Clinical Characteristics, Histopathology, and Tissue Immunolocalization of Chikungunya Virus Antigen in Fatal Cases
Sharp T, Keating M, Shieh W, Bhatnagar J, Bollweg B, Levine R, Blau D, Torres J, Rivera A, Perez-Padilla J, Munoz-Jordan J, Sanabria D, Fischer M, Garcia B, Tomashek K, Zaki S. Clinical Characteristics, Histopathology, and Tissue Immunolocalization of Chikungunya Virus Antigen in Fatal Cases. Clinical Infectious Diseases 2020, 73: e345-e354. PMID: 32615591, PMCID: PMC11307670, DOI: 10.1093/cid/ciaa837.Peer-Reviewed Original ResearchMeSH KeywordsChikungunya FeverChikungunya virusComorbidityDiabetes MellitusHumansMaleMiddle AgedPuerto RicoConceptsSeptic shockFatal casesTissue specimensMononuclear cellsSplenic follicular dendritic cellsChikungunya virus antigenIntra-alveolar hemorrhageFatal septic shockFollicular dendritic cellsChikungunya virus infectionCommon histopathologic findingsBlood mononuclear cellsReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionCHIKV antigenSevere comorbiditiesAcute illnessClinical characteristicsCHIKV infectionDendritic cellsMedian ageRecord reviewIllness onsetImmunohistochemical findingsHistopathologic findings