2022
Adipocyte plasticity in tissue regeneration, repair, and disease
Horsley V. Adipocyte plasticity in tissue regeneration, repair, and disease. Current Opinion In Genetics & Development 2022, 76: 101968. PMID: 35988318, DOI: 10.1016/j.gde.2022.101968.Peer-Reviewed Original ResearchConceptsMammalian tissue repairTissue repairEssential regulatorAdipocyte plasticityFunction of adipocytesCritical regulatorLipid-filled cellsMultiple tissuesTissue functionRegenerative medicineAdipocytesSkeletal muscleBioactive productsRegulatorMammary glandTherapeutic avenuesFibrotic lesionsEndocrine functionTissue regenerationPlasticityWound healingContractile fibroblastsTissueRepairTumorigenesis
2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair
Shook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Cell Stem Cell 2020, 26: 880-895.e6. PMID: 32302523, PMCID: PMC7853423, DOI: 10.1016/j.stem.2020.03.013.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingDermal adipocytesGenetic lineage tracingMammary gland biologyMature adipocytesGenetic mouse studiesAdipocyte-derived lipidsGenetic experimentsTissue homeostasisRNA sequencingLineage tracingECM-producing myofibroblastsDefective wound healingAdipocyte lipolysisMyofibroblast conversionAdipocyte functionEssential roleLipid releaseAdipocytesFatty acidsMacrophage inflammationInflammatory diseasesMultiple aspectsSkin repairMouse studies
2018
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.Peer-Reviewed Original ResearchConceptsMouse mammary glandMilk-producing epithelial cellsTissue-specific rolesMammary glandAdipose growthLipid dynamicsGenetic tracingPhysiological examplesFunctional implicationsCellular mechanismsAdipocyte hypertrophyMature adipocytesEssential roleVivo analysisTissue functionMammary epitheliumAdipocytesEpithelial cellsAdipocyte precursorsSubsequent involutionMilk lipidsPrimary mechanismMechanismLipidomicsMilk fat productionAnatomical, Physiological, and Functional Diversity of Adipose Tissue
Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metabolism 2018, 27: 68-83. PMID: 29320711, PMCID: PMC6050204, DOI: 10.1016/j.cmet.2017.12.002.Peer-Reviewed Original ResearchConceptsStem cell quiescenceInnate immune barrierNon-traditional functionsFunctional diversityEpithelial stem cell quiescenceMammary glandCell quiescenceOrgan regenerationAdipocyte progenitorsHair folliclesNeighboring cellsMetabolic functionsRange of cancersNovel therapeutic approachesAdipose tissue depotsBacterial invasionAdipocytesProgenitorsAutoimmune disordersImmune barrierTherapeutic approachesClose associationAdipose tissueBone marrowTissue depots
2017
PDGFA regulation of dermal adipocyte stem cells
Rivera-Gonzalez GC, Shook BA, Horsley V. PDGFA regulation of dermal adipocyte stem cells. Stem Cell Investigation 2017, 4: 72-72. PMID: 29057244, PMCID: PMC5639037, DOI: 10.21037/sci.2017.08.03.Peer-Reviewed Original ResearchAdipocyte stem cellsBMP moleculesAdipocyte precursorsHair follicle neogenesisDermal white adipose tissueGrowth activationAntibacterial peptidesStem cellsMature adipocytesExtracellular matrix depositionFollicle neogenesisAdipose tissueFibroblast recruitmentTissue repairCentral roleMatrix depositionWhite adipose tissueSystemic metabolismSkin functionWound healingTissueObesity-related diseasesAdipogenesisRegulationAdipocytes
2016
The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches
Shook B, Rivera Gonzalez G, Ebmeier S, Grisotti G, Zwick R, Horsley V. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches. Annual Review Of Cell And Developmental Biology 2016, 32: 1-23. PMID: 27146311, PMCID: PMC5157158, DOI: 10.1146/annurev-cellbio-111315-125426.Peer-Reviewed Original ResearchConceptsStem cell nicheFunction of WATWhite adipose tissueTissue homeostasisCell nicheMetabolic regulationNovel roleMetabolic physiologyMajor regulatorMature adipocytesImmune tissuesVivo regulationEssential roleRole of adipocytesHomeostasisWhite adipocytesAdipocytesTissue regenerationRegulationEndocrine homeostasisRegenerationTissueNicheRegulatorRole
2015
Origin of fibrosing cells in systemic sclerosis
Ebmeier S, Horsley V. Origin of fibrosing cells in systemic sclerosis. Current Opinion In Rheumatology 2015, 27: 555-562. PMID: 26352735, PMCID: PMC4639394, DOI: 10.1097/bor.0000000000000217.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEndothelial cellsInjury-induced fibrosisEpithelial cellsProgressive fibrosisAutoimmune diseasesTreatment optionsEffective therapyInjury modelFibrosis modelChronic natureAnimal modelsTissue stromaSclerosisCell originFibrosisUnknown originVariety of tissuesCellular originRecent evidenceFibrocytesDiseasePericytesSpecific organsAdipocytes
2014
Defining dermal adipose tissue
Driskell RR, Jahoda CA, Chuong C, Watt FM, Horsley V. Defining dermal adipose tissue. Experimental Dermatology 2014, 23: 629-631. PMID: 24841073, PMCID: PMC4282701, DOI: 10.1111/exd.12450.Peer-Reviewed Original ResearchConceptsDevelopment of adipocytesSubcutaneous adipose tissue developmentHair follicle regenerationAdipose tissue developmentDermal adipose tissueTissue developmentEpidermal homeostasisLipid-filled cellsFollicle regenerationCommon precursorRole of adipocytesAdipocytesAdipose tissueDermal fibroblastsDermal white adipose tissueWhite adipose tissueHair folliclesSubcutaneous adiposeInvertebratesCellsTissueRecent dataSpeciesHomeostasisHypodermisCharacterization of Cre recombinase models for the study of adipose tissue
Jeffery E, Berry R, Church CD, Yu S, Shook BA, Horsley V, Rosen ED, Rodeheffer MS. Characterization of Cre recombinase models for the study of adipose tissue. Adipocyte 2014, 3: 206-211. PMID: 25068087, PMCID: PMC4110097, DOI: 10.4161/adip.29674.Peer-Reviewed Original ResearchAdipose tissueAdipocyte precursor cellsAdipose depotsMajor adipose tissue depotsPrecursor cellsWhite adipose depotsAdipose tissue depotsMajor adipose depotsGenetic mouse modelsCre recombinase activityMouse modelTissue depotsCre linesMultiple cell populationsAdipocytesCell populationsDual fluorescent reporterTissueAdipocytes in Skin Health and Disease
Rivera-Gonzalez G, Shook B, Horsley V. Adipocytes in Skin Health and Disease. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015271. PMID: 24591537, PMCID: PMC3935392, DOI: 10.1101/cshperspect.a015271.Peer-Reviewed Original ResearchConceptsCutaneous biologyDermal adipocytesHair follicle growthTissue homeostasisDermal adipose tissueCellular basisRole of adipocytesAdipocytesHair cycleRegenerative capacityBiologyClinical manifestationsCutaneous diseaseReservoir of energyDermal compartmentAdipose tissueFollicle growthPotential roleSkin healthRecent studiesStructural supportWound healingDiseaseDynamic changesHomeostasis
2013
Intradermal adipocytes mediate fibroblast recruitment during skin wound healing
Schmidt BA, Horsley V. Intradermal adipocytes mediate fibroblast recruitment during skin wound healing. Development 2013, 140: 1517-1527. PMID: 23482487, PMCID: PMC3596993, DOI: 10.1242/dev.087593.Peer-Reviewed Original Research
2012
Unravelling hair follicle–adipocyte communication
Schmidt B, Horsley V. Unravelling hair follicle–adipocyte communication. Experimental Dermatology 2012, 21: 827-830. PMID: 23163647, PMCID: PMC3507425, DOI: 10.1111/exd.12001.Peer-Reviewed Original Research