2003
Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women
Morton L, Holford T, Leaderer B, Boyle P, Zahm S, Zhang Y, Flynn S, Tallini G, Zhang B, Owens P, Zheng T. Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women. British Journal Of Cancer 2003, 89: 2087-2092. PMID: 14647142, PMCID: PMC2376853, DOI: 10.1038/sj.bjc.6601388.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaCumulative lifetime exposureCurrent smoking statusCigarette smokingNHL subtypesFollicular lymphomaLifetime exposurePopulation-based case-control studyRisk of NHLEtiology of NHLNon-Hodgkin lymphoma subtypesDuration of smokingIntensity of smokingPrevious epidemiologic studiesCase-control studyPopulation-based controlsHistologic typeSmoking statusIncident casesTumor gradeLymphoma subtypesEpidemiologic studiesSmokingImmunologic typeLymphoma
2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegression
1996
Maternal Caffeine Consumption and Spontaneous Abortion: A Prospective Cohort Study
Dlugosz L, Belanger K, Hellenbrand K, Holford T, Leaderer B, Bracken M. Maternal Caffeine Consumption and Spontaneous Abortion: A Prospective Cohort Study. Epidemiology 1996, 7: 250-255. PMID: 8728437, DOI: 10.1097/00001648-199605000-00008.Peer-Reviewed Original ResearchConceptsSpontaneous abortionCaffeine consumptionYale-New Haven HospitalMaternal caffeine consumptionProspective cohort studyCohort studyEarly pregnancyPregnant womenOdds ratioSoda drinkingElevated riskCaffeine beveragesBeverage consumptionCaffeine beverage consumptionCigarette useFirst monthPregnancySixteenth weekObserved associationsAbortionCup of teaCaffeineTeaGestationHospitalA MODEL FOR THE EFFECT OF CIGARETTE SMOKING ON LUNG CANCER INCIDENCE IN CONNECTICUT
HOLFORD T, ZHANG Z, ZHENG T, MCKAY L. A MODEL FOR THE EFFECT OF CIGARETTE SMOKING ON LUNG CANCER INCIDENCE IN CONNECTICUT. Statistics In Medicine 1996, 15: 565-580. PMID: 8731001, DOI: 10.1002/(sici)1097-0258(19960330)15:6<565::aid-sim185>3.0.co;2-t.Peer-Reviewed Original ResearchConceptsLung cancer incidenceCancer incidenceIncidence rateLung cancer incidence ratesLung cancer incidence trendsEffect of smokingCancer incidence ratesCancer incidence trendsCohort studyCurrent smokersLevel of exposureMale smokersSmoking historySmoking subgroupsSmoking informationCigarette smokingMean durationSmoking prevalenceIncidence trendsSmokersSmokingPrevalenceCohort effectsAge distributionIncidenceA TREE‐BASED METHOD OF ANALYSIS FOR PROSPECTIVE STUDIES
ZHANG H, HOLFORD T, BRACKEN M. A TREE‐BASED METHOD OF ANALYSIS FOR PROSPECTIVE STUDIES. Statistics In Medicine 1996, 15: 37-49. PMID: 8614744, DOI: 10.1002/(sici)1097-0258(19960115)15:1<37::aid-sim144>3.0.co;2-0.Peer-Reviewed Original Research
1993
The risk of determining risk with multivariable models.
Concato J, Feinstein A, Holford T. The risk of determining risk with multivariable models. Annals Of Internal Medicine 1993, 118: 201-10. PMID: 8417638, DOI: 10.7326/0003-4819-118-3-199302010-00009.Peer-Reviewed Original Research
1988
Patterns of invasive melanoma in the connecticut tumor registry. Is the long‐term increase real?
Roush G, Schymura M, Holford T. Patterns of invasive melanoma in the connecticut tumor registry. Is the long‐term increase real? Cancer 1988, 61: 2586-2595. PMID: 3365679, DOI: 10.1002/1097-0142(19880615)61:12<2586::aid-cncr2820611233>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsConnecticut Tumor RegistryProportion of casesIncidence rateTumor RegistryCase ascertainmentBirth cohortPopulation-based incidence dataInvasive cutaneous malignant melanomaPeriod of diagnosisCutaneous malignant melanomaPatterns of changeMalignant melanomaInvasive melanomaCohort curvesAge groupsDisease riskAnalysis of ageIncidence dataMelanomaRegistryCohortDiagnosisArtifactual changesAscertainmentLong-term increase
1987
Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time
Peduzzi P, Holford T, Detre K, Chan Y. Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time. Journal Of Clinical Epidemiology 1987, 40: 761-767. PMID: 3597677, DOI: 10.1016/0021-9681(87)90127-5.Peer-Reviewed Original Research
1986
Risk of Late First and Second Trimester Miscarriage After Induced Abortion
Bracken M, Bryce-Buchanan C, Srisuphan W, Holford T, Silten R. Risk of Late First and Second Trimester Miscarriage After Induced Abortion. American Journal Of Perinatology 1986, 3: 84-91. PMID: 3964388, DOI: 10.1055/s-2007-999839.Peer-Reviewed Original ResearchConceptsFirst prenatal visitSecond trimester miscarriagePrivate obstetric practicesLate miscarriagePrenatal visitFirst pregnancySecond pregnancySecond trimesterSubsequent miscarriageTrimester miscarriagePregnancy historyObstetric practiceInduced abortionMiscarriagePregnancyWomenAbortionRiskLate FirstTrimesterCohortVisitsLOW BIRTH WEIGHT IN PREGNANCIES FOLLOWING INDUCED ABORTION: NO EVIDENCE FOR AN ASSOCIATION1
BRACKEN M, HELLENBRAND K, HOLFORD T, BRYCE-BUCHANAN C. LOW BIRTH WEIGHT IN PREGNANCIES FOLLOWING INDUCED ABORTION: NO EVIDENCE FOR AN ASSOCIATION1. American Journal Of Epidemiology 1986, 123: 604-613. PMID: 3953539, DOI: 10.1093/oxfordjournals.aje.a114280.Peer-Reviewed Original ResearchConceptsLow birth weightMean birth weightFirst pregnancyBirth weightSecond pregnancyInduced abortionLow birth weight newbornsLow birth weight rateAntecedent pregnancyWeight newbornsSubsequent pregnancyAbortion complicationsVacuum aspirationPrior abortionPregnancyAbortionWeight rateSimilar ratesMonthsWomenDeliveryRiskCurettageComplicationsGestation
1985
Risk Factors for Fibrocystic Breast Disease and Its Histopathologic Components2
Berkowitz G, Kelsey J, LiVolsi V, Holford T, Merino M, Ort S, O'Connor T, White C. Risk Factors for Fibrocystic Breast Disease and Its Histopathologic Components2. Journal Of The National Cancer Institute 1985, 75: 43-50. PMID: 3859695, DOI: 10.1093/jnci/75.1.43.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseBenign breast diseaseBreast diseaseHigher socioeconomic statusOdds ratioLow Quetelet's indexSocioeconomic statusBreast cancer patientsCase-control studyEpidemiologic similaritiesCurrent smokersPostmenopausal womenPremenopausal womenEpithelial atypiaGross cystsFibrocystic diseaseCancer patientsPapillary hyperplasiaQuetelet indexBiopsy specimensRisk factorsSurgical conditionsConnecticut hospitalsLow parityBreast cancerRisk for cutaneous melanoma in recent Connecticut birth cohorts.
Roush G, Schymura M, Holford T. Risk for cutaneous melanoma in recent Connecticut birth cohorts. American Journal Of Public Health 1985, 75: 679-82. PMID: 4003640, PMCID: PMC1646211, DOI: 10.2105/ajph.75.6.679.Peer-Reviewed Original ResearchAN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA
PASTIDES H, KELSEY J, HOLFORD T, LIVOLSI V. AN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA. American Journal Of Epidemiology 1985, 121: 440-447. PMID: 4014134, DOI: 10.1093/oxfordjournals.aje.a114016.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseDuctal epithelial atypiaCase-control studyBreast diseaseDuctal atypiaEpithelial atypiaMinimal atypiaBreast cancerFirst-degree female relativesBreast biopsy specimensRecent checkupSurgical menopauseEpidemiologic characteristicsFirst pregnancyBiopsy specimensRisk factorsEpidemiologic studiesAtypiaCheckupAtypia scoreFrequent checkupsBreast lesionsDiseaseFemale relativesOnly variableESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1
BERKOWITZ G, KELSEY J, HOLFORD T, LIVOLSI V, MERINO M, BECK G, ORT S, O'CONNOR T, WHITE C. ESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1. American Journal Of Epidemiology 1985, 121: 238-245. PMID: 4014118, DOI: 10.1093/oxfordjournals.aje.a113994.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseReplacement therapyPostmenopausal womenHospital-based case-control studyMedical care utilizationPossible risk factorsCase-control studyDuration of useOdds of diseasePostmenopausal women1Care utilizationMenopausal estrogensExcess oddsRisk factorsSurgical conditionsTherapyDiseasePositive associationMore yearsWomenOddsAssociationEstrogenAn alternative approach to statistical age-period-cohort analysis
Holford T. An alternative approach to statistical age-period-cohort analysis. Journal Of Clinical Epidemiology 1985, 38: 831-836. PMID: 4044768, DOI: 10.1016/0021-9681(85)90106-7.Peer-Reviewed Original ResearchMenarcheal age and habitual miscarriage: evidence for an association
Bracken M, Bryce-Buchanan C, Stilten R, Holford T. Menarcheal age and habitual miscarriage: evidence for an association. Annals Of Human Biology 1985, 12: 525-531. PMID: 4091507, DOI: 10.1080/03014468500008101.Peer-Reviewed Original Research
1984
Exogenous hormone use and fibrocystic breast disease by histopathologic component
Berkowitz G, Kelsey J, Livolsi V, Merino M, Holford T, Hildreth N, Ort S, O'Connor T, White C. Exogenous hormone use and fibrocystic breast disease by histopathologic component. International Journal Of Cancer 1984, 34: 443-449. PMID: 6490201, DOI: 10.1002/ijc.2910340403.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseGross cystsReplacement therapyHospital-based case-control studyExogenous hormone useOral contraceptive usePost-menopausal womenCase-control studyPostmenopausal womenPremenopausal womenHormone useOral contraceptivesEpithelial atypiaControl womenPapillary hyperplasiaBiopsy specimensFibrocystic lesionsSurgical conditionsContraceptive useHistopathologic componentsWomenIncreased occurrenceDiseaseAcute Prolapsed Lumbar Intervertebral Disc An Epidemiologic Study with Special Reference to Driving Automobiles and Cigarette Smoking
KELSEY J, GITHENS P, O'CONNER T, WEIL U, CALOGERO J, HOLFORD T, WHITE A, WALTER S, OSTFELD A, SOUTHWICK W. Acute Prolapsed Lumbar Intervertebral Disc An Epidemiologic Study with Special Reference to Driving Automobiles and Cigarette Smoking. Spine 1984, 9: 608-613. PMID: 6495031, DOI: 10.1097/00007632-198409000-00012.Peer-Reviewed Original ResearchConceptsCigarette smokingAverage riskNumber of pregnanciesPossible etiologic significanceCase-control studyEpidemiologic case-control studyRatio of menLumbar intervertebral discsNonoccupational factorsFemale ratioRisk factorsEpidemiologic studiesHigh riskSurgical casesEtiologic significanceNumber of childrenLumbar discIntervertebral discHigh heelsSmokingRiskNumber of hoursPast yearPregnancySurgeryAn epidemiological study of acute prolapsed cervical intervertebral disc.
Kelsey J, Githens P, Walter S, Southwick W, Weil U, Holford T, Ostfeld A, Calogero J, O'Connor T, White A. An epidemiological study of acute prolapsed cervical intervertebral disc. Journal Of Bone And Joint Surgery 1984, 66: 907-14. PMID: 6736091, DOI: 10.2106/00004623-198466060-00011.Peer-Reviewed Original ResearchConceptsCervical intervertebral discsCervical discEpidemiological studiesOnset of symptomsNumber of pregnanciesIntervertebral discBorderline statistical significanceSmoking cigarsLive birthsFrequent liftingFourth decadeAge groupsStatistical significanceHigh heelsCertain sportsPositive associationFrequent divingPregnancySymptomsNeckDiagnosisWomenAn epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc
Kelsey J, Githens P, White A, Holford T, Walter S, O'Connor T, Ostfeld A, Weil U, Southwick W, Calogero J. An epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc. Journal Of Orthopaedic Research® 1984, 2: 61-66. PMID: 6491800, DOI: 10.1002/jor.1100020110.Peer-Reviewed Original Research