2023
Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association
Pana Z, El-Shabrawi M, Sultan M, Murray T, Alam A, Yewale V, Dharmapalan D, Klein J, Haddad J, Thacker N, Pulungan A, Hadjipanayis A. Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association. BMJ Paediatrics Open 2023, 7: e002084. PMID: 37500294, PMCID: PMC10387713, DOI: 10.1136/bmjpo-2023-002084.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChildDrug Resistance, BacterialHumansMicrobial Sensitivity TestsPandemics
2019
The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship Programs
Murray TS, Herbst J. The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship Programs. The Journal Of Law, Medicine & Ethics 2019, 47: 541-554. PMID: 31957576, DOI: 10.1177/1073110519897730.Peer-Reviewed Original ResearchConceptsFecal microbiota transplantMultidrug-resistant organismsAntimicrobial stewardship programsMicrobiota transplantStewardship programsCurrent clinical indicationsPublic health threatPatient colonizationSevere recurrentAntibiotic useClinical indicationsResistant organismsAvailable antibioticsHealth threatTransplantAdditional evidenceTherapyInfectionRecurrent
2016
The Approach to Pseudomonas aeruginosa in Cystic Fibrosis
Talwalkar JS, Murray TS. The Approach to Pseudomonas aeruginosa in Cystic Fibrosis. Clinics In Chest Medicine 2016, 37: 69-81. PMID: 26857769, DOI: 10.1016/j.ccm.2015.10.004.BooksMeSH KeywordsAnti-Bacterial AgentsChronic DiseaseCystic FibrosisGlobal HealthHumansMorbidityPseudomonas aeruginosaPseudomonas InfectionsConceptsCystic fibrosisAcute pulmonary exacerbationsDuration of administrationSpecific patient characteristicsStandard of careSite of carePseudomonas aeruginosaPulmonary exacerbationsAntipseudomonal antibioticsPatient characteristicsTreatment optionsEpidemiologic linkChronic infectionHigh prevalenceTreatment decisionsNew vaccinesEarly identificationAggressive useFibrosisAntibiotic selectionInfectionCareLaboratory methodsAeruginosaExacerbation
2015
The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children
Murray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolCommunity-Acquired InfectionsCross InfectionDrug Resistance, MultipleEscherichia coliEscherichia coli InfectionsGram-Negative Bacterial InfectionsHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPrevalenceConceptsMultidrug-resistant infectionsGram-negative rodsProlonged fecal carriageAntibiotic prescribing practicesPrevious antibiotic useExtended-spectrum β-lactamasesCommon risk factorsThird-generation cephalosporinsDiagnostic toolAppropriate therapyChallenging infectionsPrescribing practicesNeonatal ICULaboratory criteriaNew diagnostic toolsRisk factorsAntibiotic useFecal carriageCommunity transmissionClinical implicationsInfectionCephalosporin resistanceKlebsiella pneumoniaeReporting criteriaΒ-lactamases
2014
ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia.
Somily AM, Habib HA, Absar MM, Arshad MZ, Manneh K, Al Subaie SS, Al Hedaithy MA, Sayyed SB, Shakoor Z, Murray TS. ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia. The Journal Of Infection In Developing Countries 2014, 8: 1129-36. PMID: 25212077, DOI: 10.3855/jidc.4292.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-LactamasesBeta-LactamsChildChild, PreschoolEscherichia coliEscherichia coli InfectionsFemaleHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMaleMicrobial Sensitivity TestsMiddle AgedProspective StudiesSaudi ArabiaTertiary Care CentersYoung AdultConceptsTertiary care hospitalK. pneumoniaeCare hospitalStudy periodClavulanic acidKing Khalid University HospitalDeep wound swabsFrequency of ESBLK. pneumoniae isolatesESBL-producing E. coliExtended-spectrum β-lactamasesSterile body fluidsAnti-microbial susceptibilityESBL-producing isolatesOverall frequency rateE. coli resistanceESBL E. coliWound swabsUniversity HospitalEtest stripsPneumoniae isolatesBlood samplesSuperficial swabsAntibiotic susceptibilityFrequency rateUse of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass Spectrometry
Kulkarni MV, Zurita AN, Pyka JS, Murray TS, Hodsdon ME, Peaper DR. Use of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass Spectrometry. Journal Of Clinical Microbiology 2014, 52: 2500-2505. PMID: 24789180, PMCID: PMC4097713, DOI: 10.1128/jcm.00547-14.Peer-Reviewed Original ResearchExtended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: Does vancomycin play a role?
Somily AM, Alsubaie SS, BinSaeed AA, Torchyan AA, Alzamil FA, Al-Aska AI, Al-Khattaf FS, Khalifa LA, Al-Thawadi SI, Alaidan AA, Al-Ahdal MN, Al-Qahtani AA, Murray TS. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: Does vancomycin play a role? American Journal Of Infection Control 2014, 42: 277-282. PMID: 24581016, DOI: 10.1016/j.ajic.2013.09.028.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitESBL-producing Klebsiella pneumoniaeIntensive care unitIncidence density ratioRisk factorsCare unitΒ-lactamase-producing Klebsiella pneumoniaeExtended-spectrum β-lactamase-producing Klebsiella pneumoniaeKlebsiella pneumoniaeRetrospective cohort studySignificant risk factorsPossible risk factorsExtended-spectrum β-lactamaseCohort studyParenteral feedingMechanical ventilationTeaching hospitalNeonatesKlebsiella speciesUnivariate analyzesPossible predictorsInfectionVancomycinΒ-lactamasePneumoniae
2013
Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS
Peaper DR, Kulkarni MV, Tichy AN, Jarvis M, Murray TS, Hodsdon ME. Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS. Bioanalysis 2013, 5: 147-157. PMID: 23330558, PMCID: PMC5753620, DOI: 10.4155/bio.12.310.Peer-Reviewed Original ResearchConceptsLife-threatening infectionsIll patientsGram-negative rodsDiagnostic testsExpression of carbapenemasesAvailable diagnostic testsRapid diagnostic testsRatios of metabolitesLC-MS/MSCarbapenemase activityHodge testCarbapenem resistanceCarbapenemase productionCarbapenem antibioticsΒ-lactam antibioticsThreshold cutoffDA increaseErtapenem hydrolysisLC-MS/MS methodPatientsClinical laboratoriesAntibioticsLCMS/MSInfectionPhysiological levels
2012
Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline.
Somily AM, Absar MM, Arshad MZ, Al Aska AI, Shakoor ZA, Fatani AJ, Siddiqui YM, Murray TS. Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline. Saudi Medical Journal 2012, 33: 750-5. PMID: 22821309.Peer-Reviewed Original ResearchConceptsA. baumannii strainsA. baumanniiTherapeutic optionsBaumannii strainsMinimum inhibitory concentrationAcinetobacter baumanniiP. aeruginosaMultidrug-resistant Pseudomonas aeruginosaBest therapeutic optionAlternative therapeutic optionMDR A. baumanniiAntimicrobial susceptibility patternsNon-fermenting Gram-negative bacteriaNon-duplicate samplesAntimicrobial agentsPseudomonas aeruginosaSusceptibility patternsE-testBaumanniiColistinTigecyclineAlternative antimicrobial agentsDoripenemCarbapenemsInhibitory concentrationThe Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation
Murray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LE, Bruscia EM. The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation. PLOS ONE 2012, 7: e35499. PMID: 22563385, PMCID: PMC3338523, DOI: 10.1371/journal.pone.0035499.Peer-Reviewed Original ResearchConceptsCORM-2 treatmentP. aeruginosa lung infectionP. aeruginosaAeruginosa lung infectionCORM-2Clinical P. aeruginosaMolecule CORM-2Current antimicrobial agentsChronic infectionLung infectionNew therapiesRelated infectionsNon-mucoid strainsReactive oxygen speciesInfectionNovel therapeutic propertiesTherapeutic propertiesAntimicrobial agentsAdditive effectPseudomonas aeruginosaBiofilm formationOxygen speciesTreatmentAeruginosa
2011
Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut Veterans
Fink SL, Martinello RA, Campbell SM, Murray TS. Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut Veterans. Antimicrobial Agents And Chemotherapy 2011, 56: 582-583. PMID: 22064529, PMCID: PMC3256079, DOI: 10.1128/aac.05024-11.Peer-Reviewed Original ResearchConceptsHeterogeneous vancomycin-intermediate Staphylococcus aureusMethicillin-resistant Staphylococcus aureusHeterogeneous Vancomycin-Intermediate Staphylococcus aureus IsolatesVancomycin-intermediate Staphylococcus aureusLow-prevalence populationsStaphylococcus aureus isolatesStaphylococcus aureusPrevalence populationsRoutine screeningVeterans HospitalLow prevalenceAureus isolatesCurve analysisResistance detectionAureusIsolatesPatientsHospitalPrevalenceEtestMicrobiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 5354-5359. PMID: 21402903, PMCID: PMC3069176, DOI: 10.1073/pnas.1019378108.Peer-Reviewed Original ResearchConceptsInfluenza virus infectionVirus infectionDendritic cellsImmune responseCommensal bacteriaRespiratory influenza virus infectionToll-like receptor ligandsVirus-specific CD4CD8 T cellsT cell primingCommensal microbiota compositionProductive immune responseExpression of mRNADistal injectionLymph nodesImmune impairmentIntact microbiotaIL-1βAntibody responseImmune homeostasisRespiratory mucosaAntibiotic treatmentT cellsInflammasome activationCommensal microbiota
2009
Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection
Lan L, Murray TS, Kazmierczak BI, He C. Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Molecular Microbiology 2009, 75: 76-91. PMID: 19943895, PMCID: PMC2881571, DOI: 10.1111/j.1365-2958.2009.06955.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamsFemaleGene DeletionGene Expression Regulation, BacterialGlutathione PeroxidaseHydrogen PeroxideMiceMice, Inbred C57BLModels, BiologicalMutagenesis, Site-DirectedOxidative StressPigments, BiologicalPneumoniaPseudomonas aeruginosaPseudomonas InfectionsQuorum SensingRepressor ProteinsSignal TransductionStress, PhysiologicalTyrosineVirulenceConceptsOxidative stress sensingCys-24Stress sensingPigment productionNull mutant strainOxidative stressSerine substitution mutantsGlobal regulatorPromoter DNASubstitution mutantsAdditional genesInside hostsQuorum sensingCys residuesMutant strainConstitutive expressionMultiple pathwaysRegulatory effectsBeta-lactam resistanceGenesSignificant inductionRegulatorTyrosine metabolismOSPRP. aeruginosa
2007
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
Murray TS, Egan M, Kazmierczak BI. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Current Opinion In Pediatrics 2007, 19: 83-88. PMID: 17224667, DOI: 10.1097/mop.0b013e3280123a5d.Peer-Reviewed Original ResearchConceptsCystic fibrosis patientsChronic colonizationAcute infectionFibrosis patientsCystic fibrosisP. aeruginosaChronic pulmonary colonizationChronic pulmonary diseaseCystic fibrosis airwayHost immune systemMucoid P. aeruginosaP. aeruginosa behaviorCystic fibrosis lungPulmonary diseaseClinical benefitChronic infectionP. aeruginosa pathogenesisLeading causePulmonary colonizationNew therapiesImmune systemAggressive usePotential therapeuticsInfectionPatients