2017
PDGFA regulation of dermal adipocyte stem cells
Rivera-Gonzalez GC, Shook BA, Horsley V. PDGFA regulation of dermal adipocyte stem cells. Stem Cell Investigation 2017, 4: 72-72. PMID: 29057244, PMCID: PMC5639037, DOI: 10.21037/sci.2017.08.03.Peer-Reviewed Original ResearchAdipocyte stem cellsBMP moleculesAdipocyte precursorsHair follicle neogenesisDermal white adipose tissueGrowth activationAntibacterial peptidesStem cellsMature adipocytesExtracellular matrix depositionFollicle neogenesisAdipose tissueFibroblast recruitmentTissue repairCentral roleMatrix depositionWhite adipose tissueSystemic metabolismSkin functionWound healingTissueObesity-related diseasesAdipogenesisRegulationAdipocytes
2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAnimalsCD24 AntigenCell ProliferationCell Self RenewalDermisGene Expression ProfilingHyperplasiaMice, Inbred C57BLModels, BiologicalPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaSignal TransductionSkinStem CellsConceptsAdipocyte stem cellsAdipogenic programLipid-filled mature adipocytesStem Cell Self-RenewalCell Self-RenewalDistinct regulatory mechanismsASC proliferationPI3K/Akt2Stem cell populationWhite adipose tissueUnrecognized regulatorSelf-RenewalRegulatory mechanismsGenetic studiesMature adipocytesPDGFA expressionStem cellsCell populationsTissue growthProliferationActive mechanismDifferent WAT depotsHair growthMaintenanceAkt2