2024
Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}
Wilcox C, Bang J, Buxbaum J, Gardner T, Hawes R, Kedia P, Mardini S, Muniraj T, Navaneethan U, Oza V, Tarnasky P, Thakkar S, Waxman I, Varadarajulu S. Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}. Trials 2024, 25: 676. PMID: 39396987, PMCID: PMC11472533, DOI: 10.1186/s13063-024-08478-y.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAutonomic Nerve BlockCeliac PlexusEndosonographyHumansMulticenter Studies as TopicNerve BlockPain MeasurementPalliative CarePancreatitis, ChronicProspective StudiesRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsCeliac plexus blockAbdominal painChronic pancreatitisVisual analog scalePlexus blockSham-controlled trialRandomized sham-controlled trialEndoscopic ultrasound-guided celiac plexus blockEffectiveness of endoscopic ultrasoundBrief Pain Inventory Short FormDocumented chronic pancreatitisPainful chronic pancreatitisPalliation of painTime of EUSTreatment of abdominal painPain scoresBPI-SFSteroid combinationsAnalog scaleEndoscopic ultrasoundProspective studyCeliac plexusRandomized trialsShort formPancreatitis
2022
Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium
Singh V, Whitcomb D, Banks P, AlKaade S, Anderson M, Amann S, Brand R, Conwell D, Cote G, Gardner T, Gelrud A, Guda N, Forsmark C, Lewis M, Sherman S, Muniraj T, Romagnuolo J, Tan X, Tang G, Sandhu B, Slivka A, Wilcox C, Yadav D, Wilcox C, Guda N, Banks P, Conwell D, Lo S, Gelrud A, Gardner T, Baillie J, Forsmark C, Muniraj T, Sherman S, Singh V, Lewis M, Romagnuolo J, Hawes R, Cote G, Lawrence C, Anderson M, Amann S, Etemad B, DeMeo M, Kochman M, Abberbock J, Barmada M, Bauer E, Brand R, Kennard E, LaRusch J, O'Connell M, Stello K, Slivka A, Talluri J, Tang G, Whitcomb D, Wisniewski S, Yadav D, Burton F, AlKaade S, DiSario J, Sandhu B, Money M, Steinberg W. Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium. Pancreatology 2022, 22: 1091-1098. PMID: 36404201, PMCID: PMC10122210, DOI: 10.1016/j.pan.2022.10.004.Peer-Reviewed Original ResearchConceptsDiagnosis of CPAcute pancreatitisChronic pancreatitisCP diagnosisAP patientsAssociation of APNorth American Pancreatitis StudiesMajority of patientsMultivariable logistic regressionDisease-related factorsNorth American cohortClinical acute pancreatitisAP episodeAbdominal painSecondary preventionMultivariable analysisExocrine insufficiencyPancreatic atrophyMore episodesUS CentersWhite raceLower oddsPatientsAmerican cohortPancreatitis
2019
Perforation of the duodenum 2 weeks after lumen-apposing metal stent placement for malignant pyloric stricture
Muniraj T, Salem R, Olave-Martinez M, Suarez A, Aslanian HR. Perforation of the duodenum 2 weeks after lumen-apposing metal stent placement for malignant pyloric stricture. Gastrointestinal Endoscopy 2019, 89: 1069-1070. PMID: 30639540, DOI: 10.1016/j.gie.2019.01.006.Peer-Reviewed Original Research
2017
Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities
Machicado JD, Amann ST, Anderson MA, Abberbock J, Sherman S, Conwell DL, Cote GA, Singh VK, Lewis MD, Alkaade S, Sandhu BS, Guda NM, Muniraj T, Tang G, Baillie J, Brand RE, Gardner TB, Gelrud A, Forsmark CE, Banks PA, Slivka A, Wilcox CM, Whitcomb DC, Yadav D. Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities. The American Journal Of Gastroenterology 2017, 112: 633. PMID: 28244497, PMCID: PMC5828017, DOI: 10.1038/ajg.2017.42.Peer-Reviewed Original ResearchConceptsQuality of lifeMild-moderate painCurrent smokingChronic pancreatitisMCS scoresConstant painCP patientsSevere painShort Form-12 (SF-12) surveyMental component summary scoresConstant severe painComponent summary scoresMultivariable linear regression modelsAssociated co morbiditiesIndependent effectsFinal multivariable modelNAPS2 studySignificant independent effectDisease durationCo morbiditiesMean PCSIndependent predictorsMultivariable analysisPancreatic surgeryPCS scores
2016
Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis
Wilcox CM, Sandhu BS, Singh V, Gelrud A, Abberbock JN, Sherman S, Cote GA, Al-Kaade S, Anderson MA, Gardner TB, Lewis MD, Forsmark CE, Guda NM, Romagnuolo J, Baillie J, Amann ST, Muniraj T, Tang G, Conwell DL, Banks PA, Brand RE, Slivka A, Whitcomb D, Yadav D. Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis. The American Journal Of Gastroenterology 2016, 111: 1488. PMID: 27527745, PMCID: PMC6196097, DOI: 10.1038/ajg.2016.316.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultAgedAtrophyBlack or African AmericanCalcinosisCommon Bile Duct DiseasesConstriction, PathologicExocrine Pancreatic InsufficiencyFemaleHumansMaleMiddle AgedPain MeasurementPancreasPancreatic DiseasesPancreatic DuctsPancreatitis, AlcoholicPancreatitis, ChronicPrevalenceProspective StudiesRisk FactorsSex FactorsSmokingTime FactorsWhite PeopleYoung AdultConceptsChronic pancreatitisBlack patientsClinical profileDuration of CPNorth American Pancreatitis StudiesDuration of diseaseAlcoholic chronic pancreatitisProgression of pancreatitisRacial differencesPrior cholecystectomyPain characteristicsAlcohol etiologyCurrent smokersDisease durationSevere painEndoscopic treatmentWhite patientsRisk factorsPancreatic morphologyUS CentersEpidemiologic studiesPatientsAdvanced changesRetrospective dataDetailed questionnaire