HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience 2012, 15: 1245-1254. PMID: 22864611, PMCID: PMC3431440, DOI: 10.1038/nn.3181.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsAntipsychotic AgentsBenzamidesChromatin ImmunoprecipitationClozapineDNA MethylationGenetic VectorsHEK293 CellsHerpesvirus 2, HumanHistone Deacetylase 2HistonesHumansHydroxamic AcidsImmunohistochemistryMiceMice, KnockoutPatch-Clamp TechniquesPlasmidsPrefrontal CortexPromoter Regions, GeneticPyridinesReal-Time Polymerase Chain ReactionReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateReflex, StartleSchizophrenic PsychologyVorinostat