2000
Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice
Wang T, Inglis F, Kalb R. Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. American Journal Of Physiology. Renal Physiology 2000, 279: f518-f524. PMID: 10966931, DOI: 10.1152/ajprenal.2000.279.3.f518.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsBicarbonatesBiological TransportBlood Gas AnalysisBody FluidsElectrolytesEnzyme InhibitorsInjections, IntravenousKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitric Oxide Synthase Type IPotassiumSodiumConceptsNNOS knockout miceWild-type miceL-NAMEProximal tubulesMetabolic acidosisAbsorption of fluidDecreased absorption of fluidBlood pressureIncreased mean blood pressureResponse to L-NAMEWild-type control animalsFluid absorptionAdministration of L-NAMEIn situ microperfusionProximal tubule transportNeuronal nitric oxide synthaseLuminal perfusion solutionMean blood pressureRenal clearance techniquesNitric oxide synthaseRates of HCO(3)(-Urinary Na(+HCO3- absorptionRegulation of acid-base balanceTubule transport
1997
Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule
Wang T. Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule. American Journal Of Physiology 1997, 272: f242-f248. PMID: 9124402, DOI: 10.1152/ajprenal.1997.272.2.f242.Peer-Reviewed Original ResearchConceptsKidney proximal tubulesS-nitroso-N-acetylpenicillamineSodium nitroprussideProximal tubulesL-NAMEGuanylate cyclase inhibitor methyleneN(G)-nitro-L-arginine methyl esterBlood pressureNitric oxideNa+ transportStimulatory effect of sodium nitroprussideN(G)-nitro-L-arginineNitric oxide synthase inhibitorCGMP-mediated mechanismAddition of L-NAMEIncreased urine flow rateGlomerular filtration rateEffects of sodium nitroprussideMean blood pressureUrine flow rateEffects of nitric oxideRenal excretion of NaExcretion of NaRenal hemodynamicsEffects of NO