Binding of viral attachment protein to host-cell receptor: the Achilles heel of infectious viruses
Lentz T. Binding of viral attachment protein to host-cell receptor: the Achilles heel of infectious viruses. Trends In Pharmacological Sciences 1988, 9: 247-252. PMID: 3073564, DOI: 10.1016/0165-6147(88)90154-x.Peer-Reviewed Original ResearchConceptsViral attachment proteinAttachment proteinHost cell receptorsVirus-receptor interactionsViral polypeptidesMolecular levelCellular receptorsProteinResult of bindingAchilles heelProduction of agentsStrain of virusSame receptorReceptorsVirus attachmentInfectious virusTherapeutic agentsVirusPolypeptideRational designSitesBindingSynthetic peptides in the study of the interaction of rabies virus and the acetylcholine receptor.
Lentz T, Hawrot E, Donnelly-Roberts D, Wilson P. Synthetic peptides in the study of the interaction of rabies virus and the acetylcholine receptor. Advances In Biochemical Psychopharmacology 1988, 44: 57-71. PMID: 3041753.Peer-Reviewed Original ResearchConceptsSnake venom neurotoxinsAmino acid sequence similarityCentral nervous systemAcetylcholine receptorsVirus glycoproteinVenom neurotoxinsPeriod of replicationRabies virus glycoproteinRegions of virusesNervous systemGenetic driftSequence similarityVirus-receptor interactionsMolecular basisRabies virusCertain neuronal populationsDirect bindingRNA virusesNicotinic acetylcholine receptorsCell surface constituentsBlood-brain barrierCell receptorGlycoproteinBindingD-tubocurarine