2015
Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair
Scanlon V, Soung do Y, Adapala NS, Morgan E, Hansen MF, Drissi H, Sanjay A. Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair. PLOS ONE 2015, 10: e0138194. PMID: 26393915, PMCID: PMC4578922, DOI: 10.1371/journal.pone.0138194.Peer-Reviewed Original ResearchConceptsCbl-PI3K interactionHistomorphometric analysisFracture callusBone formationMid-diaphyseal femoral fracturePI3KNormal bone homeostasisBony callus formationSoft callus formationHealing femursFemoral fracturesWT miceOsteoclast numberBone resorptionTomography scanMurine modelOsteoblast surfaceFracture healingBone homeostasisBone volumeBone repairSkeletal remodelingMiceBiomechanical testingHigh expression
2014
Loss of Cbl–PI3K interaction in mice prevents significant bone loss following ovariectomy
Adapala NS, Holland D, Scanlon V, Barbe MF, Langdon WY, Tsygankov AY, Lorenzo JA, Sanjay A. Loss of Cbl–PI3K interaction in mice prevents significant bone loss following ovariectomy. Bone 2014, 67: 1-9. PMID: 24994594, PMCID: PMC4149851, DOI: 10.1016/j.bone.2014.06.013.Peer-Reviewed Original ResearchConceptsCbl-PI3K interactionSignificant bone lossBone lossSerum levelsBone resorptionBone remodelingPro-collagen type 1Bone resorbing activityDefective bone resorptionC-terminal telopeptideP1NP levelsSerum CTXResorbing activityL2 vertebraBone volumeOvariectomyTyrosine 737Mice resultsType 1Lumbar vertebraeMiceBone formationOsteoclast migrationBone developmentResorption