2000
Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2
Yang Z, Kyriakides T, Bornstein P. Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2. Molecular Biology Of The Cell 2000, 11: 3353-3364. PMID: 11029041, PMCID: PMC14997, DOI: 10.1091/mbc.11.10.3353.Peer-Reviewed Original ResearchConceptsCell-matrix interactionsAbnormal cell-matrix interactionsWild-type cellsTSP2-null miceAdhesive defectsComplex phenotypesCell spreadingMolecular mechanismsMutant fibroblastsProtein resultsMatrix proteinsStable transfectionMatrix metalloproteinasesMetalloproteinase-2Matricellular proteinAltered expressionTHBS2 geneNull miceAffinity chromatographyGelatinolytic assaysThrombospondin-2TSP2Matrix metalloproteinase-2FibroblastsLevels of MMP2
1999
Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene
Kyriakides T, Tam J, Bornstein P. Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene. Journal Of Investigative Dermatology 1999, 113: 782-787. PMID: 10571734, DOI: 10.1046/j.1523-1747.1999.00755.x.Peer-Reviewed Original ResearchConceptsGranulation tissueThrombospondin-2Late woundsControl woundsWound healingExtent of angiogenesisRe-epithelization rateAbnormal collagen fibrilsVascular densityLess scarringRete pegsHistologic analysisExcisional woundsControl epitheliumSuch woundsThrombospondin 2 geneTotal cellular contentAccelerated wound healingElevated levelsHealing processMiceWoundsBiopsy punchEarly woundsHealing