Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico
Ellis E, Pérez-Padilla J, González L, Lebo E, Baker C, Sharp T, Ochoa E, Díaz-Pinto H, Clavell L, Puig-Ramos A, Berzares E, Lupiañez-Merly C, Garcia H, Janka G, Margolis H, Tomashek K. Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico. Blood 2013, 122: 3497. DOI: 10.1182/blood.v122.21.3497.3497.Peer-Reviewed Original ResearchEpstein-Barr virusHemophagocytic lymphohistiocytosisHLH casesDengue virusCause of HLHIncidence of HLHSystemic onset juvenile arthritisAcute febrile illnessAverage annual incidenceSevere dengue casesCase-control studyHerpes simplex virusDengue-endemic areasEnzyme Linked Immunosorbent AssayDENV type 1Linked Immunosorbent AssayDengue BranchFebrile illnessSevere dengueAnnual incidenceClinical outcomesDENV infectionHematologic syndromeHLH criteriaMild fever