2009
Functional expression of the olfactory signaling system in the kidney
Pluznick JL, Zou DJ, Zhang X, Yan Q, Rodriguez-Gil DJ, Eisner C, Wells E, Greer CA, Wang T, Firestein S, Schnermann J, Caplan MJ. Functional expression of the olfactory signaling system in the kidney. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 2059-2064. PMID: 19174512, PMCID: PMC2644163, DOI: 10.1073/pnas.0812859106.Peer-Reviewed Original ResearchConceptsGlomerular filtration ratePlasma renin levelsMacula densa cellsCOX-2 expressionRenal distal nephronOlfactory G-proteinMDS cell linesOlfactory receptorsRenin levelsRenin secretionFiltration rateNNOS activityTubuloglomerular feedbackDistal nephronOlfactory epitheliumRenal tubulesGFR regulationAdenylate cyclaseG proteinsCell linesSensory roleKidneyFunctional expressionOlfactionExpression
2008
The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate
Pluznick J, Zou D, Zhang X, Yan Q, Rodriguez‐Gil D, Eisner C, Wells E, Greer C, Schnermann J, Wang T, Firestein S, Caplan M. The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate. The FASEB Journal 2008, 22: 761.12-761.12. DOI: 10.1096/fasebj.22.1_supplement.761.12.Peer-Reviewed Original ResearchGlomerular filtration rateMacula densaTubuloglomerular feedbackFiltration rateEfferent arteriolar diametersRT-PCRPlasma renin concentrationRenal function studiesAdenylyl cyclaseWild-type littermatesOlfactory G-proteinOlfactory receptorsRenin concentrationRenin secretionArteriolar diameterOlfactory adenylyl cyclaseWestern blotMouse kidneyKidneyNon-olfactory tissuesRenal epitheliumG proteinsFunction studiesMiceKey regulator