-Razavi H, Maiti T, Siddiqui Z, Yuan J, Grills I, Mathieu D, Touchette C, Cordeiro D, Chiang V, Hess J, Tien C, Faramand A, Kano H, Barnett G, Sheehan J, Lunsford L. Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF). Neurosurgery 2021, 89: s20-s20. DOI: 10.1093/neuros/nyz428_s020.Peer-Reviewed Original Research
2019
Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF)
Cifarelli CP, Vargo JA, Fang W, Liscak R, Guseynova K, Warnick RE, Lee CC, Yang HC, Borghei-Razavi H, Maiti T, Siddiqui ZA, Yuan JC, Grills IS, Mathieu D, Touchette CJ, Cordeiro D, Chiang V, Hess J, Tien CJ, Faramand A, Kano H, Barnett GH, Sheehan JP, Lunsford LD. Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF). Neurosurgery 2019, 87: 664-671. PMID: 31599324, PMCID: PMC7780439, DOI: 10.1093/neuros/nyz428.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerWhole-brain irradiationSCLC brain metastasesInternational Radiosurgery Research FoundationDistant brain failureBrain metastasesOverall survivalStereotactic radiosurgerySCLC patientsBrain failureLung cancerPrior whole-brain irradiationMulti-institutional retrospective reviewKaplan-Meier survival analysisCox proportional hazards modelLocal failureProphylactic cranial irradiationInstitutional retrospective studyMedian marginal doseOngoing prospective trialsCell lung cancerGamma knife radiosurgeryInstitutional review boardValue of radiosurgeryBinary logistic regressionHemorrhage risk of cerebral dural arteriovenous fistulas following Gamma Knife radiosurgery in a multicenter international consortium.
Starke RM, McCarthy DJ, Chen CJ, Kano H, McShane BJ, Lee J, Patibandla MR, Mathieu D, Vasas LT, Kaufmann AM, Wang WG, Grills IS, Cifarelli CP, Paisan G, Vargo J, Chytka T, Janouskova L, Feliciano CE, Sujijantarat N, Matouk C, Chiang V, Hess J, Rodriguez-Mercado R, Tonetti DA, Lunsford LD, Sheehan JP. Hemorrhage risk of cerebral dural arteriovenous fistulas following Gamma Knife radiosurgery in a multicenter international consortium. Journal Of Neurosurgery 2019, 132: 1209-1217. PMID: 30875690, PMCID: PMC6745287, DOI: 10.3171/2018.12.jns182208.Peer-Reviewed Original ResearchCerebral dural arteriovenous fistulasDural arteriovenous fistulaGamma knife radiosurgeryCortical venous drainageEndovascular treatmentArteriovenous fistulaKnife radiosurgeryRisk factorsAnnual riskLatency periodType 2Multivariate analysisInternational Radiosurgery Research FoundationCohort of patientsNumber of hemorrhagesOverall annual riskPosttreatment hemorrhage rateIndependent predictorsRadiological confirmationHemorrhage rateHemorrhage riskHemorrhagic rateVenous drainageNeural deficitsHigh riskResults of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.Peer-Reviewed Original ResearchYale-New Haven HospitalPhase II studyBrain metastasesClinical trialsII studyKnife radiosurgeryLocal controlPre-defined primary endpointWhole-brain radiation treatmentFuture prospective clinical trialsEvaluable brain metastasesSymptomatic radiation necrosisMedian patient ageLocal control ratePhase 2 studyGood local controlProspective clinical trialsNumber of metastasesLarge clinical trialsProportional hazards regressionFuture clinical trialsGamma knife radiosurgeryImportant clinical variablesStandard clinical practiceNew Haven Hospital
2018
Breast cancer patients with brain metastasis undergoing GKRS
Abu-Khalaf M, Muralikrishnan S, Hatzis C, Canchi D, Yu JB, Chiang V. Breast cancer patients with brain metastasis undergoing GKRS. Breast Cancer 2018, 26: 147-153. PMID: 30182250, DOI: 10.1007/s12282-018-0903-3.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyGamma knife radiosurgeryKarnofsky performance statusBrain metastasesOverall survivalBackgroundBreast cancerSurgical resectionTime of GKRSFirst gamma knife radiosurgeryFirst GKRS treatmentBrain radiation therapyBreast cancer patientsComprehensive cancer centerGKRS treatmentNeurocognitive preservationResultsMedian agePerformance statusMethodsThe recordsNeurological deathSuch patientsMultivariable analysisRetrospective studySurvival outcomesSystemic diseaseCancer Center
2016
The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery.
Kann BH, Yu JB, Stahl JM, Bond JE, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery. Journal Of Neurosurgery 2016, 125: 154-159. PMID: 27903196, DOI: 10.3171/2016.6.gks161497.Peer-Reviewed Original ResearchConceptsTrigeminal neuralgiaGKRS treatmentObsessive-compulsive disorderTN managementEffective doseRefractory obsessive-compulsive disorderGamma Knife radiosurgery proceduresStudy of patientsGamma knife radiosurgeryRates of toxicitySingle-fraction dosesStudy of outcomesNerve ablationSerious sequelaePrescription dosesKnife radiosurgeryPrescription doseClinical studiesConclusion UseGKRSDose prescriptionGy/minRepair halftimeTreatment timeAuthors' departmentNovel biomarker identification using metabolomic profiling to differentiate radiation necrosis and recurrent tumor following Gamma Knife radiosurgery.
Lu AY, Turban JL, Damisah EC, Li J, Alomari AK, Eid T, Vortmeyer AO, Chiang VL. Novel biomarker identification using metabolomic profiling to differentiate radiation necrosis and recurrent tumor following Gamma Knife radiosurgery. Journal Of Neurosurgery 2016, 127: 388-396. PMID: 27885954, DOI: 10.3171/2016.8.jns161395.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryRadiation necrosisRecurrent tumorsKnife radiosurgeryBrain metastasesSamples of tumorMetabolic imaging techniquesMetabolite profilesUnique metabolite profilesNovel biomarker identificationBrain biopsyPure tumorEnhancing lesionsSurgical biopsyLevels of metabolitesTumorsNecrosisTumor samplesDifferential metabolite profilesElevated levelsRadiosurgeryNoninvasive imagingComparison groupTissue samplesMetabolomic profiling
2015
Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases?
Colaco RJ, Martin P, Kluger HM, Yu JB, Chiang VL. Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases? Journal Of Neurosurgery 2015, 125: 17-23. PMID: 26544782, DOI: 10.3171/2015.6.jns142763.Peer-Reviewed Original ResearchConceptsTreatment-related imaging changesCytotoxic chemotherapyRadiation necrosisBrain metastasesSystemic therapyStereotactic Gamma Knife radiosurgeryMedian overall survivalGamma knife radiosurgeryHigh-dose radiationChemotherapy eraGK surgeryImmunotherapy increasesMedian followConclusions PatientsOverall survivalImaging changesGK treatmentKnife radiosurgeryInflammatory reactionStereotactic radiosurgeryLower riskRadiosurgical treatmentPatientsImmunotherapyTherapyGamma Knife radiosurgery for facial nerve schwannomas: a multicenter study.
Sheehan JP, Kano H, Xu Z, Chiang V, Mathieu D, Chao S, Akpinar B, Lee JY, Yu JB, Hess J, Wu HM, Chung WY, Pierce J, Missios S, Kondziolka D, Alonso-Basanta M, Barnett GH, Lunsford LD. Gamma Knife radiosurgery for facial nerve schwannomas: a multicenter study. Journal Of Neurosurgery 2015, 123: 387-94. PMID: 25955875, DOI: 10.3171/2014.11.jns141160.Peer-Reviewed Original ResearchConceptsFacial nerve schwannomaFacial nerve functionNorth American Gamma Knife ConsortiumHouse-Brackmann scoreStereotactic radiosurgeryNerve functionTumor controlNeurological preservationMargin doseMedian ageNerve schwannomaPreoperative facial nerve functionNormal facial nerve functionResidual/recurrent tumorActuarial tumor controlEffective salvage treatmentMean margin dosePermanent neurological symptomsTumor margin doseUpfront stereotactic radiosurgeryPatients' median ageMean tumor volumeTreatment of choiceGamma knife radiosurgeryRare intracranial tumorsGamma Knife radiosurgery for posterior fossa meningiomas: a multicenter study.
Sheehan JP, Starke RM, Kano H, Barnett GH, Mathieu D, Chiang V, Yu JB, Hess J, McBride HL, Honea N, Nakaji P, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD. Gamma Knife radiosurgery for posterior fossa meningiomas: a multicenter study. Journal Of Neurosurgery 2015, 122: 1479-89. PMID: 25859812, DOI: 10.3171/2014.10.jns14139.Peer-Reviewed Original ResearchConceptsPosterior fossa meningiomasTumor volumeStereotactic radiosurgeryTumor controlRadiation therapyNorth American Gamma Knife ConsortiumTumor progressionActuarial tumor controlMedian margin doseMedian patient agePrior radiation therapyMean tumor volumeGamma knife radiosurgerySmaller tumor volumeNeurological preservationMargin dosePrior resectionClinical stabilityNeurological declinePatient ageShunt placementRecurrent tumorsClinical entityMulticenter studyKnife radiosurgery
2014
Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study
Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study. Neurosurgery 2014, 75: 398-408. PMID: 24991710, DOI: 10.1227/neu.0000000000000480.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryCerebellopontine angle meningiomaNeurological deteriorationCPA meningiomasKnife radiosurgeryNorth American Gamma Knife ConsortiumSymptomatic adverse radiation effectsTumor progressionLower maximal dosePermanent neurological deteriorationCommon presenting symptomInitial surgical resectionMulticenter cohort studyOutcomes of patientsProgression-free survivalSignificant neurological morbidityMedian tumor volumeAdverse radiation effectsMultivariate regression analysisAdjuvant treatmentNeurological morbidityPresenting symptomCohort studyMost patientsSurgical resectionSystemic Treatment and Radiation Necrosis Following Gamma Knife Radiosurgery in the Treatment of Brain Metastases
Colaco R, Martin P, Bond J, Bindra R, Contessa J, Kluger H, Yu J, Chiang V. Systemic Treatment and Radiation Necrosis Following Gamma Knife Radiosurgery in the Treatment of Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s310. DOI: 10.1016/j.ijrobp.2014.05.1035.Peer-Reviewed Original ResearchGamma knife radiosurgeryBrain metastasesSystemic treatmentKnife radiosurgeryTreatmentMetastasisRadiosurgeryStereotactic radiosurgery of petroclival meningiomas: a multicenter study
Starke R, Kano H, Ding D, Nakaji P, Barnett GH, Mathieu D, Chiang V, Yu JB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Stereotactic radiosurgery of petroclival meningiomas: a multicenter study. Journal Of Neuro-Oncology 2014, 119: 169-176. PMID: 24821284, DOI: 10.1007/s11060-014-1470-x.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryPetroclival meningiomasMulticenter studyFavorable outcomeTumor volumeActuarial progression-free survival ratesNorth American Gamma Knife ConsortiumProgression-free survival ratesFree survival ratePrimary treatment modalityProgression of symptomsSmaller tumor volumeComplete microsurgical resectionNeurological preservationUpfront radiosurgeryPrior radiotherapyMost patientsMicrosurgical resectionSignificant morbidityNeurological functionMaximal doseTumor controlTreatment modalitiesKnife radiosurgeryFemale genderGamma Knife radiosurgery for sellar and parasellar meningiomas: a multicenter study.
Sheehan JP, Starke RM, Kano H, Kaufmann AM, Mathieu D, Zeiler FA, West M, Chao ST, Varma G, Chiang VL, Yu JB, McBride HL, Nakaji P, Youssef E, Honea N, Rush S, Kondziolka D, Lee JY, Bailey RL, Kunwar S, Petti P, Lunsford LD. Gamma Knife radiosurgery for sellar and parasellar meningiomas: a multicenter study. Journal Of Neurosurgery 2014, 120: 1268-77. PMID: 24678777, DOI: 10.3171/2014.2.jns13139.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryPrior radiation therapyParasellar meningiomasSellar meningiomasKnife radiosurgeryRadiation therapyPrior surgeryMulticenter studyTumor controlTumor volumeActuarial progression-free survival ratesNorth American Gamma Knife ConsortiumTumor progressionProgression-free survival ratesCox multivariate regression analysisTumor margin doseNew neurological deficitsCranial nerve deficitsPrimary treatment modalityKaplan-Meier analysisCranial nerves VLarger tumor volumeConventional radiation therapyMonths of imagingMultivariate regression analysisRadiologic and histologic consequences of radiosurgery for brain tumors
Alomari A, Rauch PJ, Orsaria M, Minja FJ, Chiang VL, Vortmeyer AO. Radiologic and histologic consequences of radiosurgery for brain tumors. Journal Of Neuro-Oncology 2014, 117: 33-42. PMID: 24442402, DOI: 10.1007/s11060-014-1359-8.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryNon-enhancing regionsNon-enhancing areasRecurrent tumorsEncephalopathic changesBrain lesionsRecurrent tumor growthMalignant brain lesionsGadolinium-enhanced MRIHigh clinical relevanceDemyelinating changesSeparate biopsiesNon-enhancing componentsInflammatory demyelinationRadiological changesHistologic consequencesImaging changesReactive astrocytosisHistopathological changesKnife radiosurgeryPathological changesCoagulative necrosisBrain tumorsClinical relevanceHistological results
2013
Rapidly Progressive Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Vestibular Nerve
Kuzmik GA, Michaelides EM, Chiang VL, Nonaka Y, Fukushima T, Vortmeyer AO, Bulsara KR. Rapidly Progressive Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Vestibular Nerve. Otology & Neurotology 2013, 34: 1739-1742. PMID: 23988994, DOI: 10.1097/mao.0b013e31829ab8be.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorEpithelioid malignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsMagnetic resonance imagingNerve sheath tumorsVestibular nerveSheath tumorsMalignant natureInternal auditory canal massRepeat magnetic resonance imagingGood initial optionSubsequent microsurgical resectionFacial nerve palsyAtypical clinical courseGamma knife radiosurgerySensorineural hearing lossRetroauricular painNerve palsyClinical courseComplete resectionMicrosurgical resectionVestibular schwannomaRare lesionsHistopathologic confirmationKnife radiosurgeryGamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study.
Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL, Lee JY, Kano H, Park KJ, Niranjan A, Kondziolka D, Barnett GH, Rush S, Golfinos JG, Lunsford LD. Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. Journal Of Neurosurgery 2013, 119: 446-56. PMID: 23621595, DOI: 10.3171/2013.3.jns12766.Peer-Reviewed Original ResearchConceptsPrior radiation therapyPituitary adenomasTumor controlNonfunctional pituitary adenomasNerve dysfunctionRadiation therapyNorth American Gamma Knife ConsortiumActuarial tumor controlDegree of hypopituitarismMulticenter patient populationTime of radiosurgeryCranial nerve deficitsPercent of patientsCranial nerve functionOptic nerve dysfunctionCranial nerve dysfunctionGamma Knife surgeryManagement of patientsOverall tumor controlGamma knife radiosurgeryExternal beam radiotherapyProgressive cranial nerve deficitsCommon intracranial neoplasmsDelayed hypopituitarismMargin doses
2011
Delayed Radiation-Induced Vasculitic Leukoencephalopathy
Rauch PJ, Park HS, Knisely JP, Chiang VL, Vortmeyer AO. Delayed Radiation-Induced Vasculitic Leukoencephalopathy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 369-375. PMID: 22024206, DOI: 10.1016/j.ijrobp.2011.06.1982.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryKnife radiosurgeryRadiation therapyYale-New Haven HospitalRadiation-induced leukoencephalopathyHigh-dose radiation fieldT cell infiltrationMetastatic brain cancerFocused radiation therapyMedium-sized vesselsNew Haven HospitalActive vasculitisLeukoencephalopathic changesVasculitic componentBrain metastasesVascular sclerosisNeuropathologic examinationSignificant morbiditySurgical managementTumor recurrencePathological evidenceHistopathologic observationsLeukoencephalopathyPathological differencesBrain cancerImplications of Identifying Additional Cerebral Metastases during Gamma Knife Radiosurgery
Patel TR, Ozturk AK, Knisely JP, Chiang VL. Implications of Identifying Additional Cerebral Metastases during Gamma Knife Radiosurgery. International Journal Of Surgical Oncology 2011, 2012: 748284. PMID: 22312543, PMCID: PMC3265271, DOI: 10.1155/2012/748284.Peer-Reviewed Original ResearchMagnetic resonance imagingNumber of metastasesAdditional metastasesGamma knife radiosurgeryGK-SRSCerebral metastasesAdditional lesionsKnife radiosurgeryProgressive systemic diseaseTreatment magnetic resonance imagingKaplan-Meier analysisImportant prognostic informationMedian survivalRetrospective reviewIntracranial metastasesSystemic diseasePrognostic informationMetastasisPatientsResonance imagingLesionsRadiosurgeryMonthsDaysDisease
2010
Biochemical and clinical responses after treatment of a catecholamine‐secreting glomus jugulare tumor with gamma knife radiosurgery
Castrucci WA, Chiang VL, Hulinsky I, Knisely JP. Biochemical and clinical responses after treatment of a catecholamine‐secreting glomus jugulare tumor with gamma knife radiosurgery. Head & Neck 2010, 32: 1720-1727. PMID: 19787788, DOI: 10.1002/hed.21242.Peer-Reviewed Original ResearchConceptsGlomus jugulare tumorsGamma knife radiosurgeryJugulare tumorsKnife radiosurgeryFunctional capacitySingle-fraction gamma knife radiosurgeryTumor growthMinimal treatment-related morbidityPrimary radiation therapyTreatment-related morbiditySignificant symptomatic improvementLocal tumor growthCatecholamine blockadeHypertensive crisisSymptomatic improvementClinical responseCatecholamine levelsPharmacologic blockadeRadiation therapyDurable controlRadiosurgeryBlockadeTumorsTreatmentMorbidity