2020
Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure A U.S. Center’s Experience
Griffin M, Soufer A, Goljo E, Colna M, Rao VS, Jeon S, Raghavendra P, D'Ambrosi J, Riello R, Coca SG, Mahoney D, Jacoby D, Ahmad T, Chen M, Tang WHW, Turner J, Mullens W, Wilson FP, Testani JM. Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure A U.S. Center’s Experience. JACC Heart Failure 2020, 8: 199-208. PMID: 32035891, PMCID: PMC7814403, DOI: 10.1016/j.jchf.2019.10.012.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureHypertonic saline administrationHypertonic saline therapyHypertonic salineSaline administrationSaline therapyDiuretic efficiencyUrine outputSerum sodiumWeight lossAcute decompensated heartDecompensated heart failureCohort of patientsTotal urine outputReal-world safetyU.S. academic medical centersAcademic medical centerLarge U.S. academic medical centerDiuretic doseCenter experienceHeart failureMetabolic derangementsPrimary analytic approachRespiratory statusClinical variables
2019
First in Human Experience with Direct Sodium Removal Using a Zero Sodium Peritoneal Solution
Rao V, Turner J, Mahoney D, Griffin M, Asher J, Ivey-Miranda J, Gomez N, Finkelstein F, Testani J. First in Human Experience with Direct Sodium Removal Using a Zero Sodium Peritoneal Solution. Journal Of Cardiac Failure 2019, 25: s7-s8. DOI: 10.1016/j.cardfail.2019.07.027.Peer-Reviewed Original ResearchStandard PD solutionHeart failurePeritoneal dialysisPD solutionsSignificant discomfortPeritoneal solutionsSodium removalHF animal modelsMethods 10 patientsSafety/tolerabilitySecondary efficacy endpointsPrimary endpointEfficacy endpointAdverse eventsBlood pressureSerum sodiumAlternative therapiesPeritoneal fluidPlasma glucosePlasma potassiumUltrafiltration volumeAnimal modelsIntraperitoneal volumeDSR groupVital signs
2018
Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience
Goljo E, Soufer A, Colna M, Rao V, D'Ambrosi J, Riello R, Mahoney D, Tang W, Testani J. Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience. Journal Of Cardiac Failure 2018, 24: s32. DOI: 10.1016/j.cardfail.2018.07.093.Peer-Reviewed Original ResearchAcute decompensated heart failureHypertonic saline solutionDecompensated heart failureHSS administrationHeart failureSerum sodiumHypertonic salineTreatment responseSetting of ADHFHigh-dose loop diureticsMethods Electronic medical recordsLarge urban academic hospitalInotropes/vasopressorsReal-world safetySerum sodium concentrationUrban academic hospitalPotential therapeutic effectsNet fluid outputPositive treatment responseAdditional rigorous studiesElectronic medical recordsImprovement of creatinineADHF patientsFurosemide equivalentsCenter experienceDevelopment of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution
Mahoney D, Rao V, Asher J, Struyk G, Boutagy N, Feher A, Turner J, Sinusas A, Testani J. Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution. Journal Of Cardiac Failure 2018, 24: s34. DOI: 10.1016/j.cardfail.2018.07.099.Peer-Reviewed Original ResearchPeritoneal dialysisIntraperitoneal volumeHeart failureHour dwellFluid removalPlasma volumeNon-renal routesPeritoneal fluid samplesSodium removalMinutes dwell timeSolute dragIndicator dilution techniquePD catheterSerial plasmaSerum sodiumArterial accessDwell timeFluid instillationAnesthetized pigsRemoval solutionPeritoneal solutionsSurgical implantationGrams of sodiumFluid volumeLonger dwell times