2023
Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association
Pana Z, El-Shabrawi M, Sultan M, Murray T, Alam A, Yewale V, Dharmapalan D, Klein J, Haddad J, Thacker N, Pulungan A, Hadjipanayis A. Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association. BMJ Paediatrics Open 2023, 7: e002084. PMID: 37500294, PMCID: PMC10387713, DOI: 10.1136/bmjpo-2023-002084.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChildDrug Resistance, BacterialHumansMicrobial Sensitivity TestsPandemics
2015
The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children
Murray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolCommunity-Acquired InfectionsCross InfectionDrug Resistance, MultipleEscherichia coliEscherichia coli InfectionsGram-Negative Bacterial InfectionsHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPrevalenceConceptsMultidrug-resistant infectionsGram-negative rodsProlonged fecal carriageAntibiotic prescribing practicesPrevious antibiotic useExtended-spectrum β-lactamasesCommon risk factorsThird-generation cephalosporinsDiagnostic toolAppropriate therapyChallenging infectionsPrescribing practicesNeonatal ICULaboratory criteriaNew diagnostic toolsRisk factorsAntibiotic useFecal carriageCommunity transmissionClinical implicationsInfectionCephalosporin resistanceKlebsiella pneumoniaeReporting criteriaΒ-lactamases
2014
ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia.
Somily AM, Habib HA, Absar MM, Arshad MZ, Manneh K, Al Subaie SS, Al Hedaithy MA, Sayyed SB, Shakoor Z, Murray TS. ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia. The Journal Of Infection In Developing Countries 2014, 8: 1129-36. PMID: 25212077, DOI: 10.3855/jidc.4292.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-LactamasesBeta-LactamsChildChild, PreschoolEscherichia coliEscherichia coli InfectionsFemaleHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMaleMicrobial Sensitivity TestsMiddle AgedProspective StudiesSaudi ArabiaTertiary Care CentersYoung AdultConceptsTertiary care hospitalK. pneumoniaeCare hospitalStudy periodClavulanic acidKing Khalid University HospitalDeep wound swabsFrequency of ESBLK. pneumoniae isolatesESBL-producing E. coliExtended-spectrum β-lactamasesSterile body fluidsAnti-microbial susceptibilityESBL-producing isolatesOverall frequency rateE. coli resistanceESBL E. coliWound swabsUniversity HospitalEtest stripsPneumoniae isolatesBlood samplesSuperficial swabsAntibiotic susceptibilityFrequency rate
2013
Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS
Peaper DR, Kulkarni MV, Tichy AN, Jarvis M, Murray TS, Hodsdon ME. Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS. Bioanalysis 2013, 5: 147-157. PMID: 23330558, PMCID: PMC5753620, DOI: 10.4155/bio.12.310.Peer-Reviewed Original ResearchConceptsLife-threatening infectionsIll patientsGram-negative rodsDiagnostic testsExpression of carbapenemasesAvailable diagnostic testsRapid diagnostic testsRatios of metabolitesLC-MS/MSCarbapenemase activityHodge testCarbapenem resistanceCarbapenemase productionCarbapenem antibioticsΒ-lactam antibioticsThreshold cutoffDA increaseErtapenem hydrolysisLC-MS/MS methodPatientsClinical laboratoriesAntibioticsLCMS/MSInfectionPhysiological levels
2012
Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline.
Somily AM, Absar MM, Arshad MZ, Al Aska AI, Shakoor ZA, Fatani AJ, Siddiqui YM, Murray TS. Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline. Saudi Medical Journal 2012, 33: 750-5. PMID: 22821309.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAnti-Bacterial AgentsCarbapenemsColistinDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsMinocyclinePseudomonas aeruginosaTigecyclineConceptsA. baumannii strainsA. baumanniiTherapeutic optionsBaumannii strainsMinimum inhibitory concentrationAcinetobacter baumanniiP. aeruginosaMultidrug-resistant Pseudomonas aeruginosaBest therapeutic optionAlternative therapeutic optionMDR A. baumanniiAntimicrobial susceptibility patternsNon-fermenting Gram-negative bacteriaNon-duplicate samplesAntimicrobial agentsPseudomonas aeruginosaSusceptibility patternsE-testBaumanniiColistinTigecyclineAlternative antimicrobial agentsDoripenemCarbapenemsInhibitory concentration
2011
Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut Veterans
Fink SL, Martinello RA, Campbell SM, Murray TS. Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut Veterans. Antimicrobial Agents And Chemotherapy 2011, 56: 582-583. PMID: 22064529, PMCID: PMC3256079, DOI: 10.1128/aac.05024-11.Peer-Reviewed Original ResearchConceptsHeterogeneous vancomycin-intermediate Staphylococcus aureusMethicillin-resistant Staphylococcus aureusHeterogeneous Vancomycin-Intermediate Staphylococcus aureus IsolatesVancomycin-intermediate Staphylococcus aureusLow-prevalence populationsStaphylococcus aureus isolatesStaphylococcus aureusPrevalence populationsRoutine screeningVeterans HospitalLow prevalenceAureus isolatesCurve analysisResistance detectionAureusIsolatesPatientsHospitalPrevalenceEtest