2016
Expression of KCNJ1 (ROMK) in the Gastrointestinal Tract
Han J, Lee S, Ishikawa Y, Guo X, Xu S, Wang T. Expression of KCNJ1 (ROMK) in the Gastrointestinal Tract. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1224.31.Peer-Reviewed Original ResearchROMK expressionDistal colonMRNA expressionKO miceRenal outer medullary potassium channelEpithelial cellsGI tractGastric acid secretionGastrointestinal (GI) tractHK intakeROMK channelsWT miceDistal nephronReal-time PCRApical membraneROMKPotassium channelsAcid secretionParietal cellsIF stainingRenal tubulesQ-PCR dataEsophagusDiet animalsGastrointestinal tract
2014
Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1
Vucic E, Alfadda T, MacGregor GG, Dong K, Wang T, Geibel JP. Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflügers Archiv - European Journal Of Physiology 2014, 467: 1457-1468. PMID: 25127675, DOI: 10.1007/s00424-014-1593-0.Peer-Reviewed Original ResearchConceptsGastric parietal cellsPotassium channelsParietal cellsΒ-subunitKir1.1 channelsWild-type miceSecretagogue-stimulated gastric acid secretionApical poleGastric glandsLeak pathwayPotential therapeutic targetKir1.1Proton secretionRegulatory characteristicsKv7.1Therapeutic targetATPaseCell numberParietal cell numberCellsNormal gastric acid secretionSecretionInhibitorsAcid secretionMice