2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeStiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay
2023
Acute hospital use in older adults following the 2015 Dutch reform of long-term care: an interrupted time series analysis
Wammes J, Bakx P, Wouterse B, Buurman B, Murphy T, Vroomen J. Acute hospital use in older adults following the 2015 Dutch reform of long-term care: an interrupted time series analysis. The Lancet Healthy Longevity 2023, 4: e257-e264. PMID: 37269863, PMCID: PMC10316520, DOI: 10.1016/s2666-7568(23)00064-8.Peer-Reviewed Original ResearchConceptsIncident rate ratiosInterrupted time series analysisHospital dataOlder adultsAcute hospitalisationAcute hospital useAverage hospital lengthNational hospital dataMonthly rateLong-term careSupplementary Materials sectionAdvancing Translational SciencesHospital lengthHospital admissionAverage LOSLTC reformHospitalisationCurative careHospital useLongitudinal increaseRate ratioMedical specialistsNational InstituteAdultsLOSPerformance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useDistressing symptoms after major surgery among community‐living older persons
Gill T, Han L, Murphy T, Feder S, Gahbauer E, Leo‐Summers L, Becher R. Distressing symptoms after major surgery among community‐living older persons. Journal Of The American Geriatrics Society 2023, 71: 2430-2440. PMID: 37010784, PMCID: PMC10524276, DOI: 10.1111/jgs.18357.Peer-Reviewed Original ResearchConceptsCommunity-living older personsMajor surgeryDistressing symptomsArea Deprivation IndexOlder personsSocioeconomic disadvantageCommunity-living personsTiming of surgeryProspective longitudinal studyYears of ageQuality of lifeSymptom burdenNonelective surgeryPresurgery valuesElective surgeryMultivariable analysisFunctional outcomeNonelective proceduresChronic conditionsSurgerySymptomsProportional increaseMedicaid eligibilityDeprivation indexMonthsA multivariate joint model to adjust for random measurement error while handling skewness and correlation in dietary data in an epidemiologic study of mortality
Agogo G, Muchene L, Orindi B, Murphy T, Mwambi H, Allore H. A multivariate joint model to adjust for random measurement error while handling skewness and correlation in dietary data in an epidemiologic study of mortality. Annals Of Epidemiology 2023, 82: 8-15. PMID: 36972757, PMCID: PMC10239394, DOI: 10.1016/j.annepidem.2023.03.007.Peer-Reviewed Original ResearchConceptsCause mortalityDietary intakeNational Death Index mortality dataIntake levelsDietary fiber intakeNutrition Examination SurveyUS National HealthHazard ratioMultivariate joint modelExamination SurveyPerson intakeNational HealthUnhealthy dietFiber intakeEpidemiologic studiesDietary dataRelative hazardGlobal deathsMortality dataIntakeMortalitySubstantial proportionDeathDietary fiberLongitudinal measuresAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codesAssociation of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction
Okafor C, Zhu C, Raparelli V, Murphy T, Arakaki A, D’Onofrio G, Tsang S, Smith M, Lichtman J, Spertus J, Pilote L, Dreyer R. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction. JAMA Network Open 2023, 6: e2255843. PMID: 36787140, PMCID: PMC9929697, DOI: 10.1001/jamanetworkopen.2022.55843.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung adultsHospital readmissionBlack raceMyocardial infarctionRacial differencesCardiac factorsSociodemographic characteristicsBlack individualsOdds of readmissionObservational cohort studyMedical record abstractionRisk of readmissionWhite individualsAdults Aged 18Year of dischargePostdischarge readmissionVIRGO StudyCause readmissionCohort studyPrimary outcomeRecord abstractionMulticenter studyAged 18Male ratio
2022
A risk model for decline in health status after acute myocardial infarction among older adults
Hajduk A, Dodson J, Murphy T, Chaudhry S. A risk model for decline in health status after acute myocardial infarction among older adults. Journal Of The American Geriatrics Society 2022, 71: 1228-1235. PMID: 36519774, PMCID: PMC10089939, DOI: 10.1111/jgs.18162.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status declineImportant patient-centered outcomesPatient-centered outcomesMyocardial infarctionStatus declineHealth statusOlder adultsShort Form-12 Physical Component ScorePhysical component scoreProspective cohort studyRisk prediction modelLogistic regression modelsOlder adult survivorsPredictive risk modelRisk modelCohort studyPatient ageValidation cohortC-statisticRisk factorsHigh riskLower riskAdult survivorsHospitalization
2011
Bayesian Time-Series Analysis of a Repeated-Measures Poisson Outcome With Excess Zeroes
Murphy TE, Van Ness PH, Araujo KL, Pisani MA. Bayesian Time-Series Analysis of a Repeated-Measures Poisson Outcome With Excess Zeroes. American Journal Of Epidemiology 2011, 174: 1230-1237. PMID: 22025357, PMCID: PMC3254157, DOI: 10.1093/aje/kwr252.Peer-Reviewed Original ResearchConceptsPosterior predictive simulationsExcess zerosBayesian modelBayesian time series analysisPredictive simulationsHierarchical Bayesian modelPoisson outcomesPosterior distributionTime series analysisBayesian frameworkRelated resultsStatistical factorsBayesian analysisRandom effects Poisson modelFrequentistZerosPoisson modelSmall samplesExcessive numberAutocorrelationSimulationsTime series techniquesModelPeriodicityBayesian hierarchical modeling for a non‐randomized, longitudinal fall prevention trial with spatially correlated observations
Murphy TE, Allore HG, Leo‐Summers L, Carlin BP. Bayesian hierarchical modeling for a non‐randomized, longitudinal fall prevention trial with spatially correlated observations. Statistics In Medicine 2011, 30: 522-530. PMID: 21294148, PMCID: PMC3477673, DOI: 10.1002/sim.3912.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAgedAged, 80 and overAlgorithmsBayes TheoremComputer SimulationConnecticutControlled Clinical Trials as TopicEmergency Medical ServicesFemaleHumansLongitudinal StudiesMaleMarkov ChainsModels, StatisticalMonte Carlo MethodPatient Education as TopicPoisson DistributionTreatment OutcomeConceptsNon-randomized designFall prevention trialsPersons 70 yearsCommunity-based health interventionsNon-randomized interventionsRandomization of participantsInjurious fallsPrevention trialsEmergency departmentFall preventionInterventional effectsLongitudinal trialCare areasConnecticut CollaborationHealth interventionsInterventional designHealthcare interventionsMedicaid ServicesOlder adultsIntervention areaSerious injuriesZip codesTrialsInterventionInfluential covariates
2010
Treatment of Death in the Analysis of Longitudinal Studies of Gerontological Outcomes
Murphy TE, Han L, Allore HG, Peduzzi PN, Gill TM, Lin H. Treatment of Death in the Analysis of Longitudinal Studies of Gerontological Outcomes. The Journals Of Gerontology Series A 2010, 66A: 109-114. PMID: 21030467, PMCID: PMC3011957, DOI: 10.1093/gerona/glq188.Peer-Reviewed Original ResearchConceptsFunctional disabilityOlder study populationStudy populationLongitudinal studyOlder personsCommunity-living older personsHealthy survivor effectLongitudinal outcomesSurvivor effectFunctional abilityDeathOutcomesDisabilityLongitudinal modelingTreatmentInformative censoringNoninformative censoringRapid declineStrong relationshipCohortPopulationPersonsStudySurvivorsDecedents
2008
Assessing Multiple Medication Use With Probabilities of Benefits and Harms
Murphy TE, Agostini JV, Van Ness PH, Peduzzi P, Tinetti ME, Allore HG. Assessing Multiple Medication Use With Probabilities of Benefits and Harms. Journal Of Aging And Health 2008, 20: 694-709. PMID: 18625759, PMCID: PMC3477770, DOI: 10.1177/0898264308321006.Peer-Reviewed Original ResearchEffect of Dissemination of Evidence in Reducing Injuries from Falls
Tinetti ME, Baker DI, King M, Gottschalk M, Murphy TE, Acampora D, Carlin BP, Leo-Summers L, Allore HG. Effect of Dissemination of Evidence in Reducing Injuries from Falls. New England Journal Of Medicine 2008, 359: 252-261. PMID: 18635430, PMCID: PMC3472807, DOI: 10.1056/nejmoa0801748.Peer-Reviewed Original ResearchConceptsFall-related injuriesSerious fall-related injuriesAdjusted ratesIntervention regionClinical practiceElderly personsPercentage of cliniciansPrimary care cliniciansPrevention of fallsMedical servicesRate of injuryYears of ageEvaluation periodDissemination of evidenceCare cliniciansIntervention visitsOutpatient rehabilitationPreintervention periodFall preventionMorbid conditionsNonrandomized designInjuryReducing InjuryCliniciansRegions of Connecticut
2007
Hierarchical models to evaluate translational research: Connecticut collaboration for fall prevention
Murphy TE, Tinetti ME, Allore HG. Hierarchical models to evaluate translational research: Connecticut collaboration for fall prevention. Contemporary Clinical Trials 2007, 29: 343-350. PMID: 18054289, PMCID: PMC2453244, DOI: 10.1016/j.cct.2007.10.004.Peer-Reviewed Original ResearchConceptsHealth care utilizationPre-intervention periodCare utilizationStudy armsFall preventionConnecticut CollaborationFall-related injuriesTranslational studiesHealth SourceOlder personsTranslational researchDemographic characteristicsTemporal trendsSignificant differencesInterventionPreventionPublic health sourcesQuasi-experimental designArmInjuryZCTAs