2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasidiomycotaDisease Models, AnimalEndothelial CellsHumansInterleukin-6MiceScleroderma, LocalizedSkinConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4
2020
Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle–Dependent Dermal Adipose Expansion
Rivera-Gonzalez GC, Klopot A, Sabin K, Baida G, Horsley V, Budunova I. Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle–Dependent Dermal Adipose Expansion. Journal Of Investigative Dermatology 2020, 140: 1698-1705.e1. PMID: 32032578, PMCID: PMC7398827, DOI: 10.1016/j.jid.2019.12.033.Peer-Reviewed Original ResearchConceptsWhite adipose tissueAdipocyte precursor cellsAdipose tissueProtein kinase B signalingDNA damage response 1Loss of REDD1Precursor cellsProtein kinase BAdipogenic marker expressionKinase B signalingHigher lipid accumulationInguinal subcutaneous white adipose tissueGonadal white adipose tissueInterscapular brown adipose tissueSubcutaneous white adipose tissueWhite adipose tissue expansionNegative regulatorPostnatal day 18Wild-type miceAdipose tissue expansionKinase BRegulated developmentBrown adipose tissueHair growth cycleResponse 1
2016
CD301b+ Macrophages Are Essential for Effective Skin Wound Healing
Shook B, Xiao E, Kumamoto Y, Iwasaki A, Horsley V. CD301b+ Macrophages Are Essential for Effective Skin Wound Healing. Journal Of Investigative Dermatology 2016, 136: 1885-1891. PMID: 27287183, PMCID: PMC5727894, DOI: 10.1016/j.jid.2016.05.107.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalFluorescent Antibody TechniqueLectins, C-TypeMacrophagesMaleMiceMice, Inbred C57BLSensitivity and SpecificitySkinWound HealingConceptsSkin wound healingBarrier functionEssential inflammatory cellsAnti-inflammatory macrophagesWound healingSkin barrier functionSubpopulation of macrophagesEarly regenerative stageMultiple myeloid lineagesInflammatory cellsSyngeneic miceWound healing defectsMyeloid cellsCutaneous repairReparative processesSelective depletionPhenotype switchMacrophagesMyeloid lineageMiceMultiple cell typesHealingCD301bHealing defectsSkin repair
2012
Unravelling hair follicle–adipocyte communication
Schmidt B, Horsley V. Unravelling hair follicle–adipocyte communication. Experimental Dermatology 2012, 21: 827-830. PMID: 23163647, PMCID: PMC3507425, DOI: 10.1111/exd.12001.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAlopeciaAnimalsCell CommunicationDisease Models, AnimalHair FollicleHumansHypertrichosisMiceRegenerationSkin Physiological Phenomena