2015
The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children
Murray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolCommunity-Acquired InfectionsCross InfectionDrug Resistance, MultipleEscherichia coliEscherichia coli InfectionsGram-Negative Bacterial InfectionsHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPrevalenceConceptsMultidrug-resistant infectionsGram-negative rodsProlonged fecal carriageAntibiotic prescribing practicesPrevious antibiotic useExtended-spectrum β-lactamasesCommon risk factorsThird-generation cephalosporinsDiagnostic toolAppropriate therapyChallenging infectionsPrescribing practicesNeonatal ICULaboratory criteriaNew diagnostic toolsRisk factorsAntibiotic useFecal carriageCommunity transmissionClinical implicationsInfectionCephalosporin resistanceKlebsiella pneumoniaeReporting criteriaΒ-lactamases
2014
ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia.
Somily AM, Habib HA, Absar MM, Arshad MZ, Manneh K, Al Subaie SS, Al Hedaithy MA, Sayyed SB, Shakoor Z, Murray TS. ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia. The Journal Of Infection In Developing Countries 2014, 8: 1129-36. PMID: 25212077, DOI: 10.3855/jidc.4292.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-LactamasesBeta-LactamsChildChild, PreschoolEscherichia coliEscherichia coli InfectionsFemaleHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMaleMicrobial Sensitivity TestsMiddle AgedProspective StudiesSaudi ArabiaTertiary Care CentersYoung AdultConceptsTertiary care hospitalK. pneumoniaeCare hospitalStudy periodClavulanic acidKing Khalid University HospitalDeep wound swabsFrequency of ESBLK. pneumoniae isolatesESBL-producing E. coliExtended-spectrum β-lactamasesSterile body fluidsAnti-microbial susceptibilityESBL-producing isolatesOverall frequency rateE. coli resistanceESBL E. coliWound swabsUniversity HospitalEtest stripsPneumoniae isolatesBlood samplesSuperficial swabsAntibiotic susceptibilityFrequency rate
2000
Characterization of ywhE, which encodes a putative high-molecular-weight class A penicillin-binding protein in Bacillus subtilis
Pedersen L, Ragkousi K, Cammett T, Melly E, Sekowska A, Schopick E, Murray T, Setlow P. Characterization of ywhE, which encodes a putative high-molecular-weight class A penicillin-binding protein in Bacillus subtilis. Gene 2000, 246: 187-196. PMID: 10767540, DOI: 10.1016/s0378-1119(00)00084-6.Peer-Reviewed Original ResearchAmino Acid SequenceBacillus subtilisBacterial ProteinsBase SequenceCarrier ProteinsCell DivisionEscherichia coliGene Expression Regulation, BacterialHexosyltransferasesLac OperonMolecular Sequence DataMolecular WeightMuramoylpentapeptide CarboxypeptidaseMutagenesis, InsertionalMutationPenicillin-Binding ProteinsPeptidyl TransferasesPromoter Regions, GeneticRecombinant Fusion ProteinsSigma FactorSpores, Bacterial
1998
Characterization of dacC, Which Encodes a New Low-Molecular-Weight Penicillin-Binding Protein in Bacillus subtilis
Pedersen L, Murray T, Popham D, Setlow P. Characterization of dacC, Which Encodes a New Low-Molecular-Weight Penicillin-Binding Protein in Bacillus subtilis. Journal Of Bacteriology 1998, 180: 4967-4973. PMID: 9733705, PMCID: PMC107527, DOI: 10.1128/jb.180.18.4967-4973.1998.Peer-Reviewed Original ResearchConceptsWeight penicillin-binding proteinsPenicillin-binding proteinsBacillus subtilis genome sequencing projectB. subtilis chromosomeGenome sequencing projectsWild-type cellsWild-type sporesInsertional mutantsPenicillin binding proteinsSequencing projectsSequence homologyUnknown functionBacillus subtilisEscherichia coliGenesPBP genesProteinSame heat resistanceOutgrowth kineticsExpressionSigmaHMutantsChromosomesHomologyPromoter