2019
Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A. Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes. Nature Cell Biology 2019, 21: 372-383. PMID: 30778222, PMCID: PMC7032593, DOI: 10.1038/s41556-019-0274-9.Peer-Reviewed Original ResearchConceptsMembrane-binding regionTerminal membrane-binding regionLC3B lipidationMembrane-binding amphipathic helixLC3/GABARAPDifferent cellular conditionsDouble-membrane phagophoreSingle-membrane structuresGABARAP proteinsCanonical autophagyCellular conditionsAmphipathic helixTarget membraneMembrane bindingC-terminusDistinct functionsCovalent modificationLipidationΒ isoformsEssential roleKey eventsIsoformsPhagophoreGABARAPMacroautophagy
2007
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
Shen J, Tareste DC, Paumet F, Rothman JE, Melia TJ. Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins. Cell 2007, 128: 183-195. PMID: 17218264, DOI: 10.1016/j.cell.2006.12.016.Peer-Reviewed Original ResearchConceptsSec1/Munc18 (SM) proteinsMunc18 proteinsSm proteinsIntracellular membrane fusionSNARE fusion machineryCognate SNAREsV-SNAREFusion specificityFusion machineryMunc18-1Membrane fusionMolecular mechanismsStimulatory subunitProteinNeurotransmitter releaseFundamental roleSNAREpinsSelective activationExocytosisSubunitsMachinerySnareFusionActivationBilayers