Phosphoglycerate Mutase 1 Promotes Leukemia Metabolism by Coordinating Glycolysis and Biosynthesis, and Represnts a Therapuetic Target in Leukemia Treatment
Hitosugi T, Zhou L, Fan J, Arellano M, Khoury H, Lee B, Boggon T, Kang S, He C, Chen J. Phosphoglycerate Mutase 1 Promotes Leukemia Metabolism by Coordinating Glycolysis and Biosynthesis, and Represnts a Therapuetic Target in Leukemia Treatment. Blood 2012, 120: 860. DOI: 10.1182/blood.v120.21.860.860.Peer-Reviewed Original ResearchPhosphoglycerate mutase 1Pentose phosphate pathwayHuman leukemia cell linesCell proliferationAnabolic biosynthesisCell metabolismLeukemia cell linesOxidative pentose phosphate pathwayPrimary leukemia cellsLeukemia cellsCancer cellsCell linesGlycolytic enzyme phosphoglycerate mutase 1PGAM1 inhibitorsSmall molecule inhibitorsCo-crystal structureXenograft nude miceInhibits cell proliferationLeukemia cell metabolismBiosynthesis pathwayEnzyme activity levelsHuman leukemia cellsShRNA resultsLoss of TP53Phosphate pathway