Single versus Multifraction Stereotactic Radiosurgery for Large Brain Metastases: An International Meta-analysis of 24 Trials
Lehrer EJ, Peterson JL, Zaorsky NG, Brown PD, Sahgal A, Chiang VL, Chao ST, Sheehan JP, Trifiletti DM. Single versus Multifraction Stereotactic Radiosurgery for Large Brain Metastases: An International Meta-analysis of 24 Trials. International Journal Of Radiation Oncology • Biology • Physics 2018, 103: 618-630. PMID: 30395902, DOI: 10.1016/j.ijrobp.2018.10.038.Peer-Reviewed Original ResearchConceptsLarge brain metastasesMF-SRSSF-SRSMultifraction stereotactic radiosurgeryBrain metastasesRandom effects estimatesStereotactic radiosurgeryLocal controlMeta-AnalysisEffect estimatesRates of radionecrosisProspective clinical trialsPreferred Reporting ItemsRadionecrosis ratePostoperative settingTumor sizeInternational Meta-AnalysisEpidemiology guidelinesClinical trialsObservational studyRandom effectsTumor volumeSummary estimatesReporting ItemsMetastasis