Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1
Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip S, Bassi M, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol R, Yen T, Bagella L, Bellacosa A. Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. DNA Repair 2019, 82: 102687. PMID: 31476572, PMCID: PMC6785017, DOI: 10.1016/j.dnarep.2019.102687.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBinding SitesDNA DamageDNA RepairEndodeoxyribonucleasesHEK293 CellsHumansMCF-7 CellsMutationNeoplasmsSUMO-1 ProteinSumoylationConceptsTandem affinity purificationDNA damage responseSumoylation sitesDamage responseDNA mismatch repair protein MLH1Mismatch repair protein MLH1Main SUMOylation siteCalmodulin affinity columnTranscriptional regulationHEK-293 cellsGenomic stabilityNovel proteinCancer Genome AtlasGlycosylase activitySUMOylationProtein MLH1Affinity purificationMBD4CpG sitesU mismatchesUnmodified speciesRepair activityMissense mutationsGenome AtlasHEK-293