2015
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool
Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez DG, Blagoev KB, Haberman AM, Greco V. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature 2015, 522: 94-97. PMID: 25849774, PMCID: PMC4457634, DOI: 10.1038/nature14306.Peer-Reviewed Original Research
2013
Stem cell dynamics in the hair follicle niche
Rompolas P, Greco V. Stem cell dynamics in the hair follicle niche. Seminars In Cell And Developmental Biology 2013, 25: 34-42. PMID: 24361866, PMCID: PMC3988239, DOI: 10.1016/j.semcdb.2013.12.005.Peer-Reviewed Original ResearchConceptsHair follicle nicheStem cellsStem cell behaviorMouse genetic modelsNon-cellular componentsNiche microenvironmentMolecular signalsCell behaviorNicheMammalian skinHair folliclesProcess of regenerationCell dynamicsCell populationsGenetic modelsExtracellular materialCurrent understandingCellular compositionTissue regenerationCellsRegenerationNew hairAppendagesMicroenvironmentFolliclesSpatial organization within a niche as a determinant of stem-cell fate
Rompolas P, Mesa KR, Greco V. Spatial organization within a niche as a determinant of stem-cell fate. Nature 2013, 502: 513-518. PMID: 24097351, PMCID: PMC3895444, DOI: 10.1038/nature12602.Peer-Reviewed Original ResearchConceptsStem cell fateHair follicle nicheStem cell lineagesStem cellsStem cell nicheHair follicle stem cellsStem cell compartmentFollicle stem cellsFate determinationGenetic lineagesDifferentiated fateAdult tissuesNiche locationsMammalian tissuesNicheHair regenerationLineagesSpatial organizationEpithelial cellsFateCellsHair growthRegenerationLive miceTissue
2012
Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration
Rompolas P, Deschene ER, Zito G, Gonzalez DG, Saotome I, Haberman AM, Greco V. Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Nature 2012, 487: 496-499. PMID: 22763436, PMCID: PMC3772651, DOI: 10.1038/nature11218.Peer-Reviewed Original Research
2010
Compartmentalized organization: a common and required feature of stem cell niches?
Greco V, Guo S. Compartmentalized organization: a common and required feature of stem cell niches? Development 2010, 137: 1586-1594. PMID: 20430743, PMCID: PMC2860245, DOI: 10.1242/dev.041103.Peer-Reviewed Original ResearchConceptsStem cell nicheCell nicheHair follicle stem cell nicheFollicle stem cell nicheAdult stem cell nichesStem cellsStem cell fieldOrgan growthNicheHair regenerationSlow cyclingRecent findingsCell fieldNew growthTissue regenerationRecent studiesCellsGrowthLong-term growthRegenerationProgenyCompartmentsKey questions
2009
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, dela Cruz-Racelis J, Fuchs E. A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration. Cell Stem Cell 2009, 4: 155-169. PMID: 19200804, PMCID: PMC2668200, DOI: 10.1016/j.stem.2008.12.009.Peer-Reviewed Original ResearchConceptsBMP inhibitorsHair germHG cellsStem cellsStem cell activationHair regenerationTransit-amplifying cellsBulge stem cellsDermal papillaCyclic boutsTranscriptional profilingElevated FGFPrecocious activityHair folliclesBulge cellsLate telogenWntCell clustersCell activationCellsTwo-step mechanismSmall cell clustersInitial stepRegenerationInhibitors