2002
Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaire
2000
A Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence
Avants S, Margolin A, Holford T, Kosten T. A Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence. JAMA Internal Medicine 2000, 160: 2305-2312. PMID: 10927727, DOI: 10.1001/archinte.160.15.2305.Peer-Reviewed Original ResearchConceptsAuricular acupunctureCocaine dependenceCocaine addictionOpiate dependent populationUrine toxicology screenMethadone-maintained patientsCocaine-negative urine samplesDrug treatment facilitiesPrimary outcomeControlled TrialsToxicology screenTreatment modalitiesTreat sampleEffective treatmentUrine dataAcupunctureTreatment sessionsCocaine useRelaxation controlUrine samplesPatientsLongitudinal analysisTreatmentFurther investigationControl condition
1996
Time trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Flannery J, Liu W, Russi M, Boyle P. Time trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 67: 504-509. PMID: 8759608, DOI: 10.1002/(sici)1097-0215(19960807)67:4<504::aid-ijc7>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsThyroid cancerChildhood conditionsOverall age-adjusted incidence rateStrong birth cohort effectAge-adjusted incidence ratesRadiation treatmentBirth cohort effectsBirth cohort analysisTime trendsCohort effectsObserved time trendsIncidence ratePapillary carcinomaCohort analysisCancerCohortIncidenceNeckMalesFemalesUnited StatesRecent studiesTreatmentCurrent studyCarcinoma
1991
Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study
Peduzzi P, Detre K, Wittes J, Holford T. Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study. Journal Of Thoracic And Cardiovascular Surgery 1991, 101: 481-487. PMID: 1999942, DOI: 10.1016/s0022-5223(19)36731-5.Peer-Reviewed Original ResearchConceptsTreat analysisTreatment changesVeterans Administration Cooperative StudyDate of randomizationIschemic heart diseaseRandomized clinical trialsNew treatment groupEffect of treatmentStable anginaSurgical therapyMedical therapySurgical treatmentInitial treatmentSurgical interventionSurgery StudyMajor trialsHeart diseaseClinical trialsTreatment groupsCooperative StudySurvival dataTreatmentTherapyTrialsAdherence
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose