2001
G-Protein Signaling Through Tubby Proteins
Santagata S, Boggon T, Baird C, Gomez C, Zhao J, Shan W, Myszka D, Shapiro L. G-Protein Signaling Through Tubby Proteins. Science 2001, 292: 2041-2050. PMID: 11375483, DOI: 10.1126/science.1061233.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsCell MembraneCell NucleusCells, CulturedCrystallography, X-RayGene Expression RegulationGTP-Binding Protein alpha Subunits, Gq-G11Heterotrimeric GTP-Binding ProteinsHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsIsoenzymesMembrane LipidsMiceModels, BiologicalMolecular Sequence DataNuclear Localization SignalsObesityPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhospholipase C betaPhosphorylationProtein Structure, TertiaryProteinsReceptor, Serotonin, 5-HT2CReceptors, MuscarinicReceptors, SerotoninRecombinant Fusion ProteinsSignal TransductionTranscription FactorsType C PhospholipasesConceptsTubby-like protein 3G protein signalingTubby proteinTubby domainTranscription regulatorsPlasma membranePhospholipase C-betaReceptor-mediated activationHeterotrimeric GTPSignal transductionGene expressionMolecular mechanismsTubbyC betaCarboxyl terminalCell nucleiMaturity-onset obesityProteinX-ray crystallographyProtein 3SignalingRegulatorMembranePhosphatidylinositolTransduction
1999
Implication of Tubby Proteins as Transcription Factors by Structure-Based Functional Analysis
Boggon T, Shan W, Santagata S, Myers S, Shapiro L. Implication of Tubby Proteins as Transcription Factors by Structure-Based Functional Analysis. Science 1999, 286: 2119-2125. PMID: 10591637, DOI: 10.1126/science.286.5447.2119.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlternative SplicingAmino Acid SequenceAnimalsCell LineCell NucleusCrystallography, X-RayDNAEye ProteinsHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsModels, MolecularMolecular Sequence DataProtein ConformationProtein Structure, SecondaryProtein Structure, TertiaryProteinsRecombinant ProteinsSequence AlignmentTranscription FactorsTranscriptional ActivationConceptsTubby-like proteinsTubby proteinTranscription factorsBipartite transcription factorDisease phenotypeMulticellular organismsProtein familyBiochemical functionsBiological functionsFunctional analysisStructural cluesCore domainUnique familyProteinGenetic mutationsTubbyPhenotypeRetinal degenerationFamilyMammalsOrganismsVital roleCrystal structureMutationsBroad range
1997
Partial Improvement of Crystal Quality for Microgravity‐Grown Apocrustacyanin C1
Snell E, Cassetta A, Helliwell J, Boggon T, Chayen N, Weckert E, Hölzer K, Schroer K, Gordon E, Zagalsky P. Partial Improvement of Crystal Quality for Microgravity‐Grown Apocrustacyanin C1. Acta Crystallographica Section D, Structural Biology 1997, 53: 231-239. PMID: 15299925, DOI: 10.1107/s0907444996013996.Peer-Reviewed Original ResearchPartial improvement of crystal quality for microgravity-grown apocrustacyanin C1.
Snell E, Cassetta A, Helliwell J, Boggon T, Chayen N, Weckert E, Holzer K, Schroer K, Gordon E, Zagalsky P. Partial improvement of crystal quality for microgravity-grown apocrustacyanin C1. Acta Crystallographica Section D, Structural Biology 1997, 53: 231-9. PMID: 11540431.Peer-Reviewed Original Research
1996
Trends and Challenges in Experimental Macromolecular Crystallography
Chayen N, Boggon T, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop S, Helliwell J, Nieh Y, Peterson M, Raftery J, Snell E, Hädener A, Niemann A, Siddons D, Stojanoff V, Thompson A, Ursby T, Wulff M. Trends and Challenges in Experimental Macromolecular Crystallography. Quarterly Reviews Of Biophysics 1996, 29: 227-278. PMID: 8968112, DOI: 10.1017/s0033583500005837.Peer-Reviewed Original ResearchConceptsHuman genome sequencing projectGenome sequencing projectsModern drug discoveryStructural molecular biologyPrimary sequencingYeast genomeBiological chemistryStructural chemistrySequencing projectsBiological macromoleculesStructural DatabaseRational designMolecular biologyCognate ligandsDrug discoveryMolecular interactionsEnzyme reactivityMacromolecular crystallographyNovel inhibitorsChemistryNucleic acidsVirus structureFunctional detailsStructural detailsPharmaceutical industry