2022
Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico
Paz-Bailey G, Sánchez-González L, Torres-Velasquez B, Jones E, Perez-Padilla J, Sharp T, Lorenzi O, Delorey M, Munoz-Jordan J, Tomashek K, Waterman S, Alvarado L, Rivera-Amill V. Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico. The Journal Of Infectious Diseases 2022, 226: 1949-1958. PMID: 35510941, PMCID: PMC10015274, DOI: 10.1093/infdis/jiac165.Peer-Reviewed Original ResearchConceptsSevere plasma leakageSevere dengueReverse transcriptase-polymerase chain reactionPlasma leakageSevere bleedingDengue virusHistory of feverDays of presentationTranscriptase-polymerase chain reactionYear oldsNonsevere dengueOrgan involvementCommon presentationPediatric patientsClinical manifestationsDengue patientsEmergency departmentLaboratory findingsIgM enzymePatientsSerum samplesImmunosorbent assayDengueChain reactionBleeding
2021
Early Release - Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines - Volume 27, Number 12—December 2021 - Emerging Infectious Diseases journal - CDC
Adams C, Jadi R, Segovia-Chumbez B, Daag J, Ylade M, Medina F, Sharp T, Munoz-Jordan J, Yoon I, Deen J, Lopez A, de Silva A, Premkumar L. Early Release - Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines - Volume 27, Number 12—December 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 3073-3081. PMID: 34808091, PMCID: PMC8632176, DOI: 10.3201/eid2712.211150.Peer-Reviewed Original ResearchConceptsZIKV seroprevalenceDENV transmissionEnvelope domain IIIZika virusSerologic assaysInfectious Diseases journal - CDCType-specific antibodiesDengue virus serotypesYears of agePublic health laboratoriesRelated flavivirusesHealth laboratoriesFlaviviridae familySeroprevalenceChildren 9Virus serotypesDomain IIIVirusAntibodiesAssaysDENVFlavivirusesKnowledge gaps in the epidemiology of severe dengue impede vaccine evaluation
Sharp T, Anderson K, Katzelnick L, Clapham H, Johansson M, Morrison A, Harris E, Paz-Bailey G, Waterman S. Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation. The Lancet Infectious Diseases 2021, 22: e42-e51. PMID: 34265259, PMCID: PMC11379041, DOI: 10.1016/s1473-3099(20)30871-9.Peer-Reviewed Original ResearchConceptsDengue virus infectionSevere dengueVirus infectionDisease severityAnti-dengue virus antibodiesMajor organ failureHospital admissionOrgan failureVaccine evaluationClinical spectrumVaccine trialsPrevious infectionRisk factorsVirus antibodiesClinical studiesClinical practiceDengue virusStudy participantsInfectionLack of specificityHost factorsVirus characteristicsDengueEpidemiologyRange of agesFatal Dengue Acquired in Florida
Sharp T, Morris S, Morrison A, de Lima Corvino D, Santiago G, Shieh W, Rico E, Kopp E, Muñoz-Jordán J, Marttos A, Paz-Bailey G, Abbo L, Stanek D. Fatal Dengue Acquired in Florida. New England Journal Of Medicine 2021, 384: 2257-2259. PMID: 34107186, PMCID: PMC11304554, DOI: 10.1056/nejmc2023298.Peer-Reviewed Original ResearchDengue Virus Infections among Peace Corps Volunteers in Timor-Leste, 2018–2019
Sánchez-González L, Venuto M, Poe S, Major C, Baskara L, Abdiyeva S, Murphy D, Munoz-Jordan J, Medina F, Paz-Bailey G, Petersen K, Becker K, Sharp T. Dengue Virus Infections among Peace Corps Volunteers in Timor-Leste, 2018–2019. American Journal Of Tropical Medicine And Hygiene 2021, 104: 2202-2209. PMID: 33901000, PMCID: PMC8176509, DOI: 10.4269/ajtmh.21-0020.Peer-Reviewed Original ResearchConceptsDengue virus infectionMosquito avoidance behaviorsVirus infectionPeace Corps volunteersAnti-DENV IgM antibodiesPeace Corps Medical OfficersOngoing health risksReporting feverDENV infectionIgM antibodiesRecent infectionEpidemiological characteristicsClinical managementMedical recordsMosquito bitesBed netsCollected bloodHealth servicesTravel historyDisease severityDisease controlInfectionMedical officersPreventive measuresDengue
2020
Notes from the Field: Interpretation of Rapid Diagnostic Tests for Leptospirosis During a Dengue Outbreak — Yap State, Federated States of Micronesia, 2019
Dawson P, Marfel M, Galloway R, Tareg A, Paz-Bailey G, Muñoz-Jordán J, Sharp T, Adams L, Bower W. Notes from the Field: Interpretation of Rapid Diagnostic Tests for Leptospirosis During a Dengue Outbreak — Yap State, Federated States of Micronesia, 2019. MMWR Morbidity And Mortality Weekly Report 2020, 69: 1832-1833. PMID: 33270615, PMCID: PMC7714033, DOI: 10.15585/mmwr.mm6948a6.Peer-Reviewed Original ResearchLaboratory-Acquired Dengue Virus Infection, United States, 2018 - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC
Sharp T, Fisher T, Long K, Coulson G, Medina F, Herzig C, Koza M, Muñoz-Jordán J, Paz-Bailey G, Moore Z, Williams C. Laboratory-Acquired Dengue Virus Infection, United States, 2018 - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 1534-1537. PMID: 32568040, PMCID: PMC7323529, DOI: 10.3201/eid2607.191598.Peer-Reviewed Original ResearchReverse Transcription-Polymerase Chain Reaction Testing on Filter Paper-Dried Serum for Laboratory-Based Dengue Surveillance-American Samoa, 2018.
Curren E, Tufa A, Hancock W, Biggerstaff B, Vaifanua-Leo J, Montalbo C, Sharp T, Fischer M, Hills S, Gould C. Reverse Transcription-Polymerase Chain Reaction Testing on Filter Paper-Dried Serum for Laboratory-Based Dengue Surveillance-American Samoa, 2018. American Journal Of Tropical Medicine And Hygiene 2020, 102: 622-624. PMID: 31933466, PMCID: PMC7056409, DOI: 10.4269/ajtmh.19-0800.Peer-Reviewed Original ResearchConceptsReal-time reverse transcription-polymerase chain reactionResource-limited settingsTranscription polymerase chain reaction testingArboviral diseasesReverse transcription-polymerase chain reactionLaboratory-based surveillanceTranscription-polymerase chain reactionDengue virus RNADENV RNAReaction testingDiagnostic testingDengue surveillanceReference laboratorySerumSurveillance of dengueVirus RNAChain reactionDiseaseSurveillanceDengueTravel-Associated and Locally Acquired Dengue Cases — United States, 2010–2017
Rivera A, Adams L, Sharp T, Lehman J, Waterman S, Paz-Bailey G. Travel-Associated and Locally Acquired Dengue Cases — United States, 2010–2017. MMWR Morbidity And Mortality Weekly Report 2020, 69: 149-154. PMID: 32053577, PMCID: PMC7017959, DOI: 10.15585/mmwr.mm6906a1.Peer-Reviewed Original ResearchConceptsReverse transcription-polymerase chain reactionDengue casesDENV nonstructural protein 1 (NS1) antigenNonstructural protein 1 antigenMosquito-transmitted dengue virusAcute febrile illnessIgM positive casesAnti-DENV antibodiesTranscription-polymerase chain reactionProbable dengue casesCompetent mosquito vectorsFebrile illnessMedian ageDENV infectionFatal casesDENV antigenEpidemiologic trendsTravel-associatedDengue virusFamily FlaviviridaeVirus RNADistrict of ColumbiaChain reactionMosquito vectorsAntigen
2013
Dengue outbreak--Federated States of Micronesia, 2012-2013.
Taulung L, Masao C, Palik H, Samo M, Barrow L, Pretrick M, Nilles E, Kool J, Aure F, Simmons R, Moore F, Pyke A, Taylor C, Cao-Lormeau V, Sharp T, Chen T. Dengue outbreak--Federated States of Micronesia, 2012-2013. MMWR Morbidity And Mortality Weekly Report 2013, 62: 570-3. PMID: 23863704, PMCID: PMC4604812.Peer-Reviewed Original ResearchConceptsRapid diagnostic testsNonstructural protein 1World Health OrganizationHealth servicesDengue virus nonstructural protein 1Dengue outbreakHospital surge capacityVirus nonstructural protein 1Resource-limited settingsPublic health activitiesPublic health servicesOutbreak response plansMuscle painClinical managementImmunoglobulin MEnhanced surveillanceEpidemiologic surveillanceSurge capacityHealth consequencesDiagnostic testsHealth activitiesHealth OrganizationProtein 1Laboratory servicesDengueVirus-Specific Differences in Rates of Disease during the 2010 Dengue Epidemic in Puerto Rico
Sharp TM, Hunsperger E, Santiago GA, Muñoz-Jordan JL, Santiago LM, Rivera A, Rodríguez-Acosta RL, Feliciano L, Margolis HS, Tomashek KM. Virus-Specific Differences in Rates of Disease during the 2010 Dengue Epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2013, 7: e2159. PMID: 23593526, PMCID: PMC3617145, DOI: 10.1371/journal.pntd.0002159.Peer-Reviewed Original ResearchConceptsAcute febrile illnessReverse transcriptase-polymerase chain reactionLaboratory-positive casesPrimary infectionDengue casesDENV-1DENV-2Anti-DENV IgM antibodiesSerum specimenMortality of dengueMosquito-transmitted dengue virusPrimary DENV infectionPassive dengue surveillance systemHealth care providersPrimary prevention interventionsTranscriptase-polymerase chain reactionOnly age groupDENV nucleic acidLaboratory diagnostic dataRates of diseaseFebrile illnessSevere dengueDENV infectionIgM antibodiesDENV antigen