2022
vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding
Tran VN, Shams A, Ascioglu S, Martinecz A, Liang J, Clarelli F, Mostowy R, Cohen T, Abel zur Wiesch P. vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding. BMC Bioinformatics 2022, 23: 22. PMID: 34991453, PMCID: PMC8734216, DOI: 10.1186/s12859-021-04536-3.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacteriaComputer SimulationDrug Resistance, BacterialModels, BiologicalConceptsOwn computational model
2015
Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens
Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch M. Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens. Microbiology And Molecular Biology Reviews 2015, 79: 101-116. PMID: 25652543, PMCID: PMC4402963, DOI: 10.1128/mmbr.00039-14.Peer-Reviewed Original ResearchConceptsMDR infectionsPublic health threatMultiple drug resistanceHigh prevalenceMore effective interventionsDifferent underlying mechanismsMultidrug resistanceEffective interventionsHealth threatUnderlying mechanismInfectionBacterial pathogensMDRCommon mechanismDifferent pathogensProliferationPathogensPrevalenceHypothetical mechanismHow competition governs whether moderate or aggressive treatment minimizes antibiotic resistance
Colijn C, Cohen T. How competition governs whether moderate or aggressive treatment minimizes antibiotic resistance. ELife 2015, 4: e10559. PMID: 26393685, PMCID: PMC4641510, DOI: 10.7554/elife.10559.Peer-Reviewed Original Research
2009
What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch M. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? Journal Of The Royal Society Interface 2009, 7: 905-919. PMID: 19940002, PMCID: PMC2871802, DOI: 10.1098/rsif.2009.0400.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsStreptococcus pneumoniaeInfectious diseasesDrug-susceptible strainsHigher reproduction numberCent prevalenceSubstantial prevalencePersistent coexistenceDrug resistanceMultiple infectionsAntimicrobial useResistant strainsBacterial spreadAntimicrobial resistancePrevalenceDiseasePneumoniaeOutcomesReproduction numberTreatmentHost interactionsPathogensCoinfection