Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*. Journal Of Biological Chemistry 2012, 287: 44301-44319. PMID: 23129762, PMCID: PMC3531745, DOI: 10.1074/jbc.m112.413161.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid MotifsAmino Acid SequenceAmino Acid SubstitutionAnimalsBehaviorCase-Control StudiesDimerizationFemaleHumansMaleMiceMice, 129 StrainMice, KnockoutMiddle AgedMolecular Sequence DataProtein BindingReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaSchizophrenic PsychologySequence AlignmentYoung AdultConceptsFrontal cortexMetabotropic glutamate 2 receptorGPCR heteromersBehavioral functionsMouse frontal cortexPsychosis-like effectsHallucinogenic 5Receptor neurotransmissionSchizophrenic subjectsReceptor heteromerizationReceptor complex formationSerotoninCortexHeteromeric expressionReceptorsReceptor heterocomplexDomain fourHeteromeric complexesCell signalingThree residuesHeteromersIntracellular endNeurotransmissionAgonistsMice