2017
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. The Journal Of Immunology 2017, 199: 1250-1260. PMID: 28701508, PMCID: PMC5544928, DOI: 10.4049/jimmunol.1600941.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantibodiesAutoimmunityEpithelial CellsForkhead Transcription FactorsGene Expression RegulationKeratin-14Lymphocyte ActivationMiceMice, Inbred C57BLMice, NudePositive Regulatory Domain I-Binding Factor 1Thymus GlandT-LymphocytesT-Lymphocytes, RegulatoryTranscription FactorsConceptsThymic epithelial cellsThymic epithelial functionT cellsSelf-reactive T cellsEpithelial functionRegulatory T cell developmentDevelopment of Foxp3Tissue-specific AgsMouse thymic epithelial cellsRegulatory T cellsMedullary thymic epithelial cellsAnti-nuclear AbsCell type-specific deletionT cell developmentDendritic cellsAutoantibody productionAutoimmune diseasesAutoimmune pathologyNude miceAutoimmunityTEC functionConditional deletionCrucial transcription factorMiceEpithelial cells
2009
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. Journal Of Cell Biology 2009, 185: 439-457. PMID: 19398761, PMCID: PMC2700385, DOI: 10.1083/jcb.200901104.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasement MembraneBlood VesselsCapillariesForkhead Transcription FactorsHeart ValvesLymphatic VesselsMiceMice, KnockoutNFATC Transcription FactorsSkin Physiological PhenomenaConceptsLymphatic vessel maturationGenome-wide mapsVessel maturationLymphatic endothelial cellsTranscription factor NFATc1Blood vessel maturationLymphatic developmentNovel regulatorLymphatic maturationUnsuspected linkFOXC2Control formationLymphatic collecting vesselsBlood vasculatureNFATc1Potential targetMaturationIntense investigationEndothelial cellsLymphatic vesselsLymphatic dysfunctionMorphological characterizationRegulatorEnhancerTherapeutic interventions