Featured Publications
Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling
Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I. Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling. Nature Communications 2015, 6: 6241. PMID: 25716000, PMCID: PMC4351572, DOI: 10.1038/ncomms7241.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsProliferation of VSMCsArterial remodellingΒ-catenin signalingΒ-cateninComplement C1qBlood pressure elevationEnd-organ damageNovel therapeutic targetSmooth muscle cellsMacrophage depletionImmune cellsPrecise molecular mechanismsTherapeutic targetStructural remodellingMuscle cellsRemodellingHypertensionArteriosclerosisComplement C1ActivationC1qMolecular mechanismsSignalingGene deletion
2015
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression
Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I. Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression. Scientific Reports 2015, 5: 14453. PMID: 26571361, PMCID: PMC4585890, DOI: 10.1038/srep14453.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAgingAngiotensin II Type 1 Receptor BlockersAnimalsAxin ProteinBiphenyl CompoundsCell LineComplement C1qDown-RegulationImmunohistochemistryIrbesartanMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalPAX7 Transcription FactorReceptor, Angiotensin, Type 1RegenerationTetrazolesWnt Signaling PathwayConceptsC1q expressionReceptor blockadeAge-related declineAngiotensin II receptor blockadeAT1 receptor blocker irbesartanAngiotensin II type 1 receptorII type 1 receptorAT1 receptor blockadeFunctional muscle recoveryII receptor blockadeSkeletal muscleReceptor blocker irbesartanType 1 receptorWnt/β-catenin pathwaySkeletal muscle functionWnt/β-catenin signalingMuscle regenerationΒ-catenin pathwayCultured macrophage cellsΒ-catenin signalingAT1 receptorMuscle recoveryM2 polarizationMuscle functionTopical administration