1997
Are cancers of the salivary gland increasing? Experience from Connecticut, USA.
Zheng T, Holford T, Chen Y, Ward B, Liu W, Flannery J, Boyle P. Are cancers of the salivary gland increasing? Experience from Connecticut, USA. International Journal Of Epidemiology 1997, 26: 264-271. PMID: 9169160, DOI: 10.1093/ije/26.2.264.Peer-Reviewed Original ResearchConceptsSalivary glandsRelative riskBirth cohortRare squamous cell carcinomaEpstein-Barr virus infectionConnecticut Tumor Registry dataTime trendsComparable relative riskSquamous cell carcinomaTumor registry dataAge group 40Salivary gland cancerYears of ageOlder age groupsRecent birth cohortsObserved time trendsPrior cancerLower gumCell carcinomaGland cancerIncidence rateRisk factorsUnivariate analysisCancer sitesRegistry dataTime trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A.
Zheng T, Holford T, Chen Y, Jones B, Flannery J, Boyle P. Time trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A. European Journal Of Cancer 1997, 33: 96-100. PMID: 9071907, DOI: 10.1016/s0959-8049(96)00371-1.Peer-Reviewed Original ResearchConceptsAge-adjusted incidence ratesSitu breast cancerFemale breast carcinomaIncidence rateBreast cancerMammography screeningBreast carcinomaOverall age-adjusted incidence rateAge group 40 yearsAge groupsEarly-stage breast cancerAge-specific incidence ratesFemale breast cancer incidenceConnecticut Tumor RegistryBreast cancer incidenceStage breast cancerEfficacy of mammographyFemale breast cancerAge group 40Older age groupsTime trendsTumor RegistryIncident casesDuctal carcinomaCancer incidence
1996
Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Mayne S, Liu W, Flannery J, Boyle P. Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 68: 172-176. PMID: 8900423, DOI: 10.1002/(sici)1097-0215(19961009)68:2<172::aid-ijc5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsUrinary bladder cancerMajor risk factorBladder cancerRisk factorsIncidence rateBirth-cohort patternSmoking-related cancersAnalytical epidemiologic studiesTime trendsTobacco smokingCigarette smokingLung cancerOccupational exposureEpidemiologic studiesCancerMarked increaseSmokingCohort effectsMalesRecent studiesCurrent studyFemalesIncidenceStudyConnecticutTime trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Flannery J, Liu W, Russi M, Boyle P. Time trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 67: 504-509. PMID: 8759608, DOI: 10.1002/(sici)1097-0215(19960807)67:4<504::aid-ijc7>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsThyroid cancerChildhood conditionsOverall age-adjusted incidence rateStrong birth cohort effectAge-adjusted incidence ratesRadiation treatmentBirth cohort effectsBirth cohort analysisTime trendsCohort effectsObserved time trendsIncidence ratePapillary carcinomaCohort analysisCancerCohortIncidenceNeckMalesFemalesUnited StatesRecent studiesTreatmentCurrent studyCarcinomaThe Continuing Increase in Adenocarcinoma of the Uterine Cervix: A Birth Cohort Phenomenon
ZHENG T, HOLFORD T, MA Z, CHEN Y, LIU W, WARD B, BOYLE P. The Continuing Increase in Adenocarcinoma of the Uterine Cervix: A Birth Cohort Phenomenon. International Journal Of Epidemiology 1996, 25: 252-258. PMID: 9119549, DOI: 10.1093/ije/25.2.252.Peer-Reviewed Original ResearchConceptsUterine cervixInvasive adenocarcinomaBirth cohortStrong birth cohort effectTime trendsBirth-cohort patternEnd Results (SEER) dataBirth-cohort phenomenonAnalytical epidemiological studiesBirth cohort effectsRecent birth cohortsObserved time trendsYoung white womenRisk factorsEpidemiological studiesCervixAdenocarcinomaCohort patternsCohort phenomenonCohortWhite womenCohort modelCohort effectsObserved increaseResult data
1995
Time trend in pancreatic cancer incidence in connecticut, 1935–1990
Zheng T, Holford T, Ward B, McKay L, Flannery J, Boyle P. Time trend in pancreatic cancer incidence in connecticut, 1935–1990. International Journal Of Cancer 1995, 61: 622-627. PMID: 7768634, DOI: 10.1002/ijc.2910610507.Peer-Reviewed Original ResearchConceptsOverall age-adjusted incidence rateAge-adjusted incidence ratesIncidence rateRecent birth cohortsPancreatic cancerBirth cohortIncident pancreatic cancer casesPancreatic cancer incidence ratesAge groupsAge-specific incidence ratesPancreatic cancer incidenceConnecticut Tumor RegistryBirth cohort trendsPancreatic cancer casesCancer incidence ratesTumor RegistryCancer incidenceCancer casesCohort modelingCohort trendsTime trendsCohortCancerIncidenceSex
1994
Time trend and the age‐period‐cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960‐1989
Zheng T, Holford T, Boyle P, Chen Y, Ward B, Flannery J, Mayne S. Time trend and the age‐period‐cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960‐1989. Cancer 1994, 74: 1556-1567. PMID: 8062189, DOI: 10.1002/1097-0142(19940901)74:5<1556::aid-cncr2820740511>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma, Bronchiolo-AlveolarAdultAge FactorsAgedAged, 80 and overCarcinomaCarcinoma, Small CellCarcinoma, Squamous CellCohort EffectCohort StudiesConnecticutFemaleHumansIncidenceLung NeoplasmsMaleMiddle AgedModels, StatisticalRegistriesSex FactorsSmokingTime FactorsConceptsAge-adjusted incidence ratesMajor histologic typesOverall age-adjusted incidence rateAge-specific incidence ratesHistologic typeLung cancer incidenceLung cancerIncidence rateBirth cohortRecent birth cohortsIncidence patternsObserved time trendsCell carcinomaCancer incidenceTime trendsConnecticut Tumor RegistryIncidence of adenocarcinomaSmall cell carcinomaSquamous cell carcinomaLung cancer casesRecent epidemiologic studiesDifferent histologic typesDifferent incidence patternsObserved incidence patternsTumor RegistryTime trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935‐1989
Katz D, Zheng T, Holford T, Flannery J. Time trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935‐1989. International Journal Of Cancer 1994, 58: 57-63. PMID: 8014016, DOI: 10.1002/ijc.2910580111.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaConnecticut Tumor RegistryCell carcinomaIncidence rateRenal cancerPopulation-based cancer registriesIncidence of adenocarcinomaTime trendsCohort effectsRegression modellingEffect of ageTumor RegistryCancer RegistryIncident casesUrinary tractRenal carcinomaBirth cohortCarcinomaAdenocarcinomaRate of riseIncidenceNegative cohort effectRegistryCancerMalesMalignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site
Chen Y, Zheng T, Holford T, Berwick M, Dubrow R. Malignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site. Cancer Causes & Control 1994, 5: 341-350. PMID: 8080946, DOI: 10.1007/bf01804985.Peer-Reviewed Original ResearchConceptsCutaneous malignant melanomaAnatomic sitesUpper limbPopulation-based Connecticut Tumor RegistryCohort patternsConnecticut Tumor RegistryMale-female ratioMalignant melanoma incidenceTime trendsCMM incidenceNeck melanomaTumor RegistryIncident casesMalignant melanomaMelanoma incidenceEtiologic distinctionsCarcinogenic exposuresLower limbsLargest absolute increaseMelanomaCohort modelingAbsolute increaseIncidenceLimbLargest relative increaseEstimating age, period and cohort effects using the multistage model for cancer
Holford T, Zhang Z, McKay L. Estimating age, period and cohort effects using the multistage model for cancer. Statistics In Medicine 1994, 13: 23-41. PMID: 9061838, DOI: 10.1002/sim.4780130105.Peer-Reviewed Original Research
1993
The time trend and age—period—cohort effects on incidence of adenocarcinoma of the stomach in connecticut from 1955–1989
Zheng T, Mayne S, Holford T, Boyle P, Liu W, Chen Y, Mador M, Flannery J. The time trend and age—period—cohort effects on incidence of adenocarcinoma of the stomach in connecticut from 1955–1989. Cancer 1993, 72: 330-340. PMID: 8319166, DOI: 10.1002/1097-0142(19930715)72:2<330::aid-cncr2820720205>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsDistal stomachGastric cardiaObserved time trendsRisk factorsIncidence rateBirth cohortAge-adjusted incidence ratesTime trendsDifferent epidemiologic featuresFuture analytic studiesIncrease of adenocarcinomaConnecticut Tumor RegistryIncidence of adenocarcinomaRisk of adenocarcinomaBirth-cohort phenomenonRegression modelingUnited States populationUnspecified subsiteRetinol intakeHiatal herniaTumor RegistryEpidemiologic featuresAlcohol intakeIncident casesEtiologic factors
1992
Time trends of non-Hodgkin's lymphoma: are they real? What do they mean?
Holford T, Zheng T, Mayne S, McKay L. Time trends of non-Hodgkin's lymphoma: are they real? What do they mean? Cancer Research 1992, 52: 5443s-5446s. PMID: 1394151.Peer-Reviewed Original ResearchTime trend and age-period-cohort effects on incidence of esophageal cancer in Connecticut, 1935–89
Zheng T, Mayne S, Holford T, Boyle P, Liu W, Chen Y, Mador M, Flannery J. Time trend and age-period-cohort effects on incidence of esophageal cancer in Connecticut, 1935–89. Cancer Causes & Control 1992, 3: 481-492. PMID: 1525329, DOI: 10.1007/bf00051361.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaIncidence rateCell carcinomaEsophageal cancerBirth cohortOverall age-adjusted incidence rateAge-adjusted incidence ratesConnecticut Tumor RegistryEsophageal cancer casesTime trendsEsophageal cancer ratesObserved time trendsGastric cardiaHistologic typeTumor RegistryIncident casesCancer ratesCancer casesAdenocarcinomaIncidence patternsEsophagusCancerLower thirdRegression modelingWhite males
1991
Trends in female breast cancer in Connecticut and the United States
Holford T, Roush G, McKay L. Trends in female breast cancer in Connecticut and the United States. Journal Of Clinical Epidemiology 1991, 44: 29-39. PMID: 1986055, DOI: 10.1016/0895-4356(91)90198-i.Peer-Reviewed Original ResearchConceptsBreast cancer mortalityBirth-cohort patternFemale breast cancerBreast cancerCancer mortalityCohort patternsPostmenopausal breast cancerInvasive breast cancerBlind biopsyBirth cohortMortalityCancerCohort modelingEarly detectionPrior reportsImproved treatmentTime trendsCohortU.S. mortalityModest declineLittle evidenceImportant differencesBiopsyIncidenceUnderdetection