2020
Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: a population-based case-control study in Connecticut and Massachusetts
Cheng Z, Zhang X, Bassig B, Hauser R, Holford T, Zheng E, Shi D, Zhu Y, Schwartz S, Chen C, Shi K, Qian Z, Boyle P, Zheng T. Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: a population-based case-control study in Connecticut and Massachusetts. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.o-os-525.Peer-Reviewed Original Research
2003
Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women
Morton L, Holford T, Leaderer B, Boyle P, Zahm S, Zhang Y, Flynn S, Tallini G, Zhang B, Owens P, Zheng T. Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women. British Journal Of Cancer 2003, 89: 2087-2092. PMID: 14647142, PMCID: PMC2376853, DOI: 10.1038/sj.bjc.6601388.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaCumulative lifetime exposureCurrent smoking statusCigarette smokingNHL subtypesFollicular lymphomaLifetime exposurePopulation-based case-control studyRisk of NHLEtiology of NHLNon-Hodgkin lymphoma subtypesDuration of smokingIntensity of smokingPrevious epidemiologic studiesCase-control studyPopulation-based controlsHistologic typeSmoking statusIncident casesTumor gradeLymphoma subtypesEpidemiologic studiesSmokingImmunologic typeLymphomaGlutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchRadiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaireA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original Research
2001
Lactation and breast cancer risk: a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Zhang Y, Zhang B, Boyle P, Zahm S. Lactation and breast cancer risk: a case–control study in Connecticut. British Journal Of Cancer 2001, 84: 1472-1476. PMID: 11384096, PMCID: PMC2363665, DOI: 10.1054/bjoc.2001.1793.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskIncident breast cancer casesMajor risk factorCase-control studyBreast cancer casesRisk reductionMenopausal statusParous womenPostmenopausal womenInverse associationRisk factorsCancer casesStudy interviewersFurther stratificationFirst childWomenStructured questionnaireLifetime durationCancerRiskLactationChildrenBreastfeeding
2000
Food group intake and the risk of oral epithelial dysplasia in a United States population
Morse D, Pendrys D, Katz R, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes & Control 2000, 11: 713-720. PMID: 11065008, DOI: 10.1023/a:1008943904085.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaFood group intakesGroup intakesEpithelial dysplasiaOdds ratio point estimateDairy food intakeFood frequency questionnaireOral Pathology LaboratoryCase-control studyRole of dietBread/cerealsConsumption of fruitsAspects of dietUnited States populationIncident casesOral cancerOral carcinogenesisHistopathologic diagnosisLate effectsFood intakeAppointment datePotential covariatesLogistic regressionTelephone interviewsPathology laboratoryBreast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls
Zheng T, Holford TR, Tessari J, Mayne ST, Owens PH, Ward B, Carter D, Boyle P, Dubrow R, Archibeque-Engle S, Zahm SH. Breast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls. American Journal Of Epidemiology 2000, 152: 50-58. PMID: 10901329, DOI: 10.1093/aje/152.1.50.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskCovariate-adjusted odds ratioBreast Cancer Risk AssociatedCase-control studyBreast cancer casesBreast adipose tissueMean tissue levelsCancer Risk AssociatedLowest tertileThird tertileBreast diseaseOdds ratioBreast cancerCancer casesConnecticut womenAdipose tissueFurther stratificationSignificant associationStudy participantsTissue levelsNonhormonal activitiesBody levelEnvironmental exposuresSpecific PCB congenersExposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk
Zheng T, Holford T, Mayne S, Owens P, Zhang B, Boyle P, Carter D, Ward B, Zhang Y, Zahm S. Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk. American Journal Of Epidemiology 2000, 151: 1103-1111. PMID: 10873135, DOI: 10.1093/oxfordjournals.aje.a010154.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskOdds ratioAge frequency-matched controlsIncident breast cancer patientsElectric blanketFrequency-matched controlsAdjusted odds ratioBreast cancer patientsEstrogen receptor statusFemale breast cancerCase-control studyDuration of useReceptor statusCancer patientsNever usersBreast cancerStudy interviewersRegular useLifetime useRiskStructured questionnaireExposureTotal
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levels
1997
Mouthwash use and dentures in relation to oral epithelial dysplasia
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Mouthwash use and dentures in relation to oral epithelial dysplasia. Oral Oncology 1997, 33: 338-343. PMID: 9415333, DOI: 10.1016/s1368-8375(97)00019-5.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaMouthwash useEpithelial dysplasiaDenture useOdds ratioYears of dentureOral Pathology LaboratoryCase-control studyConditional logistic regressionCase-control pairsOED casesAppointment datePotential associationLogistic regressionTelephone interviewsExposure informationPathology laboratoryConfidence intervalsDysplasiaDenturesMouthwashRiskSmokingYearsSurgeonsRisk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study
Zheng T, Holford T, Chen Y, Jiang P, Zhang B, Boyle P. Risk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study. Oral Oncology 1997, 33: 82-85. PMID: 9231164, DOI: 10.1016/s0964-1955(96)00056-5.Peer-Reviewed Original ResearchConceptsTongue cancerCase-control studyTobacco smokingAlcohol drinkingRisk factorsCurrent smokersCigarette equivalentsQuitting smokingEffect modificationTobacco consumptionSmokingAlcohol consumptionNumber of casesSignificant associationCancerYoung populationRiskRecent studiesDrinkingDaysSmokersYearsStudyDiseaseWeeks
1996
Smoking and drinking in relation to oral epithelial dysplasia.
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Mayne S. Smoking and drinking in relation to oral epithelial dysplasia. Cancer Epidemiology Biomarkers & Prevention 1996, 5: 769-77. PMID: 8896887.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaOdds ratioMouthwash useDenture statusRisk factorsEpithelial dysplasiaDrinks/weekAdjusted odds ratioImportant risk factorOral Pathology LaboratoryStandardized telephone interviewCase-control studyPotential risk factorsConditional logistic regressionLevel of smokingCurrent smokingAlcohol intakeIncident casesSmoking cessationOral cancerExcess riskHistopathological diagnosisSmokingAppointment dateLogistic regressionMalignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis
Chen Y, Dubrow R, Holford T, Zheng T, Barnhill R, Fine J, Berwick M. Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis. International Journal Of Cancer 1996, 67: 636-643. PMID: 8782651, DOI: 10.1002/(sici)1097-0215(19960904)67:5<636::aid-ijc8>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsMelanoma risk factorsCase-control studyRisk factorsAnatomic sitesSun exposurePopulation-based case-control studySun exposure-related factorsIntermittent sun exposureHistory of sunburnOnly risk factorPolychotomous logistic regression analysisInvasive melanoma casesNumber of neviLogistic regression analysisExposure-related factorsDevelopment of melanomaSex differencesPolychotomous logistic regressionHistologic subtypeMalignant melanomaClothing habitsPigmentary characteristicsMelanoma casesStudy subjectsLogistic regression
1992
The Genetic Epidemiology of Second Primary Breast Cancer*
Bernstein J, Thompson W, Risch N, Holford T. The Genetic Epidemiology of Second Primary Breast Cancer*. American Journal Of Epidemiology 1992, 136: 937-948. PMID: 1456270, DOI: 10.1093/oxfordjournals.aje.a116566.Peer-Reviewed Original ResearchConceptsSecond primary breast cancerPrimary breast cancerContralateral breast cancerFirst primary breast cancerFirst-degree relativesBreast cancerFamily historyOvarian cancerMulti-center population-based case-control studyPopulation-based case-control studyAge-adjusted rate ratioSteroid Hormone StudyBilateral breast cancerEnd Results ProgramRate ratioCase-control studyCorresponding rate ratiosContralateral breastEndometrial cancerProspective studyResults ProgramSecond primaryCohort membersHigh riskHormone Study
1985
Risk Factors for Fibrocystic Breast Disease and Its Histopathologic Components2
Berkowitz G, Kelsey J, LiVolsi V, Holford T, Merino M, Ort S, O'Connor T, White C. Risk Factors for Fibrocystic Breast Disease and Its Histopathologic Components2. Journal Of The National Cancer Institute 1985, 75: 43-50. PMID: 3859695, DOI: 10.1093/jnci/75.1.43.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseBenign breast diseaseBreast diseaseHigher socioeconomic statusOdds ratioLow Quetelet's indexSocioeconomic statusBreast cancer patientsCase-control studyEpidemiologic similaritiesCurrent smokersPostmenopausal womenPremenopausal womenEpithelial atypiaGross cystsFibrocystic diseaseCancer patientsPapillary hyperplasiaQuetelet indexBiopsy specimensRisk factorsSurgical conditionsConnecticut hospitalsLow parityBreast cancerAN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA
PASTIDES H, KELSEY J, HOLFORD T, LIVOLSI V. AN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA. American Journal Of Epidemiology 1985, 121: 440-447. PMID: 4014134, DOI: 10.1093/oxfordjournals.aje.a114016.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseDuctal epithelial atypiaCase-control studyBreast diseaseDuctal atypiaEpithelial atypiaMinimal atypiaBreast cancerFirst-degree female relativesBreast biopsy specimensRecent checkupSurgical menopauseEpidemiologic characteristicsFirst pregnancyBiopsy specimensRisk factorsEpidemiologic studiesAtypiaCheckupAtypia scoreFrequent checkupsBreast lesionsDiseaseFemale relativesOnly variableESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1
BERKOWITZ G, KELSEY J, HOLFORD T, LIVOLSI V, MERINO M, BECK G, ORT S, O'CONNOR T, WHITE C. ESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1. American Journal Of Epidemiology 1985, 121: 238-245. PMID: 4014118, DOI: 10.1093/oxfordjournals.aje.a113994.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseReplacement therapyPostmenopausal womenHospital-based case-control studyMedical care utilizationPossible risk factorsCase-control studyDuration of useOdds of diseasePostmenopausal women1Care utilizationMenopausal estrogensExcess oddsRisk factorsSurgical conditionsTherapyDiseasePositive associationMore yearsWomenOddsAssociationEstrogen
1984
Exogenous hormone use and fibrocystic breast disease by histopathologic component
Berkowitz G, Kelsey J, Livolsi V, Merino M, Holford T, Hildreth N, Ort S, O'Connor T, White C. Exogenous hormone use and fibrocystic breast disease by histopathologic component. International Journal Of Cancer 1984, 34: 443-449. PMID: 6490201, DOI: 10.1002/ijc.2910340403.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseGross cystsReplacement therapyHospital-based case-control studyExogenous hormone useOral contraceptive usePost-menopausal womenCase-control studyPostmenopausal womenPremenopausal womenHormone useOral contraceptivesEpithelial atypiaControl womenPapillary hyperplasiaBiopsy specimensFibrocystic lesionsSurgical conditionsContraceptive useHistopathologic componentsWomenIncreased occurrenceDisease