2023
Growing thin — How bulk lipid transport drives expansion of the autophagosome membrane but not of its lumen
Melia T. Growing thin — How bulk lipid transport drives expansion of the autophagosome membrane but not of its lumen. Current Opinion In Cell Biology 2023, 83: 102190. PMID: 37385155, PMCID: PMC10528516, DOI: 10.1016/j.ceb.2023.102190.Peer-Reviewed Original Research
2019
ATG2 transports lipids to promote autophagosome biogenesis
Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. ATG2 transports lipids to promote autophagosome biogenesis. Journal Of Cell Biology 2019, 218: 1787-1798. PMID: 30952800, PMCID: PMC6548141, DOI: 10.1083/jcb.201811139.Peer-Reviewed Original ResearchConceptsProtein-mediated lipid transferLipid transferLipid transfer proteinTransfers lipidsAutophagosome biogenesisAutophagosome membraneDonor membranesN-terminal fragmentDifferent organellesAutophagy proteinsAutophagosome formationKO cellsContact sitesSpecific machineryLipid homeostasisClear functionAtg2BiogenesisProteinDelivery of lipidsLipidsATG2AMembraneOrganellesAutophagosomes